Benign breast diseases: experience at a teaching hospital in rural India

Background: Though benign breast diseases are very common with nearly 1/3 of women suffering some time during their life time, not many studies have focused on this entity, especially in rural areas. Our teaching hospital situated amongst the villages in rural part of India provided the right background for the study.  Objective: To determine the frequency of benign breast diseases in a teaching hospital situated in the rural setting and to analyze the role of triple assessment in assessing benign breast diseases.Study design: Prospective, descriptive study.Setting: MVJ Medical College and Research Hospital, Hoskote, Bangalore Rural district, Karnataka, India.Method of study: Data including age, complaints, clinical examination, radiological investigations and histopathological diagnosis was collected from patients presenting to the department of surgery with breast complaints. Patients with carcinoma of the breast were excluded from the study.Results: A total of 110 patients were studied between November 2009 to March 2011. Mean age of patients was 28.6 years. Fibroadenoma was the most common diagnosis in 56.4% followed by fibroadenosis in 20.9%. There was one case each of lipoma, tuberculosis and duct ectasia and two cases of atypical ductal hyperplasia. The sensitivity of clinical diagnosis in our study was 91.1% and FNAC was 100% accurate in all patients with fibroadenoma but had a sensitivity of only 78% in the diagnosis of fibroadenosis. Only 3.3% of cases of fibroadenoma were treated conservatively

<i>p</i>H dependent axial ligation of alkyl(aquo)cobaloximes by amines: Synthesis, isolation and characterization of alkyl(ligand)cobaloximes

1409-1416Equilibria of the axial ligation of methyl and ethyl(aquo)cobaloximes by various aliphatic amines (methylamine, ethylamine, propylamine, butylamine, pentylamine, hexylamine, cyclopentylamine, cyclohexylamine, cycloheptylamine, N,N-dimethylamine and N,N-di ethylamine) have been measured spectrophotometrically in aqueous solutions of ionic strength 1.0 M (KCl) at 25 °C as a function of pH. The order of equilibrium constants is discussed based on the basicity and steric factors. In addition to above, some of the methyl and ethyl (ligand)cobaloximes have been synthesized and characterized by elemental analysis, UV, IR and 1H NMR spectra

The hymenopterous parasitoids of the diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), on cruciferous vegetables in Delhi, India

Abstract Background The diamondback moth (DBM), Plutella xylostella (L.) (Lepidoptera: Plutellidae), is a serious and economically important pest of crucifers in Delhi, India. Larvae and pupae of the pest were collected from the cabbage, cauliflower and broccoli crops grown in vegetable fields at the farm of ICAR-Indian Agricultural Research Institute (ICAR-IARI), New Delhi-110012, from December 2021 to June 2022. The larvae and pupae of the pest were transferred to the laboratory and reared for emergence of parasitoids’ adults at 25 ± 0.5 °C and RH 70 ± 5%. Results Four parasitoid species were emerged, viz. Apanteles mohandasi Sumodan & Narendran 1990, Cotesia vestalis (Haliday, 1834), Diadegma insulare (Cresson, 1865) and Diadromus collaris (Gravenhorst, 1829). Among them, A. mohandasi, C. vestalis and D. collaris were reported for the first time in Delhi, whereas D. insulare (Hymenoptera: Ichneumonidae) is recorded here for the first time in India. Additionally, the first record of parasitism by A. mohandasi on P. xylostella from Delhi was established. The highest parasitism percentage was that of C. vestalis and D. collaris. Moreover, higher parasitism rate was recorded during May 2022 in organically cultivated fields. The parasitism percentage by A. mohandasi, C. vestalis, D. insulare and D. collaris was 7.5, 22.5, 12.5 and 15%, respectively. Conversely, in conventionally farmed fields, the parasitism rates were 3.57, 16.67, 10 and 13.33%, respectively. Conclusion The use of biological control agents particularly the parasitoids in the IPM program of P. xylostella should be considered, thereby reducing reliance on insecticides and increasing the efficacy of hymenopteran parasitoids

Coenzyme B₁₂ model studies: Equilibria and kinetics of axial ligation of trifluoroethyl(aquo)cobaloximes by N donor ligands

