Ionic behavior assessment of surface-active compounds from corn steep liquor by exchange resins

Depending on their ionic nature, biosurfactants can be classified as nonionic, anionic, cationic, or amphoteric. The ionic behavior of biosurfactants is an important characteristic that dictates their use in industrial applications. In this work, a biosurfactant extract obtained from corn steep liquor was subjected to anionic or cationic resins, in order to study the ionic behavior under different operational conditions using response surface methodology. The independent variables included in the study are the dilution of biosurfactant solution, the amount of cationic or anionic resin, and the extraction time, whereas the dependent variables studied consisted of the surface tension of biosurfactant aqueous solution, after contacting with anionic or cationic resin. The results showed that biosurfactant extracted from corn steep liquor is amphoteric, since both resins were able to entrap this biosurfactant, making it particularly suited for use in personal care preparations for sensitive skin.Peer ReviewedPostprint (author's final draft

Bozepinib: A Promising Selective Derivative Targeting Breast Cancer Stem Cells

Bozepinib is a potent antitumour compound that shows an IC50 of 0.166 μM against MDA-MB-231 human breast cancer cell line. It is also a very selective drug that presents a therapeutic index (TI) of 11.0 against MDA-MB-231 in relation to the normal MCF-10A. It is important to identify new cancer stem-like cells (CSCs) anticancer drugs to struggle against the resistance and the high risk of relapse in patients. In the present chapter, we show how bozepinib demonstrated selectivity on cancer cells and showed an inhibitory effect over kinases involved in carcinogenesis, proliferation and angiogenesis. Bozepinib inhibits HER-2 signaling pathway and JNK and ERK kinases. In addition, it has an inhibitory effect on AKT and VEGF together with anti-angiogenic and anti-migratory activities. Interestingly, bozepinib suppresses the formation of both mammo- and colonospheres and eliminated ALDH+ CSC subpopulations at a low micromolar range similar to salinomycin. It also induces the downregulation of SOX2, c-MYC and β-CATENIN and upregulation of the GLI-3 Hedgehog signaling repressor. Finally, bozepinib shows in vivo antitumor and anti-metastatic efficacy in xenotransplanted nude mice without presenting subacute toxicity. However, further studies in cancer patients are needed to confirm the therapeutic potential of bozepinib

The Brightest Cluster Galaxy in Abell 85: The Largest Core Known so far

We have found that the brightest cluster galaxy (BCG) in Abell~85, Holm 15A, displays the largest core so far known. Its cusp radius, $r_{\gamma} = 4.57 \pm 0.06$ kpc ($4.26^{\prime\prime}\pm 0.06^{\prime\prime}$), is more than 18 times larger than the mean for BCGs, and $\geq1$ kpc larger than A2261-BCG, hitherto the largest-cored BCG (Postman, Lauer, Donahue, et al. 2012) Holm 15A hosts the luminous amorphous radio source 0039-095B and has the optical signature of a LINER. Scaling laws indicate that this core could host a supermassive black hole (SMBH) of mass $M_{\bullet}\thicksim (10^{9}-10^{11})\,M_{\odot}$. We suggest that cores this large represent a relatively short phase in the evolution of BCGs, whereas the masses of their associated SBMH might be set by initial conditions.Comment: 14 pages, 3 figure, 2 tables, accepted for publication in ApJ Letters on October 6th, 2014, replacement of previous manuscript submitted on May 30th, 2014 to astro-p

El cuestionario CEVEAPEU. Un instrumento para la evaluación de las estrategias de aprendizaje de los estudiantes universitarios

El objetivo de este trabajo era elaborar y validar un cuestionario de evaluación de las estrategias de aprendizaje de los estudiantes universitarios más completo que los clásicamente utilizados. Para ello utilizamos un diseño de validación de pruebas. Usamos dos muestras de estudiantes universitarios, la primera de 545 estudiantes y la segunda de 1127. Los resultados de consistencia interna, validez de constructo, validez predictiva y estabilidad temporal, recogidos en el texto del artículo, son buenos. El producto final es un cuestionario con dos escalas, seis subescalas, veinticinco estrategias y 88 ítems, más sólido y completo que los anteriormente disponibles

Testing models with non-minimal Higgs sector through the decay t->q+WZ

We study the contribution of charged Higgs boson to the rare decay of the top quark t->q+WZ (q=d,s,b) in models with Higgs sector that includes doublets and triplets. Higgs doublets are needed to couple charged Higgs with quarks, whereas the Higgs triplets are required to generate the non-standard vertex HWZ at tree-level. It is found that within a model that respect the custodial SU(2) symmetry and avoids flavour changing neutral currents by imposing discrete symmetries, the decay mode t->b+WZ, can reach a branching ratio of order 0.0178, whereas the decay modes t->(d,s)+WZ, can reach a similar branching ratio in models where flavour changing neutral currents are suppressed by flavour symmetries.Comment: Typeset using REVTEX and EPSF, 5 pag, 2 figure

Dual encoding of muscle tension and eye position by abducens motoneurons

Extraocular muscle tension associated with spontaneous eye movements has a pulse-slide-step profile similar to that of motoneuron firing rate. Existing models only relate motoneuron firing to eye position, velocity and acceleration. We measured and quantitatively compared lateral rectus muscle force and eye position with the firing of abducens motoneurons in the cat to determine fundamental encoding correlations. During fixations (step), muscle force increased exponentially with eccentric eye position, consistent with a model of estimate ensemble motor innervation based on neuronal sensitivities and recruitment order. Moreover, firing rate in all motoneurons tested was better related to eye position than to muscle tension during fixations. In contrast, during the postsaccadic slide phase, the time constant of firing rate decay was closely related to that of muscle force decay, suggesting that all motoneurons encode muscle tension as well. Discharge characteristics of abducens motoneurons formed overlapping clusters of phasic and tonic motoneurons, thus, tonic units recruited earlier and had a larger slide signal. We conclude that the slide signal is a discharge characteristic of the motoneuron that controls muscle tension during the postsaccadic phase and that motoneurons are specialized for both tension and position-related properties. The organization of signal content in the pool of abducens motoneurons from the very phasic to the very tonic units is possibly a result of the differential trophic background received from distinct types of muscle fibers

Characterization of ionic nature of biosurfactant extracted from corn steep liquor using ionic exchange resins

[Excerpt] Resins have been used for years for the purification and characterization of ionic substances. The use of these resins allows not only remove impurities or increase the concentration of metabolites from industrial streams, but also allows define their ionic structure. In general, surfactants can be classified as non-ionic, anionic, cationic or amphoteric, what is going to define their future application at industrial scale. For example, anionic surfactants present the greatest wetting and emulsifying properties, while cationic ones have excellent antibacterial properties as well as good emulsifier capacities. Otherwise, amphoteric surfactants, which may have anionic or cationic properties depending on pH, are widely used in personal care products because of their less irritability to skin and eyes in comparison with other types of surfactants. [...]Spanish Ministry of Economy and Competitiveness (FEDER funds under the project CTM2015-68904)University of Vigo (Spain

Potential applications of biosurfactant extract obtained from corn steep liquor in hair formulations

[Excerpt] Biosurfactants (BS) have great advantages as an eco-friendly alternative to synthetic surfactants used in hair formulations. Human hair contains fatty acids (palmitic, palmitoleic, oleic and stearic acid) that prevent hair dryness and avoid the lower scalp hair density. These fatty acids are included in the composition of biosurfactant extract obtained from corn steep liquor (CSL) (Vecino et al., 2015). The adsorption of surfactants on hair depends on its ionic charge. Normally, hair surface has a negative charge, so it adsorbs cationic surfactants. For this reason, hair conditioners and also hair sunscreens contain cationic surfactants, mainly quaternary ammonium salts, which absorb UV light, protecting hair surface from dryness and oxidation. Contrarily, shampoo formulations are composed by anionic surface-active agents, which can induce, in many cases, hair protein loss, hair dryness, opacity and difficulty of handling. In order to know if biosurfactant extract, obtained from CSL, could be adsorbed on hair, its ionic behavior was evaluated by using anionic and cationic resins using a solid/liquid ratio of 1:10 at room temperature. After that, adsorption experiments using human hair were established at room temperature with hair/biosurfactant solution ratio of 1:50. [...]The financial support from the Spanish Ministry of Economy and Competitiveness (FEDER funds under the project CTM2015-68904) and L. Rodríguez-López is grateful for her predoctoral fellowship supported by the University of Vigo (Spain)