5,700 research outputs found

    Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

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    AbstractThe establishment of relative size of organs and structures is paramount for attaining final form and function of an organism. Importantly, variation in the proportions of structures frequently underlies adaptive change in morphology in evolution and maybe a common mechanism underlying selection. However, the mechanism by which growth is integrated within tissues during development to achieve proper proportionality is poorly understood. We have shown that signaling by potassium channels mediates coordinated size regulation in zebrafish fins. Recently, calcineurin inhibitors were shown to elicit changes in zebrafish fin allometry as well. Here, we identify the potassium channelkcnk5bas a key player in integrating calcineurin’s growth effects, in part through regulation of the cytoplasmic C-terminus of the channel. We propose that the interaction between Kcnk5b and calcineurin acts as a signaling node to regulate allometric growth. Importantly, we find that this regulation is epistatic to inherent mechanisms instructing overall size as inhibition of calcineurin is able to bypass genetic instruction of size as seen insofand wild-type fins, however, it is not sufficient to re-specify positional memory of size of the fin. These findings integrate classic signaling mediators such as calcineurin with ion channel function in the regulation of size and proportion during growth.</jats:p

    Agricultural gypsum for alkali land reclamation

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    Online access for this thesis was created in part with support from the Institute of Museum and Library Services (IMLS) administered by the Nevada State Library, Archives and Public Records through the Library Services and Technology Act (LSTA). To obtain a high quality image or document please contact the DeLaMare Library at https://unr.libanswers.com/ or call: 775-784-6945.It has been established that a considerable amount of the saline soils mentioned above are, in fact, saline-alkali lands having exchangeable sodium percentages appreciably greater than 15 and having conductivities of the saturation extract greater than 4 millimhos per contimetor. Most soils in the western part of the United States contain some adsorbed sodium in the exchange-complex of the clay colloids. When this this exchangeable - sodium percentage exceeds 15, then the soil is classified as alkali. When it appreciably exceeds this value, the soil is in need of chemical amendment in addition to leaching to bring about reclamation. If adequate quantities of some corrective mineral such as gypsum are not present in the surface soil, thon it must be added. Otherwise, leaching may remove the soluble salts, cause an increase in pH value and produce soil exchanges which would reduce infiltration rates, a circumstance' which would defeat efforts towards reclamation. Investigations so far conducted have indicated that soils around Logarou Lagoon in the Arta plain (Pachykalamos area) and those on the lower Acheloos River delta (Neochori aroa) are of this typo. Thyy also indicate that considerable applications of gypsum will be required and that this might easily be a controlling factor in economic feasibility of reclamation. Until this year the cost of agricultural gypsum delivered to the two sites of use mentioned above has been approximately $9,00 - 10,00/M.T» The writer considered this quite expansive and investigations were started to determine what actual delivered costs should be under a well - planned mining, processing and distribution arrangement. This report analyzes costs of production and distribution under two different sets of conditions

    Clavos intramedulares vs. placas de osteosíntesis para fracturas de fémur. Análisis por elementos finitos

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    La estabilización interna de fracturas de la diáfisis femoral se realiza mediante la implantación de clavos intramedulares o placas de osteosíntesis. El objetivo de este estudio es realizar una comparación biomecánica por elementos finitos de ambos implantes y así desarrollar una herramienta preclínica para guiar a los cirujanos en la elección del método de estabilización más adecuado para cada fractura. Se malló un fémur entero en el cual se practicó una fractura de 1mm ó 3mm en la diáfisis. Los modelos de placa y clavo se mallaron a partir de la geometría de los implantes, para el clavo se realizaron dos modelos con diámetros distintos (11 y 13 mm). El estudio incluye simulaciones en dos etapas de regeneración de la fractura (con modulo de elasticidad en la fractura de 1 MPa ó 10 MPa), con implantes de acero inoxidable y titanio. Las cargas aplicadas simulan el apoyo monopodal e incluyen la actuación de la cadera, y los músculos abductores, psoas ilíaco e iliotibial. Los resultados muestran que la tensión en los implantes aumenta con el tamaño de la fractura y disminuye con su módulo. Los clavos tienden a inducir más deformación en la fractura que las placas. El diámetro de los clavos influye en la tensión inducida en el hueso y en la deformación en la fractura, los resultados de los clavos más anchos tienden a los resultados de las placas

    Coherent Population Trapping of Electron Spins in a Semiconductor

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    In high-purity n-type GaAs under strong magnetic field, we are able to isolate a lambda system composed of two Zeeman states of neutral-donor bound electrons and the lowest Zeeman state of bound excitons. When the two-photon detuning of this system is zero, we observe a pronounced dip in the excited-state photoluminescence indicating the creation of the coherent population-trapped state. Our data are consistent with a steady-state three-level density-matrix model. The observation of coherent population trapping in GaAs indicates that this and similar semiconductor systems could be used for various EIT-type experiments.Comment: 5 pages, 4 figures replaced 6/25/2007 with PRL versio

    Clavos intramedulares vs. placas de osteosíntesis para fracturas de fémur: Análisis por elementos finitos.

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    La estabilización interna de fracturas de la diáfisis femoral se realiza mediante la implantación de clavos intramedulares o placas de osteosíntesis. El objetivo de este estudio es realizar una comparación biomecánica por elementos finitos de ambos implantes y así desarrollar una herramienta preclínica para guiar a los cirujanos en la elección del método de estabilización más adecuado para cada fractura. Se malló un fémur entero en el cual se practicó una fractura de 1mm ó 3mm en la diáfisis. Los modelos de placa y clavo se mallaron a partir de la geometría de los implantes, para el clavo se realizaron dos modelos con diámetros distintos (11 y 13 mm). El estudio incluye simulaciones en dos etapas de regeneración de la fractura (con modulo de elasticidad en la fractura de 1 MPa ó 10 MPa), con implantes de acero inoxidable y titanio. Las cargas aplicadas simulan el apoyo monopodal e incluyen la actuación de la cadera, y los músculos abductores, psoas ilíaco e iliotibial. Los resultados muestran que la tensión en los implantes aumenta con el tamaño de la fractura y disminuye con su módulo. Los clavos tienden a inducir más deformación en la fractura que las placas. El diámetro de los clavos influye en la tensión inducida en el hueso y en la deformación en la fractura, los resultados de los clavos más anchos tienden a los resultados de las placas

    Computational Methods for Failure Analysis and Life Prediction

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    This conference publication contains the presentations and discussions from the joint UVA/NASA Workshop on Computational Methods for Failure Analysis and Life Prediction held at NASA Langley Research Center 14-15 Oct. 1992. The presentations focused on damage failure and life predictions of polymer-matrix composite structures. They covered some of the research activities at NASA Langley, NASA Lewis, Southwest Research Institute, industry, and universities. Both airframes and propulsion systems were considered
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