And Yet they Co-Move! Public Capital and Productivity in OECD.

In this paper we add to the debate on the public capital-productivity link by applying very recent developments in the panel time series literature that take into account cross sectional correlation in non-stationary panels. In particular we evaluate the productive effect of public capital by estimating various production functions on a panel of 21 OECD countries over the period 1975-2002. Our results suggest that public capital has a positive long run impact on output, with elasticities that range between 0.05-0.15, depending on model specification. These findings are robust to the existence of spillover effects from public capital investments in other countries and to the inclusion of other productivity determinants, like human capital, the stock of patents and R&D capital. Finally, we do not find any important effect of public capital on GDP in the short run: this suggests that public infrastructure investments might not be a powerful countercyclical policy instrument

Simultaneous observation of wind shears and misalignments from rotor loads

A wind turbine is used in this paper as a sensor to measure the wind conditions at the rotor disk. In fact, as any anisotropy in the wind will lead to a specific signature in the machine response, by inverting a response model one may infer its generating cause, i.e. the wind. Control laws that exploit this knowledge can be used to enhance the performance of a wind turbine or a wind power plant. This idea is used in the present paper to formulate a linear implicit model that relates wind states and rotor loads. Simulations are run in both uniform and turbulent winds, using a high-fidelity aeroservoleastic wind turbine model. Results demonstrate the ability of the proposed observer in detecting the horizontal and vertical wind misalignments, as well as the vertical and horizontal shears

Wake center position tracking using downstream wind turbine hub loads

Having an improved awareness of the flow within a wind farm is useful for power harvesting maximization, load minimization and design of wind farm layout. Local flow information at each wind turbine location can be obtained by using the response of the wind turbines, which are consequently used as distributed sensors. This paper proposes the use of hub loads to track the position of wakes within a wind farm. Simulation experiments conducted within a high-fidelity aeroservoelastic environment demonstrate the performance of the new method

Cyclic Pitch Control for the Reduction of Ultimate Loads on Wind Turbines

In this paper we study the use of individual blade pitch control as a way to reduce ultimate loads. This load alleviation strategy exploits the fact that cyclic pitching of the blades induces in general a reduction of the average loading of a wind turbine, at least for some components as the main bearing, the yaw bearing, or the tower. When ultimate loads are generated during shutdowns, the effect of the use of cyclic pitch results in reduced peak loads. In fact, as the machine starts from a less stressed condition, the response to an extreme gust or other event will result in reduced loading on its components. This form of load mitigation can be seen as a preventative load mitigation strategy: the effect on load reduction is obtained without the need to detect and react to an extreme event, but by simply unloading the machine so that, in case an extreme event happens, the result will be less severe. The effect of peak load mitigation by preventative cyclic pitch is investigated with reference to a multi-MW wind turbine, by using high-fidelity aeroelastic simulations in a variety of operating conditions

Verification and Calibration of a Reduced Order Wind Farm Model by Wind Tunnel Experiments

In this paper an adaptation of the FLORIS approach is considered that models the wind flow and power production within a wind farm. In preparation to the use of this model for wind farm control, this paper considers the problem of its calibration and validation with the use of experimental observations. The model parameters are first identified based on measurements performed on an isolated scaled wind turbine operated in a boundary layer wind tunnel in various wind-misalignment conditions. Next, the wind farm model is verified with results of experimental tests conducted on three interacting scaled wind turbines. Although some differences in the estimated absolute power are observed, the model appears to be capable of identifying with good accuracy the wind turbine misalignment angles that, by deflecting the wake, lead to maximum power for the investigated layouts

Automatic detection and correction of pitch misalignment in wind turbine rotors

In this work, a new algorithm is presented to correct for pitch misalignment imbalances of wind turbine rotors. The method uses signals measured in the fixed frame of the machine, typically in the form of accelerations or loads. The amplitude of the one per revolution signal harmonic is used to quantify the imbalance, while its phase is used to locate the unbalanced blade(s). The near linearity of the unknown relationship between harmonic amplitude and pitch misalignment is used to derive a simple algorithm that iteratively rebalances the rotor. This operation is conducted while the machine is in operation, without the need for shutting it down. The method is not only applicable to the case of a single misaligned blade, but also to the generic case of multiple concurrent imbalances. Apart from the availability of acceleration or load sensors, the method requires the ability of the rotor blades to be commanded independently from one another, which is typically possible on many modern machines. The new method is demonstrated in a realistic simulation environment using an aeroservoelastic wind turbine model in a variety of wind and operating conditions.</p

Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products

Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective immunoregulatory networks or to reprogramme defective ones. In contrast to acute inflammation, chronic inflammation appears to have no beneficial role, but is a state of sustained immune reactivity in the presence or progression of a disease process. This results in an escalating cycle of tissue damage followed by unproductive tissue repair, breaks in self-tolerance, malignant transformation or deleterious changes in tissue morphology and function. Such inappropriate immune reactivity is an underlying characteristic, either in initiation or maintenance, of a diverse range of disease states including chronic infection, autoimmunity, allergy, cancer, vascular disease and metabolic alterations. Evidence is presented that the inappropriate immune reactivity is due, at least to some extent, to failures in the establishment of immunoregulatory networks as a result of hygiene-related factors. Such networks are the result of activation of antigen-presenting cells, principally dendritic cells, by molecular patterns of micro-organisms encountered sequentially during life and establishing the ‘biography’ of the immune system.Laboratorio de Investigaciones del Sistema Inmun

Chronic inflammation as a manifestation of defects in immunoregulatory networks: implications for novel therapies based on microbial products

Based on a unifying theory presented here, it is predicted that the immune defects resulting in chronic inflammation rather than effective immune responses could be rectified by the therapeutic use of agents prepared from micro-organisms. With appropriate molecular patterns, these should be able to induce protective immunoregulatory networks or to reprogramme defective ones. In contrast to acute inflammation, chronic inflammation appears to have no beneficial role, but is a state of sustained immune reactivity in the presence or progression of a disease process. This results in an escalating cycle of tissue damage followed by unproductive tissue repair, breaks in self-tolerance, malignant transformation or deleterious changes in tissue morphology and function. Such inappropriate immune reactivity is an underlying characteristic, either in initiation or maintenance, of a diverse range of disease states including chronic infection, autoimmunity, allergy, cancer, vascular disease and metabolic alterations. Evidence is presented that the inappropriate immune reactivity is due, at least to some extent, to failures in the establishment of immunoregulatory networks as a result of hygiene-related factors. Such networks are the result of activation of antigen-presenting cells, principally dendritic cells, by molecular patterns of micro-organisms encountered sequentially during life and establishing the "biography" of the immune system.Fil: Bottasso, Oscar Adelmo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Docena, Guillermo H.. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigación y Desarrollo en Criotecnología de Alimentos. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigación y Desarrollo en Criotecnología de Alimentos; ArgentinaFil: Stanford, J. L.. University College London; Estados UnidosFil: Grange, J. M.. University College London; Estados Unido

Cyclic pitch control for the reduction of ultimate loads on wind turbines

In this paper we study the use of individual blade pitch control as a way to reduce ultimate loads. This load alleviation strategy exploits the fact that cyclic pitching of the blades induces in general a reduction of the average loading of a wind turbine, at least for some components as the main bearing, the yaw bearing, or the tower. When ultimate loads are generated during shutdowns, the effect of the use of cyclic pitch results in reduced peak loads. In fact, as the machine starts from a less stressed condition, the response to an extreme gust or other event will result in reduced loading on its components. This form of load mitigation can be seen as a preventative load mitigation strategy: the effect on load reduction is obtained without the need to detect and react to an extreme event, but by simply unloading the machine so that, in case an extreme event happens, the result will be less severe. The effect of peak load mitigation by preventative cyclic pitch is investigated with reference to a multi-MW wind turbine, by using high-fidelity aeroelastic simulations in a variety of operating conditions

Age-related increase in resistance to acute Trypanosoma cruzi infection in rats is associated with an appropriate antibody response

Inoculation at weaning with Trypanosoma cruzi in inbred 'l' rats resulted in a self-resolving acute infection characterized by marked parasitaemias, whereas challenge to adult rats revealed a mild disease with extremely low parasitaemias. To explore the mechanisms underlying such age-associated differences in disease outcome, we analysed the in vitro replication of T. cruzi, nitric oxide and tumour necrosis factor-α (TNF-α) production in peritoneal macrophages (PMs), the serum concentrations of the specific immunoglobulins (Igs) IgM and IgG, antibodies exhibiting lytic activity against bloodstream forms of T. cruzi and circulating levels of nitrate, TNF-α and interferon-γ (IFN-γ). Macrophages from young rats were as effective as their adult counterparts for restraining intracellular parasite replication. When stimulated with IFN-γ, culture supernatants from young PMs contained higher amounts of nitrite and TNF-α. Serum samples from 4 and 7 days post infection revealed easily detectable amounts of nitrate, with values being further augmented by day 7 post infection and significantly higher in the young group. TNF-α levels were only detected in the young group by day 7 post infection. Both groups had increased amounts of IFN-γ in their sera, although in adult rats, this trend was followed by a significant drop at day 7, with young rats showing values still higher by the same time point evaluation. In contrast, young rats presented significantly lower levels of IgM and IgG antibodies during the first week of infection. Increased resistance in adult rats seems to be the result of a more appropriate antibody production.Fil: Pascutti, María Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Bottasso, Oscar Adelmo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; ArgentinaFil: Hourquescos, M. C.. Universidad Nacional de Rosario; ArgentinaFil: Wietzerbin, Jeanne. Institute Curie; FranciaFil: Revelli, Silvia Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Inmunología Clinica y Experimental de Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Instituto de Inmunología Clinica y Experimental de Rosario; Argentin