4,836 research outputs found
Clock Synchronization based on Second-Order Quantum Coherence of Entangled Photons
We present an algorithm for synchronizing two clocks based on second-order
quantum interference between entangled photons generated by parametric
down-conversion. The procedure is distinct from the standard Einstein two-way
clock synchronization method in that photon correlations are used to define
simultaneous events in the frame of reference of a Hong-Ou-Mandel (HOM)
interferometer. Once the HOM interferometer is balanced, by use of an
adjustable optical delay in one arm, arrival times of simultaneously generated
photons are recorded by each clock. Classical information on the arrival times
is sent from one clock to the other, and a correlation of arrival times is done
to determine the clock offset.Comment: 5 pages, 2 figures. ReVTeX
Girl or boy? Prenatal lead, cadmium and mercury exposure and the secondary sex ratio in the ALSPAC study
AbstractThe aim of this study was to evaluate the effect of prenatal exposure to lead, cadmium and mercury levels on the secondary sex ratio. Whole blood samples were collected from pregnant women enrolled in the Avon Longitudinal Study of Parents and Children (ALSPAC) study at a median gestational age of 11 weeks and were analyzed for lead, cadmium and mercury. Regression analysis was used to identify associations between maternal lead, cadmium and mercury levels and the secondary sex ratio with adjustment for confounders. There was no evidence for associations between maternal lead, cadmium or mercury levels and the secondary sex ratio in this sample. It appears unlikely that alterations in the secondary sex ratio are influenced by exposure to heavy metals, but further work should be done in large cohorts in other countries to confirm these findings
Adverse effects of maternal lead levels on birth outcomes in the ALSPAC study:a prospective birth cohort study
Intake of game birds in the UK:assessment of the contribution to the dietary intake of lead by women of childbearing age and children
AbstractObjectiveConcern has recently been expressed about Pb levels in Pb-shot game meat. Our aim was to determine the consumption of game birds in a representative sample population in the UK, and in children and women of childbearing age in particular.DesignPopulation-based cross-sectional cohort study. Data from 4 d diet diaries from the UK National Diet and Nutrition Survey (NDNS; 2008–2010) were extracted to analyse data on game bird consumption in the sample population, in women of childbearing age (15–45 years old) and in children ≤6 years old.SettingHome-based study in representative areas of the UK.SubjectsParticipants in the NDNS (2008–2010; n 2126, age 1·5 to >65 years).ResultsFifty-eight participants (2·7 %) reported eating game birds. The mean intake was 19·5 (sd 18·1) g/d (median 15·6, range 1·3–92·9 g/d). In women of childbearing age (15–45 years), 11/383 (2·9 %) reported eating game birds, with a mean intake of 22·4 (sd 25·8) g/d (median 15·6, range 2·0–92·9 g/d). In children aged ≤6 years old, 3/342 (0·9 %) were reported as eating game birds, with a mean intake of 6·8 (sd 9·7) g/d (median 2·4, range 1·3–23·2 g/d).ConclusionsThe prevalence of consumption of game birds by women of childbearing age and children ≤6 years old was relatively low and intakes were small. However, any exposure to Pb in these two groups is undesirable. As are uncertainties about the ability of the diet diary method to capture the consumption of food items that are infrequently consumed, alternative methods of capturing these data should be used in future studies.</jats:sec
Meniere’s, Migraine & Motion Sickness
CONCLUSION Elevated MSS in MD is likely to be a consequence of the onset of MD and not migraine per se.
OBJECTIVES Pathologies of the vestibular system influence motion sickness susceptibility (MSS). Bilateral vestibular deficits lower MSS, vestibular neuritis or benign paroxysmal positional vertigo have little overall effect, whereas vestibular migraine elevates MSS. However, less is known about MSS in Meniere’s disease (MD), a condition in which many patients experience vestibular loss and migraine symptoms.
METHODS We conducted an online survey that posed diagnostic and disease questions before addressing frequency of headaches, migraines, visual display dizziness (VDD), syncope, social life and work impact of dizziness (SWID4) and motion sickness susceptibility (MSSQ). The two groups were: diagnosed MD individuals with hearing loss (n=751) and non-MD individuals in the control group (n=400).
RESULTS The MD group showed significantly elevated MSS, more headache and migraine, increased VDD, higher SWID4 scores, and increased syncope. MSS was higher in MD than controls only after the development of MD but not before, nor in childhood. Although elevated in MD compared with controls, MSS was lower than migraine patients from past data. Multivariate analysis revealed VDD, SWID4 and MSS in adulthood as the strongest predictors of MD, but not headache nor migraine
The “broken escalator” phenomenon: Vestibular dizziness interferes with locomotor adaptation
BACKGROUND: Although vestibular lesions degrade postural control we do not know the relative contributions of the magnitude of the vestibular loss and subjective vestibular symptoms to locomotor adaptation. OBJECTIVE: To study how dizzy symptoms interfere with adaptive locomotor learning. METHODS: We examined patients with contrasting peripheral vestibular deficits, vestibular neuritis in the chronic stable phase (n = 20) and strongly symptomatic unilateral Meniere’s disease (n = 15), compared to age-matched healthy controls (n = 15). We measured locomotor adaptive learning using the “broken escalator” aftereffect, simulated on a motorised moving sled. RESULTS: Patients with Meniere’s disease had an enhanced “broken escalator” postural aftereffect. More generally, the size of the locomotor aftereffect was related to how symptomatic patients were across both groups. Contrastingly, the degree of peripheral vestibular loss was not correlated with symptom load or locomotor aftereffect size. During the MOVING trials, both patient groups had larger levels of instability (trunk sway) and reduced adaptation than normal controls. CONCLUSION: Dizziness symptoms influence locomotor adaptation and its subsequent expression through motor aftereffects. Given that the unsteadiness experienced during the “broken escalator” paradigm is internally driven, the enhanced aftereffect found represents a new type of self-generated postural challenge for vestibular/unsteady patients
Universality in escape from a modulated potential well
We show that the rate of activated escape from a periodically modulated
potential displays scaling behavior versus modulation amplitude . For
adiabatic modulation of an optically trapped Brownian particle, measurements
yield with . The theory gives
in the adiabatic limit and predicts a crossover to scaling as
approaches the bifurcation point where the metastable state disappears.Comment: 4 pages, 3 figure
Think Different: Applying the Old Macintosh Mantra to the Computability of the SUSY Auxiliary Field Problem
Starting with valise supermultiplets obtained from 0-branes plus field
redefinitions, valise adinkra networks, and the "Garden Algebra," we discuss an
architecture for algorithms that (starting from on-shell theories and, through
a well-defined computation procedure), search for off-shell completions. We
show in one dimension how to directly attack the notorious "off-shell auxiliary
field" problem of supersymmetry with algorithms in the adinkra network-world
formulation.Comment: 28 pages, 1 figur
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately regulated to result in more complex morphogenetic events, such as tubular sprouting, fusion, and network formation. We show here that VEGF-A controls angiogenic sprouting in the early postnatal retina by guiding filopodial extension from specialized endothelial cells situated at the tips of the vascular sprouts. The tip cells respond to VEGF-A only by guided migration; the proliferative response to VEGF-A occurs in the sprout stalks. These two cellular responses are both mediated by agonistic activity of VEGF-A on VEGF receptor 2. Whereas tip cell migration depends on a gradient of VEGF-A, proliferation is regulated by its concentration. Thus, vessel patterning during retinal angiogenesis depends on the balance between two different qualities of the extracellular VEGF-A distribution, which regulate distinct cellular responses in defined populations of endothelial cells
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