Superspace formulation of general massive gauge theories and geometric interpretation of mass-dependent BRST symmetries

A superspace formulation is proposed for the osp(1,2)-covariant Lagrangian quantization of general massive gauge theories. The superalgebra os0(1,2) is considered as subalgebra of sl(1,2); the latter may be considered as the algebra of generators of the conformal group in a superspace with two anticommuting coordinates. The mass-dependent (anti)BRST symmetries of proper solutions of the quantum master equations in the osp(1,2)-covariant formalism are realized in that superspace as invariance under translations combined with mass-dependent special conformal transformations. The Sp(2) symmetry - in particular the ghost number conservation - and the "new ghost number" conservation are realized as invariance under symplectic rotations and dilatations, respectively. The transformations of the gauge fields - and of the full set of necessarily required (anti)ghost and auxiliary fields - under the superalgebra sl(1,2) are determined both for irreducible and first-stage reducible theories with closed gauge algebra.Comment: 35 pages, AMSTEX, precision of reference

The potent vasodilating and guanylyl cyclase activating dinitrosyl-iron(II) complex is stored in a protein-bound form in vascular tissue and is released by thiols

AbstractWe studied the biological activity, stability and interaction of dinitrosyl-iron(II)-L-cysteine with vascular tissue. Dinitrosyl-iron((II)-L-cysteine was a potent activator of purified soluble guanylyl cyclase (EC50 (nM with and 100 nM without superoxide dismutase) and relaxed noradrenaline-precontracted segments of endothelium-denuded rabbit femoral artery (EC50 10 nM superoxide dismutase). Pre-incubation (5 min; 310 K) of endothelium-denuded rabbit aortic segments with dinitrosyl-iron(II)-L-cysteine (0.036–3.6 mM) resulted in a concentration-dependent formation of a dinitrosyl-iron(II complex with protein thiol groups, as detected by ESR spectroscopy. While the complex with proteins was stable for 2 h at 310 K, dinitrosyl-iron(II)-L-cysteine in aqueous solution (30–360 μM) decomposed completely within 15 min, as indicated by disappearance of its isotropic ESR signal at gav = 2.03 (293 K). Aortic segments pre-incubated with dinitrosyl-iron(II)-L-cysteine released a labile vasodilating and guanylyl cyclase activating factor. Perfusion of these segments with N-acetyl-L-cysteine resulted in the generation of a low molecular weight dinitrosyl-iron(II)-dithiolate from the dinitrosyl-iron(II) complex with proteins, as revealed by the shape change of the ESR signal at 293 K. The low molecular weight dinitrosyl-iron(II)-dithiolate accounted to an enhanced guanylyl cyclase activation and vasodilation induced by the aortic effluent. We conclude that nitric oxide (NO) produced by, or acting on vascular cells can be stabilized and stored as a dinitrosyl-iron(II) complex with protein thiols, and can be released from cells in the form of a low molecular weight dinitrosyl-iron(II)-dithiolate by intra- and extracellular thiols

G_2 invariant 7D Euclidean super Yang-Mills theory as a higher-dimensional analogue of the 3D super-BF theory

A formulation of the N_T=1, D=8 Euclidean super Yang-Mills theory with generalized self-duality and reduced Spin(7)-invariance is given which avoids the peculiar extra constraints of Nishino and Rajpoot, hep-th/0210132. Its reduction to 7 dimensions leads to the G_2-invariant N_T=2, D=7 super Yang-Mills theory which may be regarded as a higher-dimensional analogue of the N=2, D=3 super-BF theory. When reducing further that G_2-invariant theory to 3 dimensions one gets the N_T=2 super-BF theory coupled to a spinorial hypermultiplet.Comment: 9 pages, Late

The basic cohomology of the twisted N=16, D=2 super Maxwell theory

We consider a recently proposed two-dimensional Abelian model for a Hodge theory, which is neither a Witten type nor a Schwarz type topological theory. It is argued that this model is not a good candidate for a Hodge theory since, on-shell, the BRST Laplacian vanishes. We show, that this model allows for a natural extension such that the resulting topological theory is of Witten type and can be identified with the twisted N=16, D=2 super Maxwell theory. Furthermore, the underlying basic cohomology preserves the Hodge-type structure and, on-shell, the BRST Laplacian does not vanish.Comment: 9 pages, Latex; new Section 4 showing the invariants added; 2 references and relating remarks adde

Twisted N=8, D=2 super Yang-Mills theory as example of a Hodge-type cohomological theory

It is shown that the dimensional reduction of the N_T=2, D=3 Blau-Thompson model to D=2, i.e., the novel topological twist of N=8, D=2 super Yang-Mills theory, provides an example of a Hodge-type cohomological theory. In that theory the generators of the topological shift, co-shift and gauge symmetry, together with a discrete duality operation, are completely analogous to the de Rham cohomology operators and the Hodge *-operation.Comment: 8 pages, Late

Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult

AbstractObjective: Hyperoxic cardiopulmonary bypass is widely used during cardiac operations in the adult. This management may cause oxygenation injury induced by oxygen-derived free radicals and nitric oxide. Oxidative damage may be significantly limited by maintaining a more physiologic oxygen tension strategy (normoxic cardiopulmonary bypass). Methods: During elective coronary artery bypass grafting, 40 consecutive patients underwent either hyperoxic (oxygen tension = 400 mm Hg) or normoxic (oxygen tension = 140 mm Hg) cardiopulmonary bypass. At the beginning and the end of bypass this study assessed polymorphonuclear leukocyte elastase, nitrate, creatine kinase, and lactic dehydrogenase, antioxidant levels, and malondialdehyde in coronary sinus blood. Cardiac index was measured before and after cardiopulmonary bypass. Results: There was no difference between groups with regard to age, sex, severity of disease, ejection fraction, number of grafts, duration of cardiopulmonary bypass, or ischemic time. Hyperoxic bypass resulted in higher levels of polymorphonuclear leukocyte elastase (377 ± 34 vs 171 ± 32 ng/ml, p = 0.0001), creatine kinase 672 ± 130 vs 293 ± 21 U/L, p = 0.002), lactic dehydrogenase (553 ± 48 vs 301 ± 12 U/L, p = 0.003), antioxidants (1.97 ± 0.10 vs 1.41 ± 0.11 mmol/L, p = 0.01), malondialdehyde (1.36 ± 0.1 μmol/L, p = 0.005), and nitrate (19.3 ± 2.9 vs 10.1 ± 2.1 μmol/L, p = 0.002), as well as reduction in lung vital capacity (66% ± 2% vs 81% ± 1%, p = 0.01) and forced 1-second expiratory volume (63% ± 10% vs 93% ± 4%, p = 0.005) compared with normoxic management. Cardiac index after cardiopulmonary bypass at low filling pressure was similar between groups (3.1 ± 0.2 vs 3.3 ± 0.3 L/min per square meter). [Data are mean ± standard error (analysis of variance), with p values compared with an oxygen tension of 400 mm Hg. Conclusions: Hyperoxic cardiopulmonary bypass during cardiac operations in adults results in oxidative myocardial damage related to oxygen-derived free radicals and nitric oxide. These adverse effects can be markedly limited by reduced oxygen tension management. The concept of normoxic cardiopulmonary bypass may be applied to surgical advantage during cardiac operations. (J Thorac Cardiovasc Surg 1998;116:327-34