Intestine-Specific, Oral Delivery of Captopril/Montmorillonite: Formulation and Release Kinetics

The intercalation of captopril (CP) into the interlayers of montmorillonite (MMT) affords an intestine-selective drug delivery system that has a captopril-loading capacity of up to ca. 14 %w/w and which exhibits near-zero-order release kinetics

"Invisible burials" and fragmentation practices in Iron Age Europe:Excavations at the Monte Bernorio Necropolis (Northern Spain)

The scarcity of burial remains in large parts of Iron Age Europe, particularly in the Atlantic regions, has often led scholars to discuss the apparent “invisibility” of graves. This paper presents the results from several excavation campaigns at Monte Bernorio, one of the most important sites of the 1st millennium b.c. on the Iberian Peninsula. The fieldwork and post-excavation work carried out in the area of the necropolis have identified numerous burial pits, with complex ritual activities characterized by fragmentation and the practice of the pars pro toto. In addition, evidence for later rituals in some of the graves can be linked to ancestor worship. The results provide important insights into funerary practices in Late Iron Age Europe, leading us to rethink the very meaning of cemeteries in the study area and beyond.- Burial Traditions in Iron Age Europe - The Monte Bernorio Archaeological Zone - The 2007–2008 Necropolis Excavations - The 2015–2016 Necropolis Excavations - Post-Excavation Work and Interpretation: The Faunal and Human Remains - Structure and Chronology of Monte Bernorio Area 7 - Destruction of the Body, Commemoration in the Absence of a Corpse, and Visibility of the Mortuary Rite

Pargyline-induced increases in sensitivity to the effects of drugs on operant behavior in pigeons

Pigeons responded under a multiple fixedinterval 5-min, 30-response fixed-ratio schedule of food reinforcement. Acute pargyline doses between 10.0 and 50.0 mg/kg (i.m.), given immediately prior to the session, decreased responding. Daily administration of 50 mg/kg pargyline (24 mg/kg, every 12 h) initially decreased responding. Tolerance developed so that after 4 days of daily pargyline, responding had returned to control values. Chronic pargyline resulted in an enhanced sensitivity to the effects of d -amphetamine, ephedrine, tyramine, and morphine on schedule-controlled responding. Both d -amphetamine and pentobarbital increased fixed-interval responding at relatively low doses, while higher doses decreased responding. Daily pargyline resulted in an increased sensitivity to both the increases and decreases in response rates produced by d -amphetamine. In contrast, sensitivity to pentobarbital was not changed after daily pargyline. Ephedrine, tyramine, and morphine only decreased fixed-interval responding. Chronic pargyline resulted in an increased sensitivity to the response-rate decreasing effects of ephedrine, tyramine, and morphine. In addition to the increased sensitivity of fixed-interval responding to the effects of tyramine, the dose-effect curve for fixed-ratio responding was also a shifted to the left. Daily pargyline did not result in changes in sensitivity of fixedratio responding to the effects of the other drugs tested.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46399/1/213_2004_Article_BF00426607.pd

Examining the Conflict-Related Predictors and Spatiotemporal Dynamics of Attacks Against Humanitarian Assistance: An Algorithmic Modeling Approach

Thesis advisor: Christopher P. Salas-WrightAround the world, attacks against humanitarian aid workers pose a pervasive and intransigent threat to health and human rights, but evidence about the complex factors that predict perpetrators' behavior as well as attack outcomes remains quite limited. While previous studies have addressed several aspects of local and global trends of attacks against humanitarian assistance, more evidence is also needed to understand the dynamics of recurrent incidents, small-scale attacks, as well as patterns of events across time and space; and how the observed trends are driven by conflict-related and contextual factors. In this dissertation, we investigate the predictors and spatiotemporal dynamics of attacks against humanitarian assistance from 1997 to 2022 using publicly-available datasets from the Aid Worker Security Database (AWSD, Humanitarian Outcomes, 2022) and the Armed Conflict Dataset version 22.0 (ACD; Glaeditsch et al., 2002; Davies et al., 2022).Thesis (PhD) — Boston College, 2022.Submitted to: Boston College. Graduate School of Social Work.Discipline: Social Work

Expected utility, self-control, morality, and criminal probability

With data from random sample household surveys conducted simultaneously in major cities in Greece and in Russia, we evaluate the import of individuals' morality relative to expected utility and self-control in predicting criminal probability. In addition, we examine potential interactions among the three variables in predicting criminal propensity and compare their relative effects across the two samples. The results suggest that all three factors are important and mostly independent influences in explaining criminal probability. However, the estimated effects of morality are substantially stronger than those of either expected utility or self-control, and all three of these explanatory variables appear to be somewhat sensitive to cultural contexts. Overall, our findings confirm that morality plays a comparatively larger part in explaining conformity than is generally recognized by major contemporary theories, although the data cannot show whether morality is an element in rational decision making or represents a contrary "non-rational" element in accounting for human conduct. © 2010

The correlates of crime and deviance: Additional evidence

Comparable survey data collected simultaneously in major cities in Greece, Russia, and Ukraine indicate that the usual correlates of self-reported criminal/deviant behavior derived from research in well-studied, mostly Western societies, do not necessarily hold cross-nationally. The data confirm only two of six potential correlates of self-reported criminal/deviant behavior-age and deviant peer association. Two widely assumed correlates of criminal propensity-gender and marital status-prove to be somewhat unreliable and sensitive to these cultural contexts. Religiosity is generally negatively linked to crime/deviance in bivariate but not multivariate analyses. In bivariate analysis socioeconomic status (SES) proves to be highly sensitive to the investigated cultural contexts whereas in multivariate analysis SES is not significantly related in any consistent fashion to criminality in any of the three countries. These results show the value of cross-cultural research and suggest that effective explanation of criminal and deviant behavior may require more attention to cultural variations. © 2010 The Author(s)