Preoperative Acute Normovolaemic Hemodilution (ANH) in combination with Hypotensive Epidural Anaesthesia (HEA) during knee arthroplasty surgery. No effect on transfusion rate. A randomized controlled trial [ISRCTN87597684]

BACKGROUND: Hypotensive epidural anaesthesia (HEA) combines a high epidural anaesthesia, performing a sympathetic blockade, with low-dose iv-infusion of epinephrine to stabilize circulation in the conscious patient. Mean artery blood pressure is reduced to 45–50 mmHg and hereby a reduced blood loss. In this study we have combined HEA with preoperative acute normovolaemic hemodilution (ANH) in attempt to further reduce the blood loss and need for blood transfusion in total knee arthroplasty surgery (TKR). METHODS: Twenty-eight patients scheduled for TKR are randomised to ANH or no hemodilution (non-ANH). Both groups are anaesthetized with HEA. ANH is established with predonation of 20 % of the total blood volume, and replacement with equal volume of HAES 6 %. Blood re-transfusion is completed within 6 h. RESULTS: A mean of 877 ml blood was predonated (19.7 % of the total blood volume). Blood loss was, except from the intraoperative loss, significantly higher in ANH group. The total loss was 1306 mL (ANH) vs. 1026 mL (non-ANH), p < 0.05. Except from the first hour postoperatively, hematocrit was identical in between groups postoperatively. The amount of blood transfusion was identical 386 ml (ANH) vs. 343 ml (non-ANH) (ns). 50 % went through surgery without receiving blood (ANH) vs. 58 % (non-ANH). No renal, neurological or cardiopulmonary complications were registered. CONCLUSIONS: These data suggest no benefits in combining HEA and ANH in TKR surgery. Probably because of the reduced viscosity of the blood after ANH, there is an increased postoperative blood loss. The need for homologous blood transfusion was identical

Consensus report on 25 years of searches for damped Lyα\alpha galaxies in emission: Confirming their metallicity-luminosity relation at z≳2z \gtrsim 2

Starting from a summary of detection statistics of our recent X-shooter campaign, we review the major surveys, both space and ground based, for emission counterparts of high-redshift damped Ly$\alpha$ absorbers (DLAs) carried out since the first detection 25 years ago. We show that the detection rates of all surveys are precisely reproduced by a simple model in which the metallicity and luminosity of the galaxy associated to the DLA follow a relation of the form, ${\rm M_{UV}} = -5 \times \left(\,[{\rm M/H}] + 0.3\, \right) - 20.8$, and the DLA cross-section follows a relation of the form $\sigma_{DLA} \propto L^{0.8}$. Specifically, our spectroscopic campaign consists of 11 DLAs preselected based on their equivalent width of SiII $\lambda1526$ to have a metallicity higher than [Si/H] > -1. The targets have been observed with the X-shooter spectrograph at the Very Large Telescope to search for emission lines around the quasars. We observe a high detection rate of 64% (7/11), significantly higher than the typical $\sim$10% for random, HI-selected DLA samples. We use the aforementioned model, to simulate the results of our survey together with a range of previous surveys: spectral stacking, direct imaging (using the `double DLA' technique), long-slit spectroscopy, and integral field spectroscopy. Based on our model results, we are able to reconcile all results. Some tension is observed between model and data when looking at predictions of Ly$\alpha$ emission for individual targets. However, the object to object variations are most likely a result of the significant scatter in the underlying scaling relations as well as uncertainties in the amount of dust which affects the emission.Comment: 25 pages (7 of which in appendix), accepted for publication in MNRA

The Optically Unbiased GRB Host (TOUGH) survey. IV. Lyman-alpha emitters

We report the results of a spectroscopic search for Lyman-alpha emission from gamma-ray burst host galaxies. Based on the well-defined TOUGH sample of 69 X-ray selected Swift GRBs, we have targeted the hosts of a subsample of 20 GRBs known from afterglow spectroscopy to be in the redshift range 1.8-4.5. We detect Lya emission from 7 out of the 20 hosts, with the typical limiting 3sigma line flux being 8E-18 erg/cm2/s, corresponding to a Lya luminosity of 6E41 erg/s at z=3. The Lya luminosities for the 7 hosts in which we detect Lya emission are in the range (0.6-2.3)E42 erg/s corresponding to star-formation rates of 0.6-2.1 Msun/yr (not corrected for extinction). The rest-frame Lya equivalent widths (EWs) for the 7 hosts are in the range 9-40A. For 6 of the 13 hosts for which Lya is not detected we place fairly strong 3sigma upper limits on the EW (<20A), while for others the EW is either unconstrained or has a less constraining upper limit. We find that the distribution of Lya EWs is inconsistent with being drawn from the Lya EW distribution of bright Lyman break galaxies at the 98.3% level, in the sense that the TOUGH hosts on average have larger EWs than bright LBGs. We can exclude an early indication, based on a smaller, heterogeneous sample of pre-Swift GRB hosts, that all GRB hosts are Lya emitters. We find that the TOUGH hosts on average have lower EWs than the pre-Swift GRB hosts, but the two samples are only inconsistent at the 92% level. The velocity centroid of the Lya line is redshifted by 200-700 km/s with respect to the systemic velocity, similar to what is seen for LBGs, possibly indicating star-formation driven outflows from the host galaxies. There seems to be a trend between the Lya EW and the optical to X-ray spectral index of the afterglow (beta_OX), hinting that dust plays a role in the observed strength and even presence of Lya emission. [ABRIDGED]Comment: ApJ accepted (v2: minor changes in the Subject headings and reference list

