29 research outputs found
Performance Analysis of Mesh-based NoC’s on Routing Algorithms
The advent of System-on-Chip (SoCs), has brought about a need to increase the scale of multi-core chip networks. Bus Based communications have proved to be limited in terms of performance and ease of scalability, the solution to both bus – based and Point-to-Point (P2P) communication systems is to use a communication infrastructure called Network-on-Chip (NoC). Performance of NoC depends on various factors such as network topology, routing strategy and switching technique and traffic patterns. In this paper, we have taken the initiative to compile together a comparative analysis of different Network on Chip infrastructures based on the classification of routing algorithm, switching technique, and traffic patterns. The goal is to show how varied combinations of the three factors perform differently based on the size of the mesh network, using NOXIM, an open source SystemC Simulator of mesh-based NoC. The analysis has shown tenable evidence highlighting the novelty of XY routing algorithm
Importance-performance analysis of UK and US bank customer perceptions of service delivery technologies
Importance-performance analysis is utilised to compare the perceptions held by bank customers regarding selected service delivery technologies (SDTs) such as automated teller machines (ATMs), telephone banking and internet banking. Bank patrons in the United Kingdom and the United States are surveyed to examine which service delivery factors they consider to be most important toward assessing the performance of SDTs offered by banking institutions. Customer views are plotted onto importance-performance grids which offer banking strategists a straightforward, graphic illustration of service factors that patrons consider to be salient and well-addressed by current installations of bank SDTs in each respective nation. The grids also offer heuristic decision guides for translating customer perceptions into strategic allocations of organisational investments toward SDT
Characteristics and Immunomodulating Functions of Adipose-Derived and Bone Marrow-Derived Mesenchymal Stem Cells Across Defined Human Leukocyte Antigen Barriers
BackgroundVascularized composite allotransplantation opens new possibilities in reconstructive transplantation such as hand or face transplants. Lifelong immunosuppression and its side-effects are the main drawbacks of this procedure. Mesenchymal stem cells (MSCs) have clinically useful immunomodulatory effects and may be able to reduce the burden of chronic immunosuppression. Herein, we assess and compare characteristics and immunomodulatory capacities of bone marrow- and adipose tissue-derived MSCs isolated from the same human individual across defined human leukocyte antigen (HLA) barriers.Materials and methodsSamples of omental (o.) adipose tissue, subcutaneous (s.c.) adipose tissue, and bone marrow aspirate from 10 human organ donors were retrieved and MSCs isolated. Cells were characterized by flow cytometry and differentiated in three lineages: adipogenic, osteogenic, and chondrogenic. In mixed lymphocyte reactions, the ability of adipose-derived mesenchymal stem cells (ASCs) and bone marrow-derived mesenchymal stem cells (BMSCs) to suppress the immune response was assessed and compared within individual donors. HLA mismatched or mitogen stimulations were analyzed in co-culture with different MSC concentrations. Supernatants were analyzed for cytokine contents.ResultsAll cell types, s.c.ASC, o.ASC, and BMSC demonstrated individual differentiation potential and cell surface markers. Immunomodulating effects were dependent on dose and cell passage. Proliferation of responder cells was most effectively suppressed by s.c.ASCs and combination with BMSC resulted in highly efficient immunomodulation. Immunomodulation was not cell contact-dependent and cells demonstrated a specific cytokine secretion.ConclusionWhen human ASCs and BMSCs are isolated from the same individual, both show effective immunomodulation across defined HLA barriers in vitro. We demonstrate a synergistic effect when cells from the same biologic system were combined. This cell contact-independent function underlines the potential of clinical systemic application of MSCs
Diet and the cancer patient
Reprint of the 1992 3rd revised editionAvailable from British Library Document Supply Centre- DSC:94/13057 / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo
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