Development of the Concept of a Healthy Lifestyle Festival on the Site of Ural Federal University

In this article is purposed hold a healthy lifestyle festival on the site of Ural Federal University, because the author’s survey results of inhabits of Yekaterinburg showed their interest in healthy lifestyle and lack of full knowledge. The analysis of healthy lifestyle festivals in Russia and the world for evaluation of their program was given. This experience helped us preparation the program of the event.Описан анализ фестивалей здорового образа жизни (ЗОЖ), проводимых в России и мире, который дает представление об их основных направлениях, а также интересе населения к подобным мероприятиям. Проведен авторский опрос об интересующих жителей Екатеринбурга вопросах валеологии. Результаты показали повышенный интерес респондентов к своему здоровью и недостаточную информированность в вопросах ЗОЖ. Разработано предложение по проведению образовательного фестиваля ЗОЖ на базе Уральского федерального университета

SENSOR DETERMINATION OF THE DEGREE OF WHEAT GRAIN DAMAGE BY SMUT MUSHROOMS

The article describes the developed method for determining the degree of damage to wheat grain by smut fungi, which allows to determine its non-toxic level, increase the measurement accuracy and reliability of the results, to ensure the simplicity of processing the results, to prevent further damage to wheat grain and to ensure its safety without compromising quality. As smut reduces the yield, worsens the quality of grain and grain products, and improving the sanitary condition of grain raw materials is an urgent problem. It was established that the developed method allows to significantly reduce the cost of analysis by 300-320 rubles, reduce the time for analysis by 20-25 minutes, reduce the measurement error from 15% to 10%

Mixing process in the preparation of feed pellets at technological conditions rational parametres choice

The mixing of ingredients – the most important process step in the manufacture of fodder pellets. The technology involves using molasses (warmed to 30–40 °C) as a binder. In its composition is administered a mixture of salts of trace elements (copper sulfate, zinc sulfate, cobalt carbonate, potassium iodide, ferrous sulfate, manganese sulfate, sodium selenite), vitamins, salt, magnesium oxide, feed limestone, mono calcium phosphate and lime. Research on the development of feed pellets were carried out in laboratory conditions using experimental equipment. Mixer-reactor created the conditions for heating and temperature control of mass be mixed due to the occurring chemical reaction between water contained in the molasses, and the presence of oxides of calcium and magnesium. The choice of rational parameters of the mixing process upon receipt of fodder pellets allows to provide the high quality product with minimal energy costs. The ranges of the input information factors selected with the aid of a central rotatable uniforms-planning allowed with 56 experiments in a third-multiple replication to obtain the regression equation adequately describing the mixing process. The main factors were: the content of molasses, %; the content of calcium oxide, %; frequency of rotation of the stirrer, rpm; the content of salt in the recipe, %; the temperature of blending, °C. Output factors – productivity, kg/h; energy consumption, kWh; homogeneity of mixing, %. In the result of experiments impact factors and mathematical model of the process that allows to define output parameters within chosen ranges of variation of input factors are obtained. Greatest influence – the content of molasses in the product, the lowest – content of salt in the recipe. Efficiency of mixing hard distributed components pertaining to the most important biologically active substances was evaluated. Content (% of entered) of vitamins and minerals in the pellets did not differ significantly from the values provided by the recipe (not >10%). The degree of homogeneity of the products on the distribution of vitamins and minerals were at the level to 92.4–99.6%

Use of Janus kinase inhibitors in COVID-19: a prospective observational series in 522 individuals

Janus kinase (JAK) inhibitors for the treatment of hospitalised patients with COVID-19 have been extensively studied. Initially, at the start of the pandemic outside of China, baricitinib was shown using artificial intelligence to have a potential dual anticytokine and antiviral effect, computer predictions that were then supported by mechanistic data.1–3 This included kinase assays demonstrating inhibition of host numb-associated kinases, notably AP-2-associated protein kinase 1 (AAK1) and cyclin G-associated kinase (GAK), responsible for activating protein-1 (AP-1)-mediated viral propagation and super-resolution microscopy which showed inhibition of SARS-CoV-2 entry into primary human liver spheroids.4 Based on double-blind randomised data from the Adaptive COVID-19 Treatment Trial-II (ACTT-II) under the National Institutes of Allergy and Infectious Diseases,5 it received an Emergency Use Authorisation from the United States Food and Drug Administration in November 2020, in combination with remdesevir for the treatment of hospitalised individuals with COVID-19...</p

IMPLEMENTATION OF ENERGY EFFICIENT TECHNOLOGY AS ANIMAL FEED SYSTEM THERMAL AND MECHANICAL PROCESSES

Proposed energy-efficient technology fodder in applying the vapor compression chiller. To implement the tech-nology as a system of thermal and mechanical processes designed program-logic algorithm that allows us to exercise operational control of process parameters

The probabilistic model of the process mixing of animal feed ingredients into a continuous mixer-reactor

