THE 2003 SUPERMARKET PANEL ANNUAL REPORT

Executive Summary The Food Industry Center established the Supermarket Panel in 1998 as the basis for an ongoing study of the supermarket industry. Since 2000 the core of the Panel has been a random sample of stores drawn from the approximately 32,000 supermarkets in the U.S. that accept food stamps. The purpose of collecting data on supermarket operations and performance is to: Provide timely, useful information for the industry through benchmark reports and annual summaries, trends on key indices of technology adoption, competitive positions and performance. Be a ready source of data for research on current and emerging issues - to be able to track the changes in operation and its impacts on performance over time. This report presents findings from the 2003 Supermarket Panel, and provides an overview of findings from the past four years. The 2003 Panel includes 391 stores that are a representative cross-section of the supermarket industry. The Panel tries to follow the same stores over time. Of the 391 stores, 268 were in the Panel in 2002. Nine percent of the stores have been in the Panel all four years. At least one store from every state is in the Panel. New in 2003 The Panel was offered over the Internet. Forty-seven percent responded on-line. An index on variety offering was created. Questions about offering irradiated fresh ground beef are included (with a follow up study). Supply Chain Technology Practices The Supply Chain Score measures the extent to which stores have adopted computerized methods of communicating with suppliers, handling inventory management, ordering, invoicing, and analyzing consumer purchases. The average score has almost doubled in four years. Stores in groups (chains) with more than 750 stores and/or supercenter formats have adopted supply chain practices most intensively. Internet/Intranet is used by at least two-thirds of all stores; over ninety percent of stores in groups with more than 50 stores use this technology. Vendor managed inventory has been adopted by only 42 percent of stores in the biggest store groups with much lower rates of adoption in smaller store groups. A higher Supply Chain Score benefited significantly higher sales per labor hour. Service and Variety Scores About eighty percent of stores in all size groups offer bagging and custom meat cutting. Variety pays off in better performance for five out of eight measures. Variety helps to grow annual percentage sales. Supercenters/Top Stores/Unions Supercenters have significantly higher sales per labor hour and per transaction. They have lower sales growth. Fifty-three percent of supermarkets face supercenter competition. They have somewhat higher sales per square foot of selling area and higher annual sales growth than stores that do not face supercenter competition. Eleven percent of stores in the 2003 Panel qualified as "top stores." They had above the median levels for each of three performance measures: weekly sales per square foot, sales per labor hour, and annual percentage sales growth. Top stores are more likely to have a unionized labor force, be a price and variety leader, and be wholesaler supplied. One-third of 2003 Panel stores have unionized labor. These stores have more productive labor with significantly higher sales per labor hour. Statistically Significant Drivers of Performance Over Time The descriptive profile and analysis of the Panel provide useful insights on the structure of the supermarket industry and factors associated with strong performance. However, statistical regression analysis identifies whether a variable is significantly correlated with a performance measure holding all else constant. This section presents findings from a multivariate regression analysis of five key performance measures. These regression analyses are summarized on the table below. If a characteristic is listed on the table it was a significant correlate in at least three out of the past four years. For example, in the last row, the only variable that was consistently significant for increasing annual percentage sales growth is being in an area with higher household incomes. Having a warehouse format decreased sales growth and three other factors were significant in at least three years but alternated with positive and negative effects.Industrial Organization, Marketing,

Simple models for the heat flux from the Atlantic meridional overturning cell to the atmosphere

It has been suggested that a slowdown of the Atlantic meridional overturning cell (AMOC) would cause the Northern Hemisphere to cool by a few degrees. We use a sequence of simple analytical models to show that due to the nonlinearity of the system, the simplified heat flux from the modeled AMOC to the atmosphere above is so robust that even changes of as much as 50% in the present AMOC transport are not enough to significantly change the temperature of the outgoing warmed atmosphere (i.e., the fraction of the atmosphere warmed by the AMOC). Our most realistic model (which is still a far cry from reality) involves a warm ocean losing heat to an otherwise motionless and colder atmosphere. As a result, the compressible atmosphere convects, and the generated airflow ultimately penetrates horizontally into the surrounding air. The behavior of the system is attributable to four key aspects of the underlying physical processes: (1) convective atmospheric transport increases by warming the atmosphere, (2) the ocean is warmer than the atmosphere, (3) the surface heat flux is usually proportional to the temperature difference between the ocean and the atmosphere, and (4) the specific heat capacity of water is much larger than that of the air. Taken together, these properties of the system lead to the existence of a dynamic “asymptotic” state, a modeled regime, in which even significant changes in the AMOC transport have almost no effect on the ocean-atmosphere heat flux and the resulting outgoing atmospheric temperature. In the hypothetical limit of an infinitely large specific heat capacity of water, Cpw there is no change in either the atmospheric transport or the temperatures of the ocean and the atmosphere, regardless of how large the reduction in the AMOC transport is. Although our models may be too simple to allow for a direct application to the ocean and atmosphere, they do shed light on the processes in question

