Synergistic Accumulative Effect of Salicylic Acid and Dibutyl Phthalate on Paclitaxel Production in Corylus avellana Cell Culture

Suspension cell cultures of Corylus avellana were challenged with salicylic acid and its combined use with dibutyl phthalate solvent. Salicylic acid with concentrations of 12.5, 25 and 50 mg L–1 and 10% (v/v) dibutyl phthalate were used and added on day 8 and 10 of subculture, respectively. The results showed that growth, viability and protein content of cells were decreased by the treatments, compared to control. In all treatments, hydrogen peroxide content and lipid peroxidation rate of cells increased, compared to those of the control cells. Activity of phenylalanine ammonia-lyase increased by salicylic acid and, dibutyl phthalate exaggerated effect of salicylic acid. While flavonoids content decreased by the treatments, paclitaxel content increased significantly. The extracellular paclitaxel was more affected, compared to cell-associated paclitaxel and all treatments increased paclitaxel release and specific yield compared to that of the control. The most production of paclitaxel and specific yield of it were observed under effect of combined use of salicylic acid (50 mg L–1) and dibutyl phthalate, suggesting a synergistic accumulative effect

Chemical composition and antibacterial activity from essential oil of Artemisia sieberi Besser subsp. Sieberi in North of Iran

The chemical composition and antibacterial effect of Artemisia siberi essential oil were studied in this research. The composition of essential oil from aerial parts was analyzed by GC/MS and its antibacterial effect were determined by disc diffusion method. Artemisia ketone (48.5%), 1, 8-cineole (19.7%), selin-11-en-4-a-ol (4.6%) and lavandulon (2.8%) were the major constituents of this herbal medicine. Inhibitory zone against Pseudomonas aeroginosa, Staphylococcus aureus and Escherichia coli around discs contained 100 mg mL-1 of Artemisia siberi essential oil were 18, 13 and 12 mm, respectively. Further studies for the determination of and Pseudomonas infection in animal model are suggested. © 2007 Asian Network for Scientific Information

Datos adicionales sobre Haplozetes fusifer (Berlese, 1908) (Acari, Oribatida, Haplozetidae) de Irán

An oribatid mite of the family Haplozetidae, Haplozetes fusifer (Berlese, 1908) is redescribed on the basis of Iranian materials, including the first detailed descriptions of the gnathosoma and legs.Se redescribe un ácaro oribátido de la familia Haplozetidae, Haplozetes fusifer (Berlese, 1908), sobre la base de material iraní, incluyendo las primeras descripciones detalladas del gnatosoma y las patas

Nueva especie de Ramusella Hammer, 1962 (Acari, Oppiidae), de la provincia de Fars, Irán

A new species of oribatid mite of the family Oppiidae, Ramusella (Insculptoppia) farsi sp. nov., is described from Fars province, southern Iran. The new species is characterized by the fusiform sensillus, with ten long ciliae on its head; smooth notogastral setae, presence of seta c2, and four pairs of genital setae.Se describe una nueva especie de ácaro oribátido de la familia Oppiidae, Ramusella (Insculptoppia) farsi sp. nov., procedente de la provincia de Fars, sur de Irán. La nueva especie se caracteriza por el sensilo fusiforme con 10 largos cilios en su cabeza, setas notogastrales delgadas, presencia de seta c2 y cuatro pares de setas genitales

First record of Neoheegeria gigantea (Thys.: Phlaeothripidae) from Iran

گونه‌ی Neoheegeria gigantea (Priesner) از خانواده‌ی Phlaeothripidae و قبیله‌ی Haplothripini برای نخستین‌بار از ایران گزارش می‌شود. نمونه‌های این گونه در میان برگ‌های پوسیده‌ی زیر درختان بلوط جمع‌آوری شد که احتمالاً شکل تابستان‌گذران این گونه می‌باشد

First report of Banksinoma exobothridialis (Acari: Oribatida: Thyrisomidae) from Iran

The faunistic survey of oribatid mites, between 2008 and 2010, on the outskirts of the city of Shiraz led to the discovery of the species Banksinoma exobothridialis Bayartogtokh of the family Thyrisomidae. Both the species and the family are new to the Iranian fauna

Primary immunodeficiency disorders in Iran: Update and new insights from the third report of the national registry

Background: Primary immunodeficiency disorders (PID) are a group of heterogeneous disorders mainly characterized by severe and recurrent infections and increased susceptibility to malignancies, lymphoproliferative and autoimmune conditions. National registries of PID disorders provide epidemiological data and increase the awareness of medical personnel as well as health care providers. Methods: This study presents the demographic data and clinical manifestations of Iranian PID patients who were diagnosed from March 2006 till the March of 2013 and were registered in Iranian PID Registry (IPIDR) after its second report of 2006. Results: A total number of 731 new PID patients (455 male and 276 female) from 14 medical centers were enrolled in the current study. Predominantly antibody deficiencies were the most common subcategory of PID (32.3 %) and were followed by combined immunodeficiencies (22.3 %), congenital defects of phagocyte number, function, or both (17.4 %), well-defined syndromes with immunodeficiency (17.2 %), autoinflammatory disorders (5.2 %), diseases of immune dysregulation (2.6 %), defects in innate immunity (1.6 %), and complement deficiencies (1.4 %). Severe combined immunodeficiency was the most common disorder (21.1 %). Other prevalent disorders were common variable immunodeficiency (14.9 %), hyper IgE syndrome (7.7 %), and selective IgA deficiency (7.5 %). Conclusions: Registration of Iranian PID patients increased the awareness of medical community of Iran and developed diagnostic and therapeutic techniques across more parts of the country. Further efforts must be taken by increasing the coverage of IPIDR via electronically registration and gradual referral system in order to provide better estimation of PID in Iran and reduce the number of undiagnosed cases. © 2014 Springer Science+Business Media

