7 research outputs found
Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study
International audienc
Supplementary Material for: Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study
<p><b><i>Background:</i></b> Adipose tissue is an abundant source of
mesenchymal stem cells, called adipose-derived stem cells, which have
anti-inflammatory and trophic effects to enhance overall tissue repair. <b><i>Objective:</i></b> To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers. <b><i>Methods:</i></b>
Prospective pilot study in 1 French dermatology department. Ten
patients with a hypertensive leg ulcer were enrolled from April 2013 to
June 2015. The primary end point was the wound closure rate at each
follow-up visit. The secondary end points were wound characteristics,
pain assessment and adverse events. <b><i>Results:</i></b> One patient,
the only smoker, was lost to follow-up at month 5 (M5). For the 9
non-smokers, wound surfaces constantly and significantly decreased: the
median wound closure rate was 73.2% at M3 and 93.1% at M6, <i>p</i> < 0.001. The median wound closure rate of the 10 patients was 63.2% at M3, <i>p</i>
< 0.001. Percentages of fibrin and necrosis decreased, granulation
tissue increased significantly. Pain rapidly and significantly
decreased. No recurrence or adverse event was observed. <b><i>Conclusion:</i></b>
Our data suggest that autologous adipose tissue grafting induces pain
relief and promotes wound healing with a good skin quality. Large
prospective controlled randomized studies are required to confirm these
results.</p
A single typical trichoscopic feature is predictive of tinea capitis: a prospective multicentre study
International audienc