The gut microbiome: Relationships with disease and opportunities for therapy.

Over the past decade, our view of human-associated microbes has expanded beyond that of a few species toward an appreciation of the diverse and niche-specialized microbial communities that develop in the human host with chronological age. The largest reservoir of microbes exists in the distal gastrointestinal tract, both in the lumen, where microbes facilitate primary and secondary metabolism, and on mucosal surfaces, where they interact with host immune cell populations. While local microbial-driven immunomodulation in the gut is well described, more recent studies have demonstrated a role for the gut microbiome in influencing remote organs and mucosal and hematopoietic immune function. Unsurprisingly, therefore, perturbation to the composition and function of the gut microbiota has been associated with chronic diseases ranging from gastrointestinal inflammatory and metabolic conditions to neurological, cardiovascular, and respiratory illnesses. Considerable effort is currently focused on understanding the natural history of microbiome development in humans in the context of health outcomes, in parallel with improving our knowledge of microbiome-host molecular interactions. These efforts ultimately aim to develop effective approaches to rehabilitate perturbed human microbial ecosystems as a means to restore health or prevent disease. This review details the role of the gut microbiome in modulating host health with a focus on immunomodulation and discusses strategies for manipulating the gut microbiome for the management or prevention of chronic inflammatory conditions

The Family Caregiver\u27s Experience: Examining the Positive and Negative Aspects of Compassion Satisfaction and Compassion Fatigue Using a Stress Process Model

Family caregivers significantly contribute to the provision of health care for their family members. This complex care can result in stress that may lead to both positive and negative consequences for the caregiver. Current literature tends to focus on negative consequences such as caregiver burden. Therefore, compassion fatigue and compassion satisfaction are proposed as concepts that may better reflect the family caregiving experience. Compassion fatigue is comprised of two components; burnout and secondary traumatic stress. The purpose of this study was to examine the concept of compassion fatigue and compassion satisfaction among family caregivers and to explore the relationship between caregiver burden and compassion fatigue to determine which characteristics were predictive for the level of compassion fatigue. Using a cross sectional descriptive survey design with a convenience sample, 168 family caregivers providing care for family members with chronic illness completed a web based survey. The survey included a demographic questionnaire, the Caregiver Burden Interview, the Professional Quality of Life measure and the Brief COPE inventory. Results from this study revealed that the majority of participants reported a high level of caregiver burden, a moderate level of burnout, equal division of low and moderate levels of secondary traumatic stress, and a moderate level of compassion satisfaction. Analysis suggested that caregiver burden and compassion fatigue are similar, but distinct concepts and supported the use of compassion fatigue and compassion satisfaction as caregiving outcomes for family caregivers. Characteristics related to gender, caregiving demands, and caregiver resources resulted in differences found in compassion fatigue and compassion satisfaction scores with caregiver burden as the primary predictor that explained a substantial amount of variance in compassion fatigue scores

Espiritu Sin Nombre : Names in Becquer

The most striking feature of an onomastic study of the Rimas, Gustavo Adolfo Becquer\u27s major poetic creation, is the extreme paucity of given names.1 Only four such names appear in all of the Rimas (Ofelia, Minerva, Lazaro, Dante), but even these few must be qualified for the purpose of this study. They are not properly given names, actually identifying characters or people addressed by the poet in his lyrics. All four have connotative and/or metaphorical functions as employed in their respective poems.2 In point of fact, then, there are no personal names at all uttered in the seventy-nine poems that constitute this significant body of verse

Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease.

The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism of environmental, dietary, and host-derived substrates, which produce bioactive metabolites. Perturbations to the composition and associated metabolic output of the gut microbiome have been associated with a number of chronic liver diseases, including nonalcoholic fatty liver disease (NAFLD). Here, we review the rapidly evolving suite of next-generation techniques used for studying gut microbiome composition, functional gene content, and bioactive products and discuss relationships with the pathogenesis of NAFLD

The Ursinus Weekly, May 9, 1966

Student governments to merge: Campus opinion favors merger; Next year seen as likely time • MSGA representatives announced: Elections held, merger or not • Pettit advises men on draft • Bang up job on Spring Festival • Campus Chest adds new charity • Editor reviews The Tender Trap • Editorial: But why merge? • Letters to the editor • Powerful scope atop Pfahler shoots moon, stars, planets: Students, faculty view galaxies millions of light years away • S-ball team swamps Penn; Loses to WC in 13 innings • Troster wins pair; Bears lose to Drexel • Women\u27s tennis team splits 2 matches • UC thumps Albright, falls to Leb. Valley • New golf team wins • Greek gleaningshttps://digitalcommons.ursinus.edu/weekly/1225/thumbnail.jp

The ISCIP Analyst, Volume XVI, Issue 6

This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy

The ISCIP Analyst, Volume V, Issue 10

This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy