Space VLBI Observations Show Tb>1012KT_b > 10^{12} K in the Quasar NRAO 530

We present here space-based VLBI observations with VSOP and a southern hemisphere ground array of the gamma-ray blazar NRAO 530 at 1.6 GHz and 5 GHz. The brightness temperature of the core at 1.6 GHz is $5 \times 10^{11}$ K. The size is near the minimum observable value in the direction of NRAO~530 due to interstellar scattering. The 5 GHz data show a single component with a brightness temperature of $\sim 3 \times 10^{12}$ K, significantly in excess of the inverse Compton limit and of the equipartition brightness temperature limit (Readhead 1994). This is strong evidence for relativistic motion in a jet requiring model-dependent Doppler boosting factors in the range 6 to 60. We show that a simple homogeneous sphere probably does not model the emission region accurately. We favor instead an inhomogeneous jet model with a Doppler boosting factor of 15.Comment: 12 pages, 2 figures. Accepted for publication in ApJ Letter

Green Bank Telescope Observations of the Eclipse of Pulsar "A" in the Double Pulsar Binary PSR J0737-3039

We report on the first Green Bank Telescope observations at 427, 820 and 1400 MHz of the newly discovered, highly inclined and relativistic double pulsar binary. We focus on the brief eclipse of PSR J0737-3039A, the faster pulsar, when it passes behind PSR J0737-3039B. We measure a frequency-averaged eclipse duration of 26.6 +/- 0.6 s, or 0.00301 +/- 0.00008 in orbital phase. The eclipse duration is found to be significantly dependent on radio frequency, with eclipses longer at lower frequencies. Specifically, eclipse duration is well fit by a linear function having slope (-4.52 +/- 0.03) x 10^{-7} orbits/MHz. We also detect significant asymmetry in the eclipse. Eclipse ingress takes 3.51 +/- 0.99 times longer than egress, independent of radio frequency. Additionally, the eclipse lasts (40 +/- 7) x 10^{-5} in orbital phase longer after conjunction, also independent of frequency. We detect significant emission from the pulsar on short time scales during eclipse in some orbits. We discuss these results in the context of a model in which the eclipsing material is a shock-heated plasma layer within the slower PSR J0737-3039B's light cylinder, where the relativistic pressure of the faster pulsar's wind confines the magnetosphere of the slower pulsar.Comment: 12 pages, 3 figure

Exercise-Induced Asthma Symptoms and Nighttime Asthma: Are They Similar to AHR?

Background. Asthma experienced during exercise and during the night is based on the presence of airway hyperresponsiveness (AHR). The aim of the present study was to examine whether AHR is a predictor of exercise-induced asthma (EIA) and nighttime symptoms. Material. We included 793 asthmatics subjects with symptoms and a positive asthma test. Results. Mean (SD) FEV1 was 93% (15), 71% had rhinitis, and 62% had atopy. Both EIA and nighttime symptoms were associated with AHR; however, when including other factors of importance in a multivariate analysis, logRDR was eliminated, whereas FEV1% pred (P < .001), smoking (P < .05), atopy (P < .001), sex (P < .001), and treatment (P < .01) were associated with having EIA while dyspnoea (P < .001), cough (P < .001), and eosinophils (P < .01) were associated with frequent night symptoms. The risk of having nighttime awakenings due to asthma was more than twofold higher among those with EIA symptoms than among those without symptoms (OR (CI95%) 2.77 (2.0–3.8) (P < .001)). In Conclusion. EIA and night symptoms are associated with AHR, but other factors of importance eliminated this close association. Night asthma is more closely associated with airway inflammation than AHR

Through thick and thin: young people's affective geographies in Brussels' public space

Young people's interaction with place is not only a cognitive process of identification but also an affective relation. There has been plenty of research on young people and/in public space but few of those studies have taken such an affective layer of analysis into account. In this paper we aim to shed some light on young people's affective geographies through the concept of ‘thick places’ as it was proposed by Edward Casey (2001), building upon ethnographic research undertaken between 2013 and 2016 in Brussels. We argue that such a concept is only useful if we consider thickness not only as a reference to ‘warm’, ‘authentic’ or ‘intimate’ places but also as a term that takes the ‘normative architecture’ of place into account. We embed this claim in a discussion of affects, atmospheres and Peter Sloterdijk's notion of nomotop.info:eu-repo/semantics/acceptedVersio

SLT-VEGF Reduces Lung Metastases, Decreases Tumor Recurrence, and Improves Survival in an Orthotopic Melanoma Model

SLT-VEGF is a recombinant cytotoxin comprised of Shiga-like toxin (SLT) subunit A fused to human vascular endothelial growth factor (VEGF). It is highly cytotoxic to tumor endothelial cells overexpressing VEGF receptor-2 (VEGFR-2/KDR/Flk1) and inhibits the growth of primary tumors in subcutaneous models of breast and prostate cancer and inhibits metastatic dissemination in orthotopic models of pancreatic cancer. We examined the efficacy of SLT-VEGF in limiting tumor growth and metastasis in an orthotopic melanoma model, using NCR athymic nude mice inoculated with highly metastatic Line IV Cl 1 cultured human melanoma cells. Twice weekly injections of SLT-VEGF were started when tumors became palpable at one week after intradermal injection of 1 × 106 cells/mouse. Despite selective depletion of VEGFR-2 overexpressing endothelial cells from the tumor vasculature, SLT-VEGF treatment did not affect tumor growth. However, after primary tumors were removed, continued SLT-VEGF treatment led to fewer tumor recurrences (p = 0.007), reduced the incidence of lung metastasis (p = 0.038), and improved survival (p = 0.002). These results suggest that SLT-VEGF is effective at the very early stages of tumor development, when selective killing of VEGFR-2 overexpressing endothelial cells can still prevent further progression. We hypothesize that SLT-VEGF could be a promising adjuvant therapy to inhibit or prevent outgrowth of metastatic foci after excision of aggressive primary melanoma lesions

New Pulsars from an Arecibo Drift Scan Search

We report the discovery of pulsars J0030+0451, J0711+0931, and J1313+0931 that were found in a search of 470 square degrees at 430 MHz using the 305m Arecibo telescope. The search has an estimated sensitivity for long period, low dispersion measure, low zenith angle, and high Galactic latitude pulsars of ~1 mJy, comparable to previous Arecibo searches. Spin and astrometric parameters for the three pulsars are presented along with polarimetry at 430 MHz. PSR J0030+0451, a nearby pulsar with a period of 4.8 ms, belongs to the less common category of isolated millisecond pulsars. We have measured significant polarization in PSR J0030+0451 over more than 50% of the period, and use these data for a detailed discussion of its magnetospheric geometry. Scintillation observations of PSR J0030+0451 provide an estimate of the plasma turbulence level along the line of sight through the local interstellar medium.Comment: 21 pages, 4 figures, Accepted for Publication in Ap