Shape-memory properties of magnetically active triple-shape nanocomposites based on a grafted polymer network with two crystallizable switching segments

Thermo-sensitive shape-memory polymers (SMP), which are capable of memorizing two or more different shapes, have generated significant research and technological interest. A triple-shape effect (TSE) of SMP can be activated e.g. by increasing the environmental temperature (Tenv), whereby two switching temperatures (Tsw) have to be exceeded to enable the subsequent shape changes from shape (A) to shape (B) and finally the original shape (C). In this work, we explored the thermally and magnetically initiated shape-memory properties of triple-shape nanocomposites with various compositions and particle contents using different shape-memory creation procedures (SMCP). The nanocomposites were prepared by the incorporation of magnetite nanoparticles into a multiphase polymer network matrix with grafted polymer network architecture containing crystallizable poly(ethylene glycol) (PEG) side chains and poly(ε-caprolactone) (PCL) crosslinks named CLEGC. Excellent triple-shape properties were achieved for nanocomposites with high PEG weight fraction when two-step programming procedures were applied. In contrast, single-step programming resulted in dual-shape properties for all investigated materials as here the temporary shape (A) was predominantly fixed by PCL crystallites

Rhinacanthus nasutus Extracts Prevent Glutamate and Amyloid-β Neurotoxicity in HT-22 Mouse Hippocampal Cells: Possible Active Compounds Include Lupeol, Stigmasterol and β-Sitosterol

The Herb Rhinacanthus nasutus (L.) Kurz, which is native to Thailand and Southeast Asia, has become known for its antioxidant properties. Neuronal loss in a number of diseases including Alzheimer’s disease is thought to result, in part, from oxidative stress. Glutamate causes cell death in the mouse hippocampal cell line, HT-22, by unbalancing redox homeostasis, brought about by a reduction in glutathione levels, and amyloid-β has been shown to induce reactive oxygen species (ROS) production. Here in, we show that ethanol extracts of R. nasutus leaf and root are capable of dose dependently attenuating the neuron cell death caused by both glutamate and amyloid-β treatment. We used free radical scavenging assays to measure the extracts antioxidant activities and as well as quantifying phenolic, flavonoid and sterol content. Molecules found in R. nasutus, lupeol, stigmasterol and β-sitosterol are protective against glutamate toxicity

Measuring Costs and Outcomes of Tele-Intervention When Serving Families of Children who are Deaf/Hard-of-Hearing

Background: Optimal outcomes for children who are deaf/hard-of-hearing (DHH) depend on access to high quality, specialized early intervention services. Tele-intervention – the delivery of early intervention services via telehealth technology - has the potential to meet this need in a cost-effective manner.Method: Twenty-seven families of infants and toddlers with varying degrees of hearing loss participated in a randomized study, receiving their services primarily through TI or via traditional in-person home visits. Pre- and post-test measures of child outcomes, family and provider statisfaction, and costs were collected.Results: The TI group scored statistically significantly higher on the expressive language measure than the in-person group (p =.03). A measure of home visit quality revealed that the TI group scored statistically significantly better on the Parent Engagement subscale of the Home Visit Rating Scales-Adapted & Extended (HOVRS-A+; Roggman, et al., 2012). Cost savings associate with providing services via TI increased as the intensity of service delivery increased. Although most providers and families were positive about TI, there was great variability in their perceptions.Conclusions: Tele-intervention is a promising cost-effective method for delivering high quality early intervention services to families of children who are DHH

HSF1-Controlled and Age-Associated Chaperone Capacity in Neurons and Muscle Cells of C. elegans