Common Water Resources Conflict Analysis due to Agriculture Land Development Using Game Theory and GMCR+ (Case Study: Nazlouchay Basin in Urmia Lake Watershed)

IntroductionLand-use changes and development of irrigated agricultural lands are very important factors that affect natural resources such as the quantity and quality of water resources and the environment. Land use change is attributed to two major processes. The first process is the change in land cover, which is related to the expansion or limitation of the area of land used (such as pasture, agricultural or urban land). The second process is a change in land cover management type (for example, changes in irrigation, fertilizer use, crop type, harvesting methods or surface impermeability). Recently the Urmia lake has been accompanied by a reduction in water resources and the continuation of this process can completely cause to dry Urmia Lake. One of the approvals of the Iranian government after the formation of the National Working Group for the Lake Urmia restoration program was to prevent the development of agricultural lands in this watershed since 2014. Unfortunately, no serious and effective action has been taken in this case yet, and this process has progressed to cause conflicts in this region. Game theory is one of the most important methods used in modeling and analyzing water and environmental resources conflicts.Materials and MethodsIn the present study, using GMCR + software, the water resources conflicts arising from agricultural land development has been analyzed. In this conflict, by accurately identifying the set of decision-makers and their strategies in the conflict process (Regional Water Company, Agriculture Organization, Justice, and Profiteering Farmers), the model was executed with 4 players, 6 options, and 64 states. Players' performance was assessed once as ideal behavior (importance to the environment, sustainable development, and preference of long-term over short-term interests) and then as the use of completing a questionnaire. Then 4 states in the ideal behavior as equilibrium states and 7 states in the condition of using the questionnaire results were extracted as equilibrium states. The conflict was also examined in the coalition state of 3 government organizations (Regional Water Company, Agriculture Organization, and Justice Organization). Finally, the most probable states of equilibrium in the game results were identified.Results and DiscussionIn the discussion concerning equilibrium points, it is crucial to consider that for resolving the dispute and the proposed solution, we need to examine not only the stability of these points but also the state's priority from the perspective of stakeholders. Based on the discussions and the output results of the conflict model using the GMCR+ model, the optimal response and conflict resolution can be found in scenario 12. This scenario holds a high priority for three key players: the Agricultural Organization, the Regional Water Company, and the Justice Department. However, it doesn't share the same level of priority with the Profiteering Farmers. The reason for this divergence lies in the preference for personal gain and profit pursuit over the broader interests of the entire catchment area.ConclusionIn recent years, despite the imposed restrictions, the Urmia Lake Basin has witnessed a notable increase in the cultivation of water-intensive crops. This shift has transformed arid lands into irrigated ones and altered agricultural areas into residential zones. According to the principles of the tax evasion game, when land development carries no moral or financial consequences for profit-driven farmers, and they are aware that regulatory institutions will not commit excessive resources to prevent and effectively combat the expansion of illegal farmlands, Profiteering Farmers will consistently engage in unauthorized development under any conflict scenario. In light of the revenue potential of this situation and the opportunity to enhance one's social standing, Profiteering Farmers will persist in unauthorized development regardless of the prevailing conflict circumstances. The findings underscore the critical role of the Regional Water Company and the Agricultural Organization. These entities must proactively employ their legal capacities to impede and deter the expansion of agricultural lands. Additionally, the Justice Organization assumes primary responsibility as a crime prevention factor, while its secondary role as a judicial enforcer within this conflict situation appears fitting. Therefore, all situations are stable for Profiteering Farmers. It seems that creating a platform and conditions in which Profiteering Farmers do not develop agricultural land themselves or do not develop land due to the protection of government institutions, can be very thoughtful and effective

Leveraging artificial intelligence in neurosurgery—unveiling ChatGPT for neurosurgical discharge summaries and operative reports

Purpose Chat generative pre-trained transformer (GPT) is a novel large pre-trained natural language processing software that can enable scientific writing amongst a litany of other features. Given this, there is a growing interest in exploring the use of ChatGPT models as a modality to facilitate/assist in the provision of clinical care. Methods We investigated the time taken for the composition of neurosurgical discharge summaries and operative reports at a major University hospital. In so doing, we compared currently employed speech recognition software (i.e., SpeaKING) vs novel ChatGPT for three distinct neurosurgical diseases: chronic subdural hematoma, spinal decompression, and craniotomy. Furthermore, factual correctness was analyzed for the abovementioned diseases. Results The composition of neurosurgical discharge summaries and operative reports with the assistance of ChatGPT leads to a statistically significant time reduction across all three diseases/report types: p < 0.001 for chronic subdural hematoma, p < 0.001 for decompression of spinal stenosis, and p < 0.001 for craniotomy and tumor resection. However, despite a high degree of factual correctness, the preparation of a surgical report for craniotomy proved to be significantly lower ( p = 0.002). Conclusion ChatGPT assisted in the writing of discharge summaries and operative reports as evidenced by an impressive reduction in time spent as compared to standard speech recognition software. While promising, the optimal use cases and ethics of AI-generated medical writing remain to be fully elucidated and must be further explored in future studies