Intensive Chemotherapy with Autologous Peripheral Blood Stem Cell Transplantation During a 10-Year Period in 64 Patients with Germ Cell Tumor

AbstractDespite gratifying cure rates in germ cell tumors, conventional-dose chemotherapy achieves long-term remissions in less than 50% of patients at high risk. High-dose chemotherapy followed by autologous (auto) peripheral blood stem cell transplantation (PBSCT) has shown impressive remission rates in high-risk and relapsed germ cell tumors. We report on 64 consecutive patients with high- (n = 39), intermediate- (n = 18), and refractory or relapsed low- (n = 7) risk germ cell tumors who underwent auto-PBSCT between January 1993 and February 2003. PBSCTs were performed as a single (n = 40) or repeated (n = 24) transplantation using either etoposide, ifosfamide, and carboplatin (n = 80) or related protocols (paclitaxel, ifosfamide, carboplatin, etoposide [n = 7]; carboplatin, etoposide, thiotepa [n = 4]). With a median follow-up of 6 years, estimated 2- and 5-year overall survivals were 77.2% (95% confidence interval [CI] 66.7-87.7) and 73.1% (95% CI 61.7-84.5), respectively. We observed unfavorable results in those patients showing refractoriness to cisplatin (hazard ratio 20.36; 95% CI 6.64-62.47) or no response to induction chemotherapy (hazard ratio 10.67; 95% CI 1.37-83.37). Auto-PBSCT was well tolerated, showed objective antitumor activity, and achieved long-term survival in patients at high risk and with relapse. Our data suggest that auto-PBSCT can increase response rates and may improve the outcome in these patients

Exponential-Potential Scalar Field Universes I: The Bianchi I Models

We obtain a general exact solution of the Einstein field equations for the anisotropic Bianchi type I universes filled with an exponential-potential scalar field and study their dynamics. It is shown, in agreement with previous studies, that for a wide range of initial conditions the late-time behaviour of the models is that of a power-law inflating FRW universe. This property, does not hold, in contrast, when some degree of inhomogeneity is introduced, as discussed in our following paper II.Comment: 16 pages, Plain LaTeX, 1 Figure to be sent on request, to appear in Phys. Rev.

An outflow in the Seyfert ESO 362-G18 revealed by Gemini-GMOS/IFU observations

Indexación: Scopus.We present two-dimensional stellar and gaseous kinematics of the inner 0.7 × 1.2 kpc2 of the Seyfert 1.5 galaxy ESO 362-G18, derived from optical (4092-7338 Å) spectra obtained with the GMOS integral field spectrograph on the Gemini South telescope at a spatial resolution of ≈ 170 pc and spectral resolution of 36 km s-1. ESO 362-G18 is a strongly perturbed galaxy of morphological type Sa or S0/a, with a minor merger approaching along the NE direction. Previous studies have shown that the [O III] emission shows a fan-shaped extension of ≈ 10′′ to the SE. We detect the [O III] doublet, [N II] and Hα emission lines throughout our field of view. The stellar kinematics is dominated by circular motions in the galaxy plane, with a kinematic position angle of ≈ 137° and is centred approximately on the continuum peak. The gas kinematics is also dominated by rotation, with kinematic position angles ranging from 122° to 139°, projected velocity amplitudes of the order of 100 km s-1, and a mean velocity dispersion of 100 km s-1. A double-Gaussian fit to the [O III]λ5007 and Hα lines, which have the highest signal to noise ratios of the emission lines, reveal two kinematic components: (1) a component at lower radial velocities which we interpret as gas rotating in the galactic disk; and (2) a component with line of sight velocities 100-250 km s-1 higher than the systemic velocity, interpreted as originating in the outflowing gas within the AGN ionization cone. We estimate a mass outflow rate of 7.4 × 10-2 M⊙ yr-1 in the SE ionization cone (this rate doubles if we assume a biconical configuration), and a mass accretion rate on the supermassive black hole (SMBH) of 2.2 × 10-2 M⊙ yr-1. The total ionized gas mass within ∼84 pc of the nucleus is 3.3 × 105 M⊙; infall velocities of ∼34 km s-1 in this gas would be required to feed both the outflow and SMBH accretion. © ESO 2018.https://www.aanda.org/articles/aa/abs/2018/06/aa31671-17/aa31671-17.htm

Search for excited τ-leptons and leptoquarks in the final state with τ-leptons and jets in pp collisions at √s = 13 TeV

A search is reported for excited τ-leptons and leptoquarks in events with two hadronically decaying τ-leptons and two or more jets. The search uses proton-proton (pp) collision data at √s = 13 TeV recorded by the ATLAS experiment during the Run 2 of the Large Hadron Collider in 2015–2018. The total integrated luminosity is 139 fb−1. The excited τ-lepton is assumed to be produced and to decay via a four-fermion contact interaction into an ordinary τ-lepton and a quark-antiquark pair. The leptoquarks are assumed to be produced in pairs via the strong interaction, and each leptoquark is assumed to couple to a charm or lighter quark and a τ-lepton. No excess over the background prediction is observed. Excited τ-leptons with masses below 2.8 TeV are excluded at 95% CL in scenarios with the contact interaction scale Λ set to 10 TeV. At the extreme limit of model validity where Λ is set equal to the excited τ-lepton mass, excited τ-leptons with masses below 4.6 TeV are excluded. Leptoquarks with masses below 1.3 TeV are excluded at 95% CL if their branching ratio to a charm quark and a τ-lepton equals 1. The analysis does not exploit flavour-tagging in the signal region

