46 research outputs found
Effect of Electron Energy Distribution Function on Power Deposition and Plasma Density in an Inductively Coupled Discharge at Very Low Pressures
A self-consistent 1-D model was developed to study the effect of the electron
energy distribution function (EEDF) on power deposition and plasma density
profiles in a planar inductively coupled plasma (ICP) in the non-local regime
(pressure < 10 mTorr). The model consisted of three modules: (1) an electron
energy distribution function (EEDF) module to compute the non-Maxwellian EEDF,
(2) a non-local electron kinetics module to predict the non-local electron
conductivity, RF current, electric field and power deposition profiles in the
non-uniform plasma, and (3) a heavy species transport module to solve for the
ion density and velocity profiles as well as the metastable density. Results
using the non-Maxwellian EEDF model were