On the mass-metallicity relation, velocity dispersion and gravitational well depth of GRB host galaxies

We analyze a sample of 16 absorption systems intrinsic to long duration GRB host galaxies at $z \gtrsim 2$ for which the metallicities are known. We compare the relation between the metallicity and cold gas velocity width for this sample to that of the QSO-DLAs, and find complete agreement. We then compare the redshift evolution of the mass-metallicity relation of our sample to that of QSO-DLAs and find that also GRB hosts favour a late onset of this evolution, around a redshift of $\approx 2.6$. We compute predicted stellar masses for the GRB host galaxies using the prescription determined from QSO-DLA samples and compare the measured stellar masses for the four hosts where stellar masses have been determined from SED fits. We find excellent agreement and conclude that, on basis of all available data and tests, long duration GRB-DLA hosts and intervening QSO-DLAs are consistent with being drawn from the same underlying population. GRB host galaxies and QSO-DLAs are found to have different impact parameter distributions and we briefly discuss how this may affect statistical samples. The impact parameter distribution has two effects. First any metallicity gradient will shift the measured metallicity away from the metallicity in the centre of the galaxy, second the path of the sightline through different parts of the potential well of the dark matter halo will cause different velocity fields to be sampled. We report evidence suggesting that this second effect may have been detected.Comment: 11 pages, 6 figures, 6 tables. Accepted for publication in MNRAS Main Journal. For the definitive version visit http://mnras.oxfordjournals.org

The evolution of field early-type galaxies to z~0.7

We have measured the Fundamental Plane (FP) parameters for a sample of 30 field early-type galaxies (E/S0) in the redshift range 0.1<z<0.66. We find that: i) the FP is defined and tight out to the highest redshift bin; ii) the intercept \gamma evolves as d\gamma/dz=0.58+0.09-0.13 (for \Omega=0.3, \Omega_{\Lambda}=0.7), or, in terms of average effective mass to light ratio, as d\log(M/L_B)/dz=-0.72+0.11-0.16, i.e. faster than is observed for cluster E/S0 -0.49+-0.05. In addition, we detect [OII] emission >5\AA in 22% of an enlarged sample of 42 massive E/S0 in the range 0.1<z<0.73, in contrast with the quiescent population observed in clusters at similar z. We interpret these findings as evidence that a significant fraction of massive field E/S0 experiences secondary episodes of star-formation at z<1.Comment: ApJ Letters, in pres

The high A_V Quasar Survey: A z=2.027 metal-rich damped Lyman-alpha absorber towards a red quasar at z=3.21

To fully exploit the potential of quasars as probes of cosmic chemical evolution and the internal gas dynamics of galaxies it is important to understand the selection effects behind the quasar samples and in particular if the selection criteria exclude foreground galaxies with certain properties (most importantly a high dust content). Here we present spectroscopic follow-up from the 10.4-m GTC telescope of a dust-reddened quasar, eHAQ0111+0641, from the extended High A_V Quasar (HAQ) survey. We find that the z=3.21 quasar has a foreground Damped Lyman-alpha Absorber (DLA) at z=2.027 along the line of sight. The DLA has very strong metal lines due to a moderately high metallicity (with an inferred lower limit of 25% of the solar metallicity), but a very large gas column density along the line-of-sight in its host galaxy. This discovery is further evidence that there is a dust bias affecting the census of metals, caused by the combined effect of dust obscuration and reddening, in existing samples of z>2 DLAs. The case of eHAQ0111+0641 illustrates that dust bias is not only caused by dust obscuration, but also dust reddening.Comment: 7 pages, 4 figures. Accepted for publication in A&A. A few typos have been correcte

Extinction curve template for intrinsically reddened quasars

We analyze the near-infrared to UV data of 16 quasars with redshifts ranging from 0.71 $<$ $z$ $<$ 2.13 to investigate dust extinction properties. The sample presented in this work is obtained from the High $A_V$ Quasar (HAQ) survey. The quasar candidates were selected from the Sloan Digital Sky Survey (SDSS) and the UKIRT Infrared Deep Sky Survey (UKIDSS), and follow-up spectroscopy was carried out at the Nordic Optical Telescope (NOT) and the New Technology Telescope (NTT). To study dust extinction curves intrinsic to the quasars, from the HAQ survey we selected 16 cases where the Small Magellanic Cloud (SMC) law could not provide a good solution to the spectral energy distributions (SEDs). We derived the extinction curves using Fitzpatrick & Massa 1986 (FM) law by comparing the observed SEDs to the combined quasar template from Vanden Berk et al. 2001 and Glikman et al. 2006. The derived extinction, $A_V$, ranges from 0.2-1.0 mag. All the individual extinction curves of our quasars are steeper ($R_V=2.2$-2.7) than that of the SMC, with a weighted mean value of $R_V=2.4$. We derive an `average quasar extinction curve' for our sample by fitting SEDs simultaneously by using the weighted mean values of the FM law parameters and a varying $R_V$. The entire sample is well fit with a single best-fit value of $R_V=2.2\pm0.2$. The `average quasar extinction curve' deviates from the steepest Milky Way and SMC extinction curves at a confidence level $\gtrsim95\%$. Such steep extinction curves suggest a significant population of silicates to produce small dust grains. Moreover, another possibility could be that the large dust grains may have been destroyed by the activity of the nearby active galactic nuclei (AGN), resulting in steep extinction curves.Comment: 8 pages, 4 figures, 1 tabl