PTF 10bzf (SN 2010ah): A Broad-Line Ic Supernova Discovered by the Palomar Transient Factory

We present the discovery and follow-up observations of a broad-line Type Ic supernova (SN), PTF 10bzf (SN 2010ah), detected by the Palomar Transient Factory (PTF) on 2010 February 23. The SN distance is ≅218 Mpc, greater than GRB 980425/SN 1998bw and GRB 060218/SN 2006aj, but smaller than the other SNe firmly associated with gamma-ray bursts (GRBs). We conducted a multi-wavelength follow-up campaign with Palomar 48 inch, Palomar 60 inch, Gemini-N, Keck, Wise, Swift, the Allen Telescope Array, Combined Array for Research in Millimeter-wave Astronomy, Westerbork Synthesis Radio Telescope, and Expanded Very Large Array. Here we compare the properties of PTF 10bzf with those of SN 1998bw and other broad-line SNe. The optical luminosity and spectral properties of PTF 10bzf suggest that this SN is intermediate, in kinetic energy and amount of ^(56)Ni, between non-GRB-associated SNe like 2002ap or 1997ef, and GRB-associated SNe like 1998bw. No X-ray or radio counterpart to PTF 10bzf was detected. X-ray upper limits allow us to exclude the presence of an underlying X-ray afterglow as luminous as that of other SN-associated GRBs such as GRB 030329 or GRB 031203. Early-time radio upper limits do not show evidence for mildly relativistic ejecta. Late-time radio upper limits rule out the presence of an underlying off-axis GRB, with energy and wind density similar to the SN-associated GRB 030329 and GRB 031203. Finally, by performing a search for a GRB in the time window and at the position of PTF 10bzf, we find that no GRB in the interplanetary network catalog could be associated with this SN

Constraints on a scale-dependent bias from galaxy clustering

We forecast the future constraints on scale-dependent parametrizations of galaxy bias and their impact on the estimate of cosmological parameters from the power spectrum of galaxies measured in a spectroscopic redshift survey. For the latter we assume a wide survey at relatively large redshifts, similar to the planned Euclid survey, as baseline for future experiments. To assess the impact of the bias we perform a Fisher matrix analysis and we adopt two different parametrizations of scale-dependent bias. The fiducial models for galaxy bias are calibrated using a mock catalogs of H$\alpha$ emitting galaxies mimicking the expected properties of the objects that will be targeted by the Euclid survey. In our analysis we have obtained two main results. First of all, allowing for a scale-dependent bias does not significantly increase the errors on the other cosmological parameters apart from the rms amplitude of density fluctuations, $\sigma_{8}$, and the growth index $\gamma$, whose uncertainties increase by a factor up to two, depending on the bias model adopted. Second, we find that the accuracy in the linear bias parameter $b_{0}$ can be estimated to within 1-2\% at various redshifts regardless of the fiducial model. The non-linear bias parameters have significantly large errors that depend on the model adopted. Despite of this, in the more realistic scenarios departures from the simple linear bias prescription can be detected with a $\sim2\,\sigma$ significance at each redshift explored. Finally, we use the Fisher Matrix formalism to assess the impact of assuming an incorrect bias model and found that the systematic errors induced on the cosmological parameters are similar or even larger than the statistical ones.Comment: new section added; conclusions unchanged; accepted for publication in PR

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels

There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs. Examples of such functions are documented in the pancreas, but recent results suggest that GABA may act in a similar way in the pituitary, in which GABA receptors are expressed and pituitary growth hormone (GH) cells provide a source of GABA. We hypothesised that GABA secreted in somatotropes may act as an autoregulatory signaling molecule. To test this hypothesis we first examined the nature of GABA receptors expressed by GH cells. RT-PCR analysis demonstrated that GABA-B receptor subunits R1 and R2 are present in the whole rat pituitary. Laser microdissection of immunostained GH cells, followed by RT-PCR as well as immunoelectron microscopy, showed that GABA-B receptors are expressed on somatotropes. To investigate GABA-B receptor function in somatotropes, we used rat GH3 adenoma cells, which, like pituitary GH cells, express GABA-B R1 and R2 (as assessed by RT-PCR and immunoelectron microscopy) and produce GABA (checked by high performance liquid chromatography). After inhibition of endogenous GABA synthesis, GH production was stimulated by baclofen, a chromatography). After inhibition of endogenous GABA synthesis, GH production was stimulated by bactofen, a GABA-B receptor agonist. By contrast, blocking GABA-B receptors by an antagonist, phaclofen, decreased GH levels. We conclude that in GH-producing cells, GABA acts as an autocrine factor via GABA-B receptors to control GH levels. Copyright (C) 2002 S. KargerAG, Basel

Sinonasal angioleiomyoma with adipocyte differentiation: clinicopathologic study of 2 cases and review of the literature

Angioleiomyoma (ALM) is a benign tumor of the skin and soft tissues composed of well differentiated smooth muscle cells arranged around and among many vascular channels. Few cases have been reported in the sinonasal region, where ALM may show a variable amount of mature adipose tissue that may make hard the distinction from angiomyolipoma. We report here two cases that presented with a three- and six-month history of left nasal obstruction respectively. In both patients, clinical examination and imaging studies failed to reveal features of tuberous sclerosis complex and demonstrated a mass obliterating the nasal cavity arising from the inferior turbinate. Both masses were endoscopically excised. Pathologic analysis revealed highly vascularized tumors composed of well differentiated smooth muscle cells intermingled with a variable number of mature adipocytes. Immunostaining for melanocytic markers was negative. Based on these findings, both tumors were diagnosed as sinonasal-ALM with adipocytic differentiation. These two cases indicate that both clinical data (i.e. absence of features of tuberous sclerosis complex) and immunohistochemistry (i.e. absence of melanocytic markers) are mandatory for the recognition of sinonasal-ALM with adipocytic differentiation. The term angiomyolipoma to identify these lesions is confusing and should be abandoned

Adaptation of the C4 grass Panicum maximum to defoliation is related to plasticity of N uptake, mobilisation and allocation patterns.

Dry mass production and persistence of Panicum maximum pastures depends on nitrogen supply. Defoliation influences N uptake and allocation patterns yet its effects on plasticity of N dynamics in P. maximum have not been investigated. Stable isotopes of N (15N) were used in order to test the hypothesis that defoliation in terms of proportion of the leaf area removed effects N mobilisation, uptake and allocation patterns in P. maximum. The plants were initially cut weekly to a height of either 0.15 m or 0.30 m for seven weeks. Eight weeks after the first defoliation, all plants were defoliated for a final time to remove 0, 25, 50, 75 or 100 % of the area of each individual leaf blade of the main tiller. Root N uptake was reduced when all leaf area was removed, but more lenient defoliation improved N uptake due to a positive effect on specific N uptake. Young leaves, side tillers and roots were the main sinks for N from root uptake. Roots of P. maximum became a net source of N for mobilisation immediately after severe defoliation. Root uptake was the main source of N for new growth in P. maximum plants. Allocation pattern of mobilised N was different from that of N derived from root uptake. It was concluded that adaptation of P. maximum to defoliation is related to plasticity of N uptake, mobilisation and allocation, but changes in N dynamics did not offset negative impacts of complete defoliation of the plants