Protein stability under changing conditions is of vital importance for the cell and under the control of a fine-tuned network of molecular chaperones. Aging and age-related neurodegenerative diseases are directly associated with enhanced protein instability. Employing C. elegans expressing GFP-tagged luciferase as a reporter for evaluation of protein stability we show that the chaperoning strategy of body wall muscle cells and neurons is significantly different and that both are differently affected by aging. Muscle cells of young worms are largely resistant to heat stress, which is directly mediated by the stress response controlled through Heat Shock Transcription Factor 1. During recovery following heat stress the ability to refold misfolded proteins is missing. Young neurons are highly susceptible to chronic heat stress, but show a high potency to refold or disaggregate proteins during subsequent recovery. The particular proteome instability in neurons results from a delayed induction of the heat shock response. In aged neurons protein stability is increased during heat stress, whereas muscle cells show enhanced protein instability due to a deteriorated heat shock response. An efficient refolding activity is absent in both aged tissues. These results provide molecular insights into the differential protein stabilization capacity in different tissues and during aging

Screening For Neurotoxic Potential Of 15 Flame Retardants Using Freshwater Planarians

Asexual freshwater planarians are an attractive invertebrate model for high-throughput neurotoxicity screening, because they possess multiple quantifiable behaviors to assess distinct neuronal functions. Planarians uniquely allow direct comparisons between developing and adult animals to distinguish developmentally selective effects from general neurotoxicity. In this study, we used our automated planarian screening platform to compare the neurotoxicity of 15 flame retardants (FRs), consisting of representative phased-out brominated (BFRs) and replacement organophosphorus FRs (OPFRs). OPFRs have emerged as a proposed safer alternative to BFRs; however, limited information is available on their health effects. We found 11 of the 15 FRs (3/6 BFRs, 7/8 OPFRs, and Firemaster 550) caused adverse effects in both adult and developing planarians with similar nominal lowest-effect-levels for BFRs and OPFRs. This suggests that replacement OPFRs are comparably neurotoxic to the phased-out compounds. BFRs were primarily systemically toxic, whereas OPFRs, except Tris(2-chloroethyl) phosphate, shared a behavioral phenotype in response to noxious heat at sublethal concentrations, indicating specific neurotoxic effects. We found this behavioral phenotype was correlated with cholinesterase inhibition, thus linking behavioral outcomes to molecular targets. By directly comparing effects on adult and developing planarians, we further found that one BFR (3,3′,5,5′-Tetrabromobisphenol A) caused a developmental selective defect. Together, these results demonstrate that our planarian screening platform yields high content data from various behavioral and morphological endpoints, allowing us to distinguish selective neurotoxic effects and effects specific to the developing nervous system. Ten of these 11 bioactive FRs were previously found to be bioactive in other models, including cell culture and alternative animal models (nematodes and zebrafish). This level of concordance across different platforms emphasizes the urgent need for further evaluation of OPFRs in mammalian systems

Biomedical Applications of Vibrational Spectroscopy: Oral Cancer Diagnostics

Vibrational spectroscopy, based on either infrared absorption or Raman scattering, has attracted increasing attention for biomedical applications. Proof of concept explorations for diagnosis of oral potentially malignant disorders and cancer are reviewed, and recent advances critically appraised. Specific examples of applications of Raman microspectroscopy for analysis of histological, cytological and saliva samples are presented for illustrative purposes, and the future prospects, ultimately for routine, chairside in vivo screening are discussed

Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis

AbstractRedox control of proteins that form disulfide bonds upon oxidative challenge is an emerging topic in the physiological and pathophysiological regulation of protein function. We have investigated the role of the neuronal calcium sensor protein visinin-like protein 1 (VILIP-1) as a novel redox sensor in a cellular system. We have found oxidative stress to trigger dimerization of VILIP-1 within a cellular environment and identified thioredoxin reductase as responsible for facilitating the remonomerization of the dimeric protein. Dimerization is modulated by calcium and not dependent on the myristoylation of VILIP-1. Furthermore, we show by site-directed mutagenesis that dimerization is exclusively mediated by Cys187. As a functional consequence, VILIP-1 dimerization modulates the sensitivity of cells to an oxidative challenge. We have investigated whether dimerization of VILIP-1 occurs in two different animal models of amyotrophic lateral sclerosis (ALS) and detected soluble VILIP-1 dimers to be significantly enriched in the spinal cord from phenotypic disease onset onwards. Moreover, VILIP-1 is part of the ALS-specific protein aggregates. We show for the first time that the C-terminus of VILIP-1, containing Cys187, might represent a novel redox-sensitive motif and that VILIP-1 dimerization and aggregation are hallmarks of ALS. This suggests that VILIP-1 dimers play a functional role in integrating the cytosolic calcium concentration and the oxidative status of the cell. Furthermore, a loss of VILIP-1 function owing to protein aggregation in ALS could be relevant in the pathophysiology of the disease