78 research outputs found
Ein neuer Genort fĂŒr eine autosomal-dominante, nichtsyndromale Schwerhörigkeit (DFNA33) liegt auf Chromosom 13q34-qte
Bei der Untersuchung einer deutschen Familie mit nichtsyndromalem Hörverlust mit frĂŒhem Beginn und autosomal-dominantem Erbgang konnten wir eine Kopplung zu bekannten DFNA-Loci ausschlieĂen und die Existenz eines neuen Locus (DFNA33) bestĂ€tigen. Mit einem nachfolgenden Genom-Scan wurde der PhĂ€notyp auf einem 6-cM-Intervall auf Chromosom 13q34-qter kartiert. FĂŒr den Marker D13S285 wurde ein maximaler 2-Punkt-Lodscore von 2,96 erreicht, der maximale Lodscore in der Multipoint-Analyse betrug 3,28 bei 124,56 cM. = By investigation of a German family pedigree with non-syndromic hearing impairment of early onset and autosomal-dominant mode of inheritance, linkage to known DFNA loci was excluded, and the existence of a new locus (DFNA33) was revealed. In a subsequent genomic scan the phenotype was mapped to a 6 cM interval on chromosome 13q34-qter. A maximum two-point lod score of 2.96 was obtained for the marker D13S285 with a maximum lod score in the multipoint analysis of 3.28 at 124.56 cM
Accurate Ritz wavelengths of parity-forbidden [Fe II], [Ti II] and [Cr II] infrared lines of astrophysical interest
With new astronomical infrared spectrographs the demands of accurate atomic
data in the infrared have increased. In this region there is a large amount of
parity-forbidden lines, which are of importance in diagnostics of low-density
astrophysical plasmas. We present improved, experimentally determined, energy
levels for the lowest even LS terms of Fe II, Ti II and Cr II, along with
accurate Ritz wavelengths for parity-forbidden transitions between and within
these terms. Spectra of Fe II, Ti II and Cr II have been produced in a hollow
cathode discharge lamp and acquired using high-resolution Fourier Transform
(FT) spectrometry. The energy levels have been determined by using observed
allowed ultraviolet transitions connecting the even terms with upper odd terms.
Ritz wavelengths of parity-forbidden lines have then been determined. Energy
levels of the four lowest Fe II terms (aD, aF, aD and
aP) have been determined, resulting in 97 different parity-forbidden
transitions with wavelengths between 0.74 and 87 micron. For Ti II the energy
levels of the two lowest terms (aF and bF) have been determined,
resulting in 24 different parity-forbidden transitions with wavelengths between
8.9 and 130 micron. Also for Cr II the energy levels of the two lowest terms
(aS and aD) have been determined, in this case resulting in 12
different parity-forbidden transitions with wavelengths between 0.80 and 140
micron.Comment: Accepted for publication in A&A, 13 pages, 6 figures, 9 table
Chloroquine and Its Derivatives Exacerbate B19V-Associated Anemia by Promoting Viral Replication
Human parvovirus B19 (B19V) is typically associated with a childhood febrile illness known as erythema infectiosum. The infection usually resolves without consequence in healthy individuals. However, in patients with immunologic and/or hematologic disorders, B19V can cause a significant pathology. The virus infects and kills red cell precursors but anemia rarely supervenes unless there is pre-existing anemia such as in children living in malaria-endemic regions. The link between B19V infection and severe anemia has, however, only been confirmed in certain malaria-endemic countries in parallel with chloroquine (CQ) usage. This raises the possibility that CQ may increase the risk of severe anemia by promoting B19V infection. To test this hypothesis, we examined the direct effect of CQ and other commonly used antimalarial drugs on B19V infection in cultured cell lines. Additionally, we examined the correlation between B19V infection, hemoglobin levels and use of CQ in children from Papua New Guinea hospitalized with severe anemia. The results suggest strongly that CQ and its derivatives aggravate B19V-associated anemia by promoting B19V replication. Hence, careful consideration should be given in choosing the drug partnering artemisinin compounds in combination antimalarial therapy in order to minimize contribution of B19V to severe anemia
Critical adsorption near edges
Symmetry breaking surface fields give rise to nontrivial and long-ranged
order parameter profiles for critical systems such as fluids, alloys or magnets
confined to wedges. We discuss the properties of the corresponding universal
scaling functions of the order parameter profile and the two-point correlation
function and determine the critical exponents eta_parallel and
eta_perpendicular for the so-called normal transition.Comment: 22 pages, 5 figures, accepted for publication in PR
Wetting films on chemically heterogeneous substrates
Based on a microscopic density functional theory we investigate the
morphology of thin liquidlike wetting films adsorbed on substrates endowed with
well-defined chemical heterogeneities. As paradigmatic cases we focus on a
single chemical step and on a single stripe. In view of applications in
microfluidics the accuracy of guiding liquids by chemical microchannels is
discussed. Finally we give a general prescription of how to investigate
theoretically the wetting properties of substrates with arbitrary chemical
structures.Comment: 56 pages, RevTeX, 20 Figure
Educators' working conditions in a day care centre on ownership of a non-profit organization
Background: Working conditions of nursery school teachers have not been scrutinized thoroughly in scientific research. Only a few studies have so far examined work-load and strain in this profession. Preferably, subjective perceptions should be corroborated by data that can be quantified more objectively and accurately. The aim of the present observational field study was to evaluate pedagogical staffs' workflow.
Methods: In 2009 eleven educators in a day care centre were observed throughout three complete workdays. A total of 250 working hours were recorded.
Results: An educators' workday lasted on average 07:46:59 h (SD = 01:01:10 h).Within this time span, an average of 02:20:46 h (30.14%, SD = 00:28:07 h) were spent on caring, 01:44:18 h on playing (22.33%, SD = 00:54:12 h), 00:49:37 h on educational work (10.62%, SD = 00:40:09), and only 00:05:38 h on individual child contact (1.21%, SD = 00:04:58 h).
Conclusion: For the first time, educators' workflow in day care centres was studied in real time. Some of the educators' self-reported problems were corroborated. The results of this study form a basis upon which further investigations can be built and measures can be developed for an overall improvement of child care
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