425 research outputs found
Requirements for contractility in disordered cytoskeletal bundles
Actomyosin contractility is essential for biological force generation, and is
well understood in highly organized structures such as striated muscle.
Additionally, actomyosin bundles devoid of this organization are known to
contract both in vivo and in vitro, which cannot be described by standard
muscle models. To narrow down the search for possible contraction mechanisms in
these systems, we investigate their microscopic symmetries. We show that
contractile behavior requires non-identical motors that generate large enough
forces to probe the nonlinear elastic behavior of F-actin. This suggests a role
for filament buckling in the contraction of these bundles, consistent with
recent experimental results on reconstituted actomyosin bundles.Comment: 10 pages, 6 figures; text shortene
Depairing critical current achieved in superconducting thin films with through-thickness arrays of artificial pinning centers
Large area arrays of through-thickness nanoscale pores have been milled into
superconducting Nb thin films via a process utilizing anodized aluminum oxide
thin film templates. These pores act as artificial flux pinning centers,
increasing the superconducting critical current, Jc, of the Nb films. By
optimizing the process conditions including anodization time, pore size and
milling time, Jc values approaching and in some cases matching the
Ginzburg-Landau depairing current of 30 MA/cm^2 at 5 K have been achieved - a
Jc enhancement over as-deposited films of more than 50 times. In the field
dependence of Jc, a matching field corresponding to the areal pore density has
also been clearly observed. The effect of back-filling the pores with magnetic
material has then been investigated. While back-filling with Co has been
successfully achieved, the effect of the magnetic material on Jc has been found
to be largely detrimental compared to voids, although a distinct influence of
the magnetic material in producing a hysteretic Jc versus applied field
behavior has been observed. This behavior has been tested for compatibility
with currently proposed models of magnetic pinning and found to be most closely
explained by a model describing the magnetic attraction between the flux
vortices and the magnetic inclusions.Comment: 9 pages, 10 figure
A cycling state that can lead to glassy dynamics in intracellular transport
Power-law dwell times have been observed for molecular motors in living
cells, but the origins of these trapped states are not known. We introduce a
minimal model of motors moving on a two-dimensional network of filaments, and
simulations of its dynamics exhibit statistics comparable to those observed
experimentally. Analysis of the model trajectories, as well as experimental
particle tracking data, reveals a state in which motors cycle unproductively at
junctions of three or more filaments. We formulate a master equation for these
junction dynamics and show that the time required to escape from this
vortex-like state can account for the power-law dwell times. We identify trends
in the dynamics with the motor valency for further experimental validation. We
demonstrate that these trends exist in individual trajectories of myosin II on
an actin network. We discuss how cells could regulate intracellular transport
and, in turn, biological function, by controlling their cytoskeletal network
structures locally
Folding of small proteins: A matter of geometry?
We review some of our recent results obtained within the scope of simple
lattice models and Monte Carlo simulations that illustrate the role of native
geometry in the folding kinetics of two state folders.Comment: To appear in Molecular Physic
Cochlear Implants in the Workplace: A Nationwide Survey
A nation wide survey of cochlear implant recipients was conducted to study how implants may impact people at work. Using a self-reporting questionnaire, recipients using four cochlear implant designs were surveyed about spoken communication on the job, overall job performance, job satisfaction, confidence in job retention and in seeking new employment, job promotion, and income. Of the implant recipients using their implants at work (106 people), the majority used their implants during all work hours and reported positive changes in their job situations. The survey results suggest that cochlear implants may help in mitigating functional limitations in the workplace resulting from profound hearing loss
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