281 research outputs found
Superspace formulation of general massive gauge theories and geometric interpretation of mass-dependent BRST symmetries
A superspace formulation is proposed for the osp(1,2)-covariant Lagrangian
quantization of general massive gauge theories. The superalgebra os0(1,2) is
considered as subalgebra of sl(1,2); the latter may be considered as the
algebra of generators of the conformal group in a superspace with two
anticommuting coordinates. The mass-dependent (anti)BRST symmetries of proper
solutions of the quantum master equations in the osp(1,2)-covariant formalism
are realized in that superspace as invariance under translations combined with
mass-dependent special conformal transformations. The Sp(2) symmetry - in
particular the ghost number conservation - and the "new ghost number"
conservation are realized as invariance under symplectic rotations and
dilatations, respectively. The transformations of the gauge fields - and of the
full set of necessarily required (anti)ghost and auxiliary fields - under the
superalgebra sl(1,2) are determined both for irreducible and first-stage
reducible theories with closed gauge algebra.Comment: 35 pages, AMSTEX, precision of reference
The potent vasodilating and guanylyl cyclase activating dinitrosyl-iron(II) complex is stored in a protein-bound form in vascular tissue and is released by thiols
AbstractWe studied the biological activity, stability and interaction of dinitrosyl-iron(II)-L-cysteine with vascular tissue. Dinitrosyl-iron((II)-L-cysteine was a potent activator of purified soluble guanylyl cyclase (EC50 (nM with and 100 nM without superoxide dismutase) and relaxed noradrenaline-precontracted segments of endothelium-denuded rabbit femoral artery (EC50 10 nM superoxide dismutase). Pre-incubation (5 min; 310 K) of endothelium-denuded rabbit aortic segments with dinitrosyl-iron(II)-L-cysteine (0.036–3.6 mM) resulted in a concentration-dependent formation of a dinitrosyl-iron(II complex with protein thiol groups, as detected by ESR spectroscopy. While the complex with proteins was stable for 2 h at 310 K, dinitrosyl-iron(II)-L-cysteine in aqueous solution (30–360 μM) decomposed completely within 15 min, as indicated by disappearance of its isotropic ESR signal at gav = 2.03 (293 K). Aortic segments pre-incubated with dinitrosyl-iron(II)-L-cysteine released a labile vasodilating and guanylyl cyclase activating factor. Perfusion of these segments with N-acetyl-L-cysteine resulted in the generation of a low molecular weight dinitrosyl-iron(II)-dithiolate from the dinitrosyl-iron(II) complex with proteins, as revealed by the shape change of the ESR signal at 293 K. The low molecular weight dinitrosyl-iron(II)-dithiolate accounted to an enhanced guanylyl cyclase activation and vasodilation induced by the aortic effluent. We conclude that nitric oxide (NO) produced by, or acting on vascular cells can be stabilized and stored as a dinitrosyl-iron(II) complex with protein thiols, and can be released from cells in the form of a low molecular weight dinitrosyl-iron(II)-dithiolate by intra- and extracellular thiols
G_2 invariant 7D Euclidean super Yang-Mills theory as a higher-dimensional analogue of the 3D super-BF theory
A formulation of the N_T=1, D=8 Euclidean super Yang-Mills theory with
generalized self-duality and reduced Spin(7)-invariance is given which avoids
the peculiar extra constraints of Nishino and Rajpoot, hep-th/0210132. Its
reduction to 7 dimensions leads to the G_2-invariant N_T=2, D=7 super
Yang-Mills theory which may be regarded as a higher-dimensional analogue of the
N=2, D=3 super-BF theory. When reducing further that G_2-invariant theory to 3
dimensions one gets the N_T=2 super-BF theory coupled to a spinorial
hypermultiplet.Comment: 9 pages, Late
The basic cohomology of the twisted N=16, D=2 super Maxwell theory
We consider a recently proposed two-dimensional Abelian model for a Hodge
theory, which is neither a Witten type nor a Schwarz type topological theory.
It is argued that this model is not a good candidate for a Hodge theory since,
on-shell, the BRST Laplacian vanishes. We show, that this model allows for a
natural extension such that the resulting topological theory is of Witten type
and can be identified with the twisted N=16, D=2 super Maxwell theory.
Furthermore, the underlying basic cohomology preserves the Hodge-type structure
and, on-shell, the BRST Laplacian does not vanish.Comment: 9 pages, Latex; new Section 4 showing the invariants added; 2
references and relating remarks adde
Twisted N=8, D=2 super Yang-Mills theory as example of a Hodge-type cohomological theory
It is shown that the dimensional reduction of the N_T=2, D=3 Blau-Thompson
model to D=2, i.e., the novel topological twist of N=8, D=2 super Yang-Mills
theory, provides an example of a Hodge-type cohomological theory. In that
theory the generators of the topological shift, co-shift and gauge symmetry,
together with a discrete duality operation, are completely analogous to the de
Rham cohomology operators and the Hodge *-operation.Comment: 8 pages, Late
Normoxic cardiopulmonary bypass reduces oxidative myocardial damage and nitric oxide during cardiac operations in the adult
AbstractObjective: Hyperoxic cardiopulmonary bypass is widely used during cardiac operations in the adult. This management may cause oxygenation injury induced by oxygen-derived free radicals and nitric oxide. Oxidative damage may be significantly limited by maintaining a more physiologic oxygen tension strategy (normoxic cardiopulmonary bypass). Methods: During elective coronary artery bypass grafting, 40 consecutive patients underwent either hyperoxic (oxygen tension = 400 mm Hg) or normoxic (oxygen tension = 140 mm Hg) cardiopulmonary bypass. At the beginning and the end of bypass this study assessed polymorphonuclear leukocyte elastase, nitrate, creatine kinase, and lactic dehydrogenase, antioxidant levels, and malondialdehyde in coronary sinus blood. Cardiac index was measured before and after cardiopulmonary bypass. Results: There was no difference between groups with regard to age, sex, severity of disease, ejection fraction, number of grafts, duration of cardiopulmonary bypass, or ischemic time. Hyperoxic bypass resulted in higher levels of polymorphonuclear leukocyte elastase (377 ± 34 vs 171 ± 32 ng/ml, p = 0.0001), creatine kinase 672 ± 130 vs 293 ± 21 U/L, p = 0.002), lactic dehydrogenase (553 ± 48 vs 301 ± 12 U/L, p = 0.003), antioxidants (1.97 ± 0.10 vs 1.41 ± 0.11 mmol/L, p = 0.01), malondialdehyde (1.36 ± 0.1 μmol/L, p = 0.005), and nitrate (19.3 ± 2.9 vs 10.1 ± 2.1 μmol/L, p = 0.002), as well as reduction in lung vital capacity (66% ± 2% vs 81% ± 1%, p = 0.01) and forced 1-second expiratory volume (63% ± 10% vs 93% ± 4%, p = 0.005) compared with normoxic management. Cardiac index after cardiopulmonary bypass at low filling pressure was similar between groups (3.1 ± 0.2 vs 3.3 ± 0.3 L/min per square meter). [Data are mean ± standard error (analysis of variance), with p values compared with an oxygen tension of 400 mm Hg. Conclusions: Hyperoxic cardiopulmonary bypass during cardiac operations in adults results in oxidative myocardial damage related to oxygen-derived free radicals and nitric oxide. These adverse effects can be markedly limited by reduced oxygen tension management. The concept of normoxic cardiopulmonary bypass may be applied to surgical advantage during cardiac operations. (J Thorac Cardiovasc Surg 1998;116:327-34
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