Search for magnetic monopoles and stable particles with high electric charges in √s = 13 TeV pp collisions with the ATLAS detector

We present a search for magnetic monopoles and high-electric-charge objects using LHC Run 2 √s = 13 TeV proton-proton collisions recorded by the ATLAS detector. A total integrated luminosity of 138 fb−1 was collected by a specialized trigger. No highly ionizing particle candidate was observed. Considering the Drell-Yan and photon-fusion pair production mechanisms as benchmark models, cross-section upper limits are presented for spin-0 and spin-1/2 magnetic monopoles of magnetic charge 1gD and 2gD and for high-electric-charge objects of electric charge 20 ≤ |z| ≤ 100, for masses between 200 GeV and 4000 GeV. The search improves by approximately a factor of three the previous cross-section limits on the Drell-Yan production of magnetic monopoles and high-electric charge objects. Also, the first ATLAS limits on the photon-fusion pair production mechanism of magnetic monopoles and high-electric-charge objects are obtained

Relic Backgrounds of Gravitational Waves from Cosmic Turbulence

Turbulence may have been produced in the early universe during several kind of non-equilibrium processes. Periods of cosmic turbulence may have left a detectable relic in the form of stochastic backgrounds of gravitational waves. In this paper we derive general expressions for the power spectrum of the expected signal. Extending previous works on the subject, we take into account the effects of a continuous energy injection power and of magnetic fields. Both effects lead to considerable deviations from the Kolmogorov turbulence spectrum. We applied our results to determine the spectrum of gravity waves which may have been produced by neutrino inhomogeneous diffusion and by a first order phase transition. We show that in both cases the expected signal may be in the sensitivity range of LISA.Comment: 25 pages, 1 figur

Search for dark photons from Higgs boson decays via ZH production with a photon plus missing transverse momentum signature from pp collisions at √s = 13 TeV with the ATLAS detector

This paper describes a search for dark photons (γd) in proton-proton collisions at √s = 13 TeV at the Large Hadron Collider (LHC). The dark photons are searched for in the decay of Higgs bosons (H → γγd) produced through the ZH production mode. The transverse mass of the system, made of the photon and the missing transverse momentum from the non-interacting γd, presents a distinctive signature as it peaks near the Higgs boson mass. The results presented use the total Run-2 integrated luminosity of 139 fb−1 recorded by the ATLAS detector at the LHC. The dominant reducible background processes are estimated using data-driven techniques. A Boosted Decision Tree technique is adopted to enhance the sensitivity of the search. As no excess is observed with respect to the Standard Model prediction, an observed (expected) upper limit on the branching ratio BR(H → γγd) of 2.28% ( (2.82+1.33−0.84%) is set at 95% CL for massless γd. For massive dark photons up to 40 GeV, the observed (expected) upper limits on BR(H → γγd) at 95% confidence level is found within the [2.19,2.52]% ([2.71,3.11]%) range

Searches for lepton-flavour-violating decays of the Higgs boson into eτ and μτ in √s=13 TeV pp collisions with the ATLAS detector

This paper presents direct searches for lepton flavour violation in Higgs boson decays, H → eτ and H → μτ, performed using data collected with the ATLAS detector at the LHC. The searches are based on a data sample of proton-proton collisions at a centre-of-mass energy √s = 13 TeV, corresponding to an integrated luminosity of 138 fb−1. Leptonic (τ → ℓνℓντ) and hadronic (τ → hadrons ντ) decays of the τ-lepton are considered. Two background estimation techniques are employed: the MC-template method, based on data-corrected simulation samples, and the Symmetry method, based on exploiting the symmetry between electrons and muons in the Standard Model backgrounds. No significant excess of events is observed and the results are interpreted as upper limits on lepton-flavour-violating branching ratios of the Higgs boson. The observed (expected) upper limits set on the branching ratios at 95% confidence level, β(H → eτ) < 0.20% β(0.12%) and (H → μτ ) < 0.18% (0.09%), are obtained with the MC-template method from a simultaneous measurement of potential H → eτ and H → μτ signals. The best-fit branching ratio difference, β(H → μτ) → β(H → eτ), measured with the Symmetry method in the channel where the τ-lepton decays to leptons, is (0.25 ± 0.10)%, compatible with a value of zero within 2.5σ

Search for vector-boson resonances decaying into a top quark and a bottom quark using pp collisions at √s = 13 TeV with the ATLAS detector

A search for a new massive charged gauge boson, W′, is performed with the ATLAS detector at the LHC. The dataset used in this analysis was collected from proton-proton collisions at a centre-of-mass energy of √s = 13 TeV, and corresponds to an integrated luminosity of 139 fb−1. The reconstructed tb invariant mass is used to search for a W′ boson decaying into a top quark and a bottom quark. The result is interpreted in terms of a W′ boson with purely right-handed or left-handed chirality in a mass range of 0.5–6 TeV. Different values for the coupling of the W′ boson to the top and bottom quarks are considered, taking into account interference with single-top-quark production in the s-channel. No significant deviation from the background prediction is observed. The results are expressed as upper limits on the W′ → tb production cross-section times branching ratio as a function of the W′-boson mass and in the plane of the coupling vs the W′-boson mass