Anesthetic management of laryngectomy and neck dissection surgery: Retrospective analysis [Larenjektomi ve boyun diseksiyonu operasyonlarinda anestezi yönetimi: Retrospektif analiz]

Objective: Laryngectomy and neck dissection are among the special operations in terms of anesthesia management as well as surgical application. In this retrospective study, it was aimed to evaluate the perioperative anesthesia management of the patients who underwent laryngectomy and/or neck dissection operation by the otolaryngology department and discuss. Method: A total of 44 patients between 2014 and 2017 were retrospectively evaluated. Results: The study was completed with 42 patients as all records of 2 could'nt obtained. Forty patients were male and 2 were female. Total laryngectomy+neck dissection was performed in 31 patients(73.8%), total laryngectomy+total thyroidectomy+neck dissection operation was performed in 11 patients (26.2%). Mean blood loss was 239±156 ml. No blood and blood products were transfused for 35 patients (83.3%). Four patients had 1 unit and 3 patients had 2 erythrocyte suspension units. The most common complication observed during the operation was deep hypotension with 23.8% (10 patients). Ephedrine and adrenaline were applied in the treatment of hypotension. Three patients required deep bradycardia for treatment and atropine was administered. Hypocalcemia developed in 12 patients, postoperatively. Conclusion: Laryngectomy and neck dissection operations are special operations in terms of surgery and anesthesia management and require close follow-up for possible peroperative and/or postoperative complications. © 2018 Anestezi Dergisi. All rights reserved

EVALUATION OF OXIDATIVE STRESS MARKERS AND ANTIOXIDANT STATUS IN THE ALZHEIMER DISEASE, VASCULAR DEMENTIA AND THE PARKINSON DISEASE

WOS: 000318748400022Oxidative stress may be involved in pathogenesis of neurodegenerative diseases. We aimed to measure MDA, NO, 8-OHdG and TAC, SOD and CAT levels in the Alzheimer disease, Parkinson disease and vascular dementia, and evaluate oxidant and antioxidant status in these diseases. Oxidative stress parameters were measured in 20 patients with vascular dementia, 20 patients with the Alzheimer disease, 20 patients with the Parkinson disease and 20 matching controls. MDA, NO and TAC were assayed with spectrophotometric methods. 8-OHdG was quantitated by the Elisa method. SOD and CAT were assayed with colorimetric methods. MDA, NO, 8-OHdG and SOD levels in total patient group were higher (p = 0.039, 0.041, 0.021 and 0.045, respectively), while TAC levels were lower (p = 0.010) as compared with controls. When compared to controls, the following were higher: MDA in the Parkinson disease (p = 0.036); NO in the Alzheimer disease (p = 0.028). However, TAC in the Alzheimer disease (p = 0.024) were lower. We observed negative correlations between TAC and MDA in the Parkinson disease (r = -0.496, p = 0.026); between SOD and 8-OHdG in the Alzheimer disease (r = 0.526, p = 0.017). These findings support the idea that the oxidative stress may play an important role in the pathogenesis of neurodegenerative diseases. This preliminary study shows an increase in free radical production in the Alzheimer disease and Parkinson disease. Also, there is a defect in the antioxidant defense system, which may lead to oxidative damage in patients with the Alzheimer disease

Evaluation of oxidative stress markers and antioxidant status in dementia and Parkinson disease

36th FEBS Congress of the Biochemistry for Tomorrows Medicine -- JUN 25-30, 2011 -- Torino, ITALYWOS: 000292333102456…Federat Soc Biochem & Mol Bio

