32 research outputs found
The effect of PAI-1 Gene Variants on Development of Thrombophilia in Patients with Klinefelter Syndrome
FACTORS AFFECTING ADMINISTRATIVE AND ORGANIZATIONAL SUCCESS IN THE TURKEY'S FORESTRY
This study was dealt with aiming to examine the most important factors
(education and self-development, administrative competence, success
mentality, motivation and rewarding) affecting administrative and
organizational success in the forest resource management of Turkey. For
this purpose, four different questionnaires were applied to the total of
565 interviewees related to the forestry section of the Ministry of
Forestry and Water Affairs and four different interest groups
(employees, subject experts, related institutions and nongovernmental
organizations representatives) in nine geographical regions of Turkey.
To gather data about the subject and to reach the results, face to face
interviews were conducted with interest groups, a questionnaire was
applied. The layered-simple random sampling method was used as a
sampling method. All obtained data were used as material. The research
data were evaluated with descriptive statistics, it was inspected with
the Kruskal-Wallis H-Test whether the thoughts of the interviewees
related to the most important factors affecting administrative and
organizational success differ according to the regions, and the
departments, the position and the experience. The different groups were
determined by the Duncan Test. Accordingly, most of the interviewees
think that the undergraduate education, prevocational and in-service
training are inadequate and that they need the most social and economic
comprehensive information in the management of forest resources. Middle
and upper level managers have the opportunity to further develop
themselves, as the duration of experience increases, the administrative
competence about forest resources management increases, but scientific
studies and research results related to forestry are mostly not
followed. The majority of the interviewees correctly identified
administrative and organizational success in forestry, determined the
most important factors affecting success as organizational and
administrative factors and found that there was little or no
relationship between success and reward. To increase the success in the
forestry, the employees should participate in decisions and the success
should be measured and evaluated objectively and numerically in the form
of institutional success. According to the results, some suggestions
were put forward for development of forest resources management
DNA repair gene XPD Asp312Asn and XRCC4 G-1394T polymorphisms and the risk of autism spectrum disorder
Autism spectrum disorder (ASD) is a complex disorder, and its extreme heterogeneity further complicates our understanding of its biology. Epidemiological evidence from family and twin studies supports a strong genetic component in ASD etiology. Oxidative stress and abnormal DNA methylation have been implicated in the pathophysiology of ASD. Brain tissues from ASD cases showed higher levels of oxidative stress biomarkers than healthy controls in postmortem analysis. Association between oxidative stress and DNA damage has been well-known. Thus, we sought to investigate a potential link between DNA repair genes and ASD and analyze the role of XPD Asp312Asn and XRCC4 G-1394T gene polymorphisms for ASD in the Turkish population. Genotyping was conducted by PCR-RFLP based on 100 patients and 96 unrelated healthy controls. We, for the first time, demonstrated a positive association between XRCC4 gene variants and ASD risk. Frequencies of XRCC4-1394 T/G+G/G genotypes were higher in patients (%34) than the controls (%18.7). The statistical analysis revealed that the individuals who had XRCC4-1394 T/G+G/G genotype had an increased risk for ASD (OR = 2.23, 95% CI = 1.10-4.55). However, no significant association was found for XPD Asp312Asn polymorphism with the risk of ASD. Our findings suggest that XRCC4 G-1394T polymorphism might be associated with ASD pathogenesis
Common MEFV mutations and polymorphisms in an elderly population: an association with E148Q polymorphism and rheumatoid factor levels.
Candidate Gene Search For Autosomal Dominant Behcet's Disease Through Whole Exome Sequencing
Common MEFV mutations and polymorphisms in an elderly population: an association with E148Q polymorphism and rheumatoid factor levels
Objectives. To analyse the most common MEFV (Mediterranean fever gene) mutations and polymorphisms in an elderly population free of chronic inflammatory disease (n=764), and explore possible associations between hsCRP (high sensitive C-reactive protein) and RF (rheumatoid factor) levels with MEFV mutations and polymorphisms