2081-2086Equilibria and kinetics of the reaction of trifluoroethyl(aquo)cobaloximes with imidazole and substituted imidazoles have been studied as a function of pH at 25°C, 1.0 M ionic strength(KCl) by UV -vis spectrophotometry. Comparison of equillibrium constants with respect to ligand are in the order K1-Meimd> KImd > K2-Meimd > K1,2-Meimd > K2-EtiMD which are correlated to basicity and steric factors. The equilibrium constants are correlated to the softness and ability to form dπ-pπ back bonding

Design and mathematical modelling of Electric Vehicle

A model which is based on design will reduce the development cost of the system. There are different phases associated with complex models for systems like Electric Vehicles, these include Functional Specification definitions, Design specification, Test and authenticate and implementation. The case study done in this paper will be including only first two stages. The results will help to understand how the system designer can take decisions using simulation output. Simulation is a very complicated task which can represent simple design with precision and complex design with great accuracy that is almost near to the practical model. There is a compromise when making decisions with respect to precision and design complexity. It is always recommended to consider accurate models but when parameters are considered it is very difficult to determine parameters preferably in first stage of the model development and even the simulation of these accurate model is very slow. Hence a more detailed level of simulation model is needed. So, the system designer needs a complete overview of system power flow in the initial level of modelling. In the second level there is a need of designing more accurate model of different systems in which choosing an appropriate parameter for energy management system and power converters is needed. In this paper it can be clarified that a detailed design will validate the system’s behaviour with great accuracy and to conduct other adoptions as requires

Amino groups of chitosan are crucial for binding to a family 32 carbohydrate binding module of a chitosanase from Paenibacillus elgii

We report here the role and mechanism of specificity of a family 32 carbohydrate binding module (CBM32) of a glycoside hydrolase family 8 chitosanase from Paenibacillus elgii (PeCsn). Both the activity and mode of action of PeCsn toward soluble chitosan polymers were not different with/without the CBM32 domain of P. elgii (PeCBM32). The decreased activity of PeCsn without PeCBM32 on chitosan powder suggested that PeCBM32 increases the relative concentration of enzyme on the substrate and thereby enhanced enzymatic activity. PeCBM32 specifically bound to polymeric and oligomeric chitosan and showed very weak binding to chitin and cellulose. In isothermal titration calorimetry, the binding stoichiometry of 2 and 1 for glucosamine monosaccharide (GlcN) and disaccharide (GlcN)2, respectively, was indicative of two binding sites in PeCBM32. A three-dimensional model-guided site-directed mutagenesis and the use of defined disaccharides varying in the pattern of acetylation suggested that the amino groups of chitosan and the polar residues Glu-16 and Glu-38 of PeCBM32 play a crucial role for the observed binding. The specificity of CBM32 has been further elucidated by a generated fusion protein PeCBM32-eGFP that binds to the chitosan exposing endophytic infection structures of Puccinia graminis f. sp. tritici. Phylogenetic analysis showed that CBM32s appended to chitosanases are highly conserved across different chitosanase families suggesting their role in chitosan recognition and degradation. We have identified and characterized a chitosan-specific CBM32 useful for in situ staining of chitosans in the fungal cell wall during plant-fungus interaction

Application of soft computing algorithms for hybrid modular multilevel inverters

This study utilized Harris Hawk optimization to analyze the harmonic distortions of a symmetric capacitor based multilevel converter. The proposed multilevel converter uses identical and symmetric DC sources in its input. The proposed topology for a multilevel converter uses fewer switches than typical cascaded designs. It can output 9-level outputs and can be scaled up to higher levels. The proposed multilevel converter can be improved by implementing a low frequency pulse width modulation technique to reduce the stress on the switches. The optimization of the switching angles using Harris Hawk was able to solve the non-linear aspects of the Selective Harmonic Elimination Pulse Width Modulation. The output voltage's THD was compared with that of other optimization methods, such as ant colony and particle swarm. The comparison shows that the output THD of the Harris Hawk optimizer is lower than that of other methods, which is about 5 %, according to the standards of IEEE-519