A Descriptive Study of Colorectal Cancer in Hiwa Cancer Hospital, Sulaymaniyah, Iraq

Colorectal cancer is the third most common cancer and the fourth leading cause of death from cancer worldwide. This study provides an overview of changes in sociod-demographic parameters in patients with colorectal cancer (henceforth CRC) disease in a local cancer hospital in Sulaymaniyah province of Kurdistan region of Iraq. The study included 113 patients admitted to Hiwa Cancer Hospital, Sulaymaniyah from January 2014 to December 2015. The data collection lasted for 3 weeks (from 19/12/2015 to 11/01/2016) and was obtained from the management department of Hiwa Cancer Hospital. Several socio-demographic parameters including age, gender, and smoking, as well as biochemical parameters such as liver function, renal function and blood glucose level were studied and statistically analyzed. Results have shown that the majority of CRC patients were neither current smoker nor x-smoker (P-value < 0.05). Males suffered from CRC at an earlier age compared to females (P-value < 0.05). Regarding the biochemical tests, there was no significant correlation between CRC and impaired liver function during the diagnosis process and most of the study patients had a normal liver function test on presentation. In contrast, the correlation between CRC and impaired renal function on presentation was statistically siginificant (P-value < 0.05). No significant difference was noted in the means of hematological and biochemical parameters between males and females, except for white blood cells and serum Aspartate Aminotransferase. White blood cells and total serum bilirubin showed significant differences (P-value < 0.05) between smoker and nonsmoker sub-populations. It was concluded that CRC is one of the common cancers in Sulaymaniyah province. Males develop it at an earlier age compared to females, and the impaired renal function is a significant finding on presentation

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Alzheimer’s disease (AD) is characterized by the accumulation of the tau protein in neurons, neurodegeneration and memory loss. However, the role of non-neuronal cells in this chain of events remains unclear. In the present study, we found accumulation of tau in hilar astrocytes of the dentate gyrus of individuals with AD. In mice, the overexpression of 3R tau specifically in hilar astrocytes of the dentate gyrus altered mitochondrial dynamics and function. In turn, these changes led to a reduction of adult neurogenesis, parvalbumin-expressing neurons, inhibitory synapses and hilar gamma oscillations, which were accompanied by impaired spatial memory performances. Together, these results indicate that the loss of tau homeostasis in hilar astrocytes of the dentate gyrus is sufficient to induce AD-like symptoms, through the impairment of the neuronal network. These results are important for our understanding of disease mechanisms and underline the crucial role of astrocytes in hippocampal function