Endoscopic versus microscopic stapes surgery

PubMedID: 27461175Objective The aim of this study to compare the outcomes and complications of endoscopic stapes surgery versus microscopic stapes surgery. Methods This study involved patients who underwent stapedotomy at the Department of Otorhinolaryngology, Faculty of Medicine, Cukurova University between January 2012 and July 2014. The patients were divided into two groups. Patients in group I were operated with endoscope and patients in group II were operated with microscope. Pure tone audiometry was carried out in all patients preoperatively. Peroperative surgical findings, complications, and duration of surgery were noted and compared between the two groups. Air conduction and bone conduction thresholds were measured at frequencies of 500, 1000, 2000, and 4000 Hz, and the mean (±SD) air-bone gap was noted. Results Mean preoperative air-bone gap was 36.9 ± 6.8 dB (23.3–50 dB) in group I and 35.1 ± 6 dB (26.6–50 dB) in group II. Mean postoperative air-bone gap was 9.3 ± 7.1 dB (0–30 dB) in group I and 13.5 ± 9.7 dB (1.6–35 dB) in group II. The difference in preoperative and postoperative air-bone gap between the two groups was statistically significant (p = 0.023). Patients in group I did not complain of postoperative pain but this was felt in four patients in group II. The difference was statistically significant (p = 0.045). Conclusion Endoscopic stapes surgery has many benefits such as good visualization, and easy accessibility to the stapes, oval window niche, and facial nerve. Removal of the scutum and manipulation of the chorda tympani nerve are less frequent with the endoscopic technique. © 2016 Elsevier Ireland Lt

How does cochlear implantation affect five vestibular end-organ functions and dizziness?

PubMedID: 30100248Objective: To evaluate all five vestibular end-organ functions (lateral, anterior, posterior semicircular canal, utricule, and saccule) and to investigate the relationship between Dizziness Handicap Inventory (DHI) and vestibular functions prior to CI (cochlear implantation) and at postoperative day 3 and month 3. Methods: A total of 42 patients (age 16–70 years) with normal vestibular functions preoperatively and undergoing unilateral CI were included in this prospective descriptive study. Video head impulse test (vHIT) for three semicircular canal (SSC) functions, ocular vestibular-evoked myogenic potential (oVEMP) for utricule function, cervical vestibular-evoked myogenic potential (cVEMP) for saccule function and DHI for subjective vertigo symptoms were performed prior to CI and at postoperative day 3 and month 3. Results: There was a significant impairment of vestibular function in 12 patients (28.5%) on the implantation side and significant DHI increase was observed in 13 of 42 (30.9%) patients at postoperative day 3 after CI (p 0.05). The deterioration in cVEMP continued in 5 (11.9%) patients (p 0.05). There was a significant correlation between DHI and objective vestibular tests both in the early and late postoperative period (r = 0.795; p < 0.05). Conclusion: Our study showed that both canal and otolith functions can be damaged after CI especially in the early postoperative period. Surprisingly, posterior SSC functions were more affected than lateral SSC. Therefore, a gold standard vestibular test battery that can evaluate each of three SSC canals and two otoliths functions is essential. Since a single vestibular test for this purpose is not available, we recommend the use of the three available vestibular tests together. This test battery, which is capable of evaluating five vestibular end-organ functions in preoperative and postoperative vestibular evaluations, can provide more accurate results not only for CI but also for most otologic surgeries. © 2018 Elsevier B.V.This study was not supported by any organization or foundation

Effects of agmatine sulphate on facial nerve injuries

PubMedID: 28122652Objective: To evaluate the effect of agmatine sulphate on facial nerve regeneration after facial nerve injury using electron and light microscopy. Methods: The study was performed on 30 male Wistar albino rats split into: a control group, a sham-treated group, a study control group, an anastomosis group, and an anastomosis plus agmatine sulphate treatment group. The mandibular branch of the facial nerve was dissected, and a piece was removed for histological and electron microscopic examination. Results: Regeneration was better in the anastomosis group than in the study control group. However, the best regeneration findings were seen in the agmatine sulphate treatment group. There was a significant difference between the agmatine group and the others in terms of median axon numbers (p < 0.004) and diameters (p < 0.004). Conclusion: Agmatine sulphate treatment with anastomosis in traumatic facial paralysis may enhance nerve regeneration. Copyright © JLO (1984) Limited 2017