Calcareous nannofossil and foraminifer biostratigraphy of the Campanian–Maastrichtian chalk of the Femern Bælt (Denmark–Germany).

A new study based on calcareous nannofossil and benthic and planktonic foraminifer biostratigraphy is presented for the upper Campanian – Maastrichtian chalk of the Femern Bælt (Denmark and Germany; Fig.1). The results are consistent with recent studies of the Danish chalk for this interval, allowing correlation across the Danish Basin and forming the basis for correlation further afield within the Boreal Realm. Numerous studies have been carried out recently on the upper Campanian – Maastrichtian chalk of the Danish Basin, covering aspects such as sedimentology, depositional environment, macrofossil biostratigraphy, carbon isotope stratigraphy as well as nannofossil and dinoflagellate biostratigraphy. However, very few published studies on foraminifers exist across this interval in this area. The 09.A.006, 09.A.007 and 09.A.008 boreholes (Fig. 2) were drilled in 2009 in preparation for construction of a fixed link across the Femern Bælt, which will connect Denmark to Germany (Rambøll Arup JV 2011). The boreholes penetrated glacial till, Paleocene– Eocene clay and chalk (Sheldon et al. 2012). Here, for the first time, the Boreal foraminifer biostratigraphy of the late Campanian – Maastrichtian interval is investigated and presented alongside nannofossil biostratigraphy

On the dust properties of high-redshift molecular clouds and the connection to the 2175 Å extinction bump

We present a study of the extinction and depletion-derived dust properties of gamma-ray burst (GRB) absorbers at $1<z<3$ showing the presence of neutral carbon (\ion{C}{I}). By modelling their parametric extinction laws, we discover a broad range of dust models characterizing the GRB \ion{C}{I} absorption systems. In addition to the already well-established correlation between the amount of \ion{C}{I} and visual extinction, $A_V$, we also observe a correlation with the total-to-selective reddening, $R_V$. All three quantities are also found to be connected to the presence and strength of the 2175\,{\AA} dust extinction feature. While the amount of \ion{C}{I} is found to be correlated with the SED-derived dust properties, we do not find any evidence for a connection with the depletion-derived dust content as measured from [Zn/Fe] and $N$(Fe)$_{\rm dust}$. To reconcile this, we discuss a scenario where the observed extinction is dominated by the composition of dust particles confined in the molecular gas-phase of the ISM. We argue that since the depletion level trace non-carbonaceous dust in the ISM, the observed extinction in GRB \ion{C}{I} absorbers is primarily produced by carbon-rich dust in the molecular cloud and is therefore only observable in the extinction curves and not in the depletion patterns. This also indicates that the 2175\,{\AA} dust extinction feature is caused by dust and molecules in the cold and molecular gas-phase. This scenario provides a possible resolution to the discrepancy between the depletion- and SED-derived amounts of dust in high-$z$ absorbers.Comment: 10 pages, 5 Figs. + Appendix. Accepted in MNRA

Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)

BACKGROUND: Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control. METHODS: Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights. FINDINGS: 5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease. INTERPRETATION: International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems

Determination of Nitrogen and Sulphur Mineralization in Batch and Semi-Continuous Anaerobic Digestion Using an Artificial Fiber Bag Technique

In the biogas industry, feedstock plans are used to estimate methane production and nutrient content in the digestate, however, these predictions do not consider the mineralized nitrogen fraction of the feedstock, which is useful when determining the quality of the digestate. In this study, the artificial fiber bag technique, which is commonly used to study feedstock degradation in ruminants, was implemented in anaerobic digestion to quantify mineralization of N and S. The artificial fiber bags were used to enclose substrates but with access to inoculum because of small pores in the bags, thereby enabling digestion. The content of the bags was analyzed before and after digestion to quantify residual mass as well as N and S concentration in the substrate. The method was validated through batch anaerobic digestion of a single substrate with and without bags, where the bags showed little influence on methane production and degradation. Semi-continuous anaerobic digestion experiments showed higher substrate degradation and higher N and S release at thermophilic conditions using four different types of feedstocks and proved useful for solid feedstocks but less so for semi-solid feedstock. For N, most of the mineralization occurred during the first 15 days over a trial of 30 days