Constraints on a scale-dependent bias from galaxy clustering

We forecast the future constraints on scale-dependent parametrizations of galaxy bias and their impact on the estimate of cosmological parameters from the power spectrum of galaxies measured in a spectroscopic redshift survey. For the latter we assume a wide survey at relatively large redshifts, similar to the planned Euclid survey, as baseline for future experiments. To assess the impact of the bias we perform a Fisher matrix analysis and we adopt two different parametrizations of scale-dependent bias. The fiducial models for galaxy bias are calibrated using a mock catalogs of H$\alpha$ emitting galaxies mimicking the expected properties of the objects that will be targeted by the Euclid survey. In our analysis we have obtained two main results. First of all, allowing for a scale-dependent bias does not significantly increase the errors on the other cosmological parameters apart from the rms amplitude of density fluctuations, $\sigma_{8}$, and the growth index $\gamma$, whose uncertainties increase by a factor up to two, depending on the bias model adopted. Second, we find that the accuracy in the linear bias parameter $b_{0}$ can be estimated to within 1-2\% at various redshifts regardless of the fiducial model. The non-linear bias parameters have significantly large errors that depend on the model adopted. Despite of this, in the more realistic scenarios departures from the simple linear bias prescription can be detected with a $\sim2\,\sigma$ significance at each redshift explored. Finally, we use the Fisher Matrix formalism to assess the impact of assuming an incorrect bias model and found that the systematic errors induced on the cosmological parameters are similar or even larger than the statistical ones.Comment: new section added; conclusions unchanged; accepted for publication in PR

An autocrine role for pituitary GABA: Activation of GABA-B receptors and regulation of growth hormone levels

There is increasing evidence suggesting that the neurotransmitter gamma-aminobutyric acid (GABA) is a local factor involved in the regulation of endocrine organs. Examples of such functions are documented in the pancreas, but recent results suggest that GABA may act in a similar way in the pituitary, in which GABA receptors are expressed and pituitary growth hormone (GH) cells provide a source of GABA. We hypothesised that GABA secreted in somatotropes may act as an autoregulatory signaling molecule. To test this hypothesis we first examined the nature of GABA receptors expressed by GH cells. RT-PCR analysis demonstrated that GABA-B receptor subunits R1 and R2 are present in the whole rat pituitary. Laser microdissection of immunostained GH cells, followed by RT-PCR as well as immunoelectron microscopy, showed that GABA-B receptors are expressed on somatotropes. To investigate GABA-B receptor function in somatotropes, we used rat GH3 adenoma cells, which, like pituitary GH cells, express GABA-B R1 and R2 (as assessed by RT-PCR and immunoelectron microscopy) and produce GABA (checked by high performance liquid chromatography). After inhibition of endogenous GABA synthesis, GH production was stimulated by baclofen, a chromatography). After inhibition of endogenous GABA synthesis, GH production was stimulated by bactofen, a GABA-B receptor agonist. By contrast, blocking GABA-B receptors by an antagonist, phaclofen, decreased GH levels. We conclude that in GH-producing cells, GABA acts as an autocrine factor via GABA-B receptors to control GH levels. Copyright (C) 2002 S. KargerAG, Basel

On the effects of strong ionization in medium-order harmonic generation

Strong ionization of the gas medium has significant effects in the process of medium-order harmonic generation. The combined effect of neutral atom depletion and defocusing of the pump beam due to the intensity-dependent density of free electrons, significantly modifies the conversion characteristics and efficiency. For moderate harmonic orders, the yield is optimized for well-defined values of the pump laser intensity that do not depend on the order or on the focusing geometry, but only on the ionization potential of the gas. In particular focusing conditions, the ionization-induced defocusing can effectively guide the pump beam along channels of optimum intensity, thus enhancing the overall conversion efficiency. We demonstrate that a very simple model is able to reproduce all our experimental results in a surprisingly good way

GRB 970228 Within the EMBH Model

We consider the gamma-ray burst of 1997 February 28 (GRB 970228) within the ElectroMagnetic Black Hole (EMBH) model. We first determine the value of the two free parameters that characterize energetically the GRB phenomenon in the EMBH model, that is to say the dyadosphere energy, $E_{dya}=5.1\times10^{52}$ ergs, and the baryonic remnant mass $M_{B}$ in units of $E_{dya}$, $B=M_{B}c^{2}/E_{dya}=3.0\times10^{-3}$. Having in this way estimated the energy emitted during the beam-target phase, we evaluate the role of the InterStellar Medium (ISM) number density (n$_{ISM}$) and of the ratio ${\cal R}$ between the effective emitting area and the total surface area of the GRB source, in reproducing the observed profiles of the GRB 970228 prompt emission and X-ray (2-10 keV energy band) afterglow. The importance of the ISM distribution three-dimensional treatment around the central black hole is also stressed in this analysis.Comment: 4 pages, 1 figure, to appear in the Proceedings of the Los Alamos "Gamma Ray Burst Symposium" in Santa Fe, New Mexico, September 8-12 2003 (AIP Conf. Ser.), CHAPTER: GRB Connection to Supernova

Phenotypic and Gene Expression Profiles of Embryo Development of the Ascidian Ciona robusta Exposed to Dispersants

Within EU approval policies, most dispersant ecotoxicity testing considers lethal concentrations for marine adult species, overlooking the embryotoxicological effects. Here we studied the ecotoxicity of two commercial dispersant formulations (dispersant A and B) on the embryogenesis of the ascidian Ciona robusta. Embryotoxicity and phenotypic alterations stated that dispersant B resulted more toxic than A (EC50 value of 44.30 and 160 µg mL−1, respectively) and induced severe larvae malformations at lower concentrations. Furthermore, the analysis of genes involved in different cellular response pathways indicated that those belonging to biotransformation were upregulated by dispersant A treatment, likely related to the presence of hydrocarbons. Instead, dispersant B induced cas8 gene downregulation, probably as a result of the prolonged exposure to mixture components. Our preliminary findings support the use of the C. robusta embryotoxicity test as a valuable tool for dispersant approval procedures, by providing sub-lethal responses on marine invertebrates closely related to vertebrates

Resposta de pastagens de capim-marandu em solo de cerrado à adubação com nitrogênio, em condições de sequeiro. ou sob irrigação

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