A mathematical model of the polydisperse medium mixing process reflects its stochastic features in the form of uneven distribution of phase elements on the time of their presence in apparatus, particle size, ripple retention of the apparatus, random distribution of the material and thermal phase flows of the working volume, heterogeneity of the medium physical- and chemical properties, complicated by chemical reaction. For the mathematical description of the mixing process of animal feed ingredients in the presence of chemical reaction the system of differential equations of Academician V.V. Kafarov was used. Proposed by him hypothesis based on the theory of Markov’s processes stating that "any multicomponent mixture can be considered as the result of an iterative process of mixing the two components to achieve the desired uniformity of all the ingredients in the mixture" allows us to consider a process of mixing binary composition in a paddle mixer in the form of differential equations of two ingredients concentration numerous changes until it becomes a homogenous mixture. It was found out that the mixing process of the two-component mixture is determined in a paddle mixer with a constant mixing speed and a limit (equilibrium) dispersion of the ingredients in the mixture i.e. with its uniformity. Adjustment of the model parameters was carried out according to the results of experimental studies on mixing the crushed wheat with metallomagnetic impurity, which was a key (indicator) component. According to the best values of the constant of the continuous mixing speed and the equilibrium disperse values of the ingredients contents, the mathematical model parameters identification was carried out. The results obtained are used to develop a new generation mixer design

Contrasting effects of α-synuclein and γ-synuclein on the phenotype of cysteine string protein α (CSPα) null mutant mice suggest distinct function of these proteins in neuronal synapses.

In neuronal synapses, neurotransmitter-loaded vesicles fuse with presynaptic plasma membrane in a complex sequence of tightly regulated events. The assembly of specialized SNARE complexes plays a pivotal role in this process. The function of the chaperone cysteine string protein α (CSPα) is important for synaptic SNARE complex formation, and mice lacking this protein develop severe synaptic dysfunction and neurodegeneration that lead to their death within 3 months after birth. Another presynaptic protein, α-synuclein, also potentiates SNARE complex formation, and its overexpression rescues the phenotype of CSPα null mutant mice, although these two proteins use different mechanisms to achieve this effect. α-Synuclein is a member of a family of three related proteins whose structural similarity suggests functional redundancy. Here, we assessed whether γ-synuclein shares the ability of α-synuclein to bind synaptic vesicles and ameliorate neurodegeneration caused by CSPα deficiency in vivo. Although the N-terminal lipid-binding domains of the two synucleins showed similar affinity for purified synaptic vesicles, the C-terminal domain of γ-synuclein was not able to interact with synaptobrevin-2/VAMP2. Consequently, overexpression of γ-synuclein did not have any noticeable effect on the phenotype of CSPα null mutant mice. Our data suggest that the functions of α- and γ-synucleins in presynaptic terminals are not fully redundant

Optimization of the technology of fodder briquettes-licks with the use of a steam compression heat pump

In conditions of industrial maintenance of animals, their health is noticeably weakening, in the majority of the body, profound metabolic disorders are noted, and productivity is reduced. In such conditions it is necessary to use feed additives in the form of briquettes-licks, able to compensate for the lack of micro and macro elements, vitamins and many other substances. Intensification of feed production through the use of new advanced technologies allows to improve the quality of products and reduce losses in its production. The technologies used for briquettes-licks and equipment for their production do not always allow to provide high quality products and achieve the necessary effect when fed. In addition, they are energy-intensive, do not imply the use of secondary energy carriers. Therefore, the creation of a functional product, combining a complex of substances necessary for animal feeding, and the development of an energy-efficient method for its production is topical. The proposed technology makes it possible to obtain feed briquettes with high homogeneity and a specified content of biologically active substances, to ensure a longer-term preservation of the products. The developed line provides for the maximum rapid cooling of the finished product and a reduction in the specific energy consumption for its production as a result of the heat of spent coolants. The high-quality licks produced were homogeneous in their composition, resistant to unfavorable conditions. They are characterized by a higher stability of structural and mechanical properties and stability of storage quality for a long time: after twelve months, the technological properties of the products have not changed, signs of damage associated with increased humidity of the environment have not been noted. On the surface of briquettes, signs of development of microflora were not observed. The values of microbiological quality indicators were within acceptable limits. The development of energy-efficient method of its production is relevant. The proposed technology allows to obtain feed pellets with high uniformity and specify the content of biologically active substances, provide a long-term preservation products. It gives the possibility of issuing briquettes with high quality. In the developed line provides the most rapid cooling of the finished product and the reduction of specific energy consumption for its production as a result of the use of waste heat coolant. High licks were homogeneous resistant to adverse conditions and maintain the structural and mechanical properties and quality for a long time .If stored for twelve months technological properties of the product have not changed, deterioration of symptoms associated with high ambient humidity, it is noted. On the surface of briquettes signs of microflora is not observed. Values of microbiological quality parameters were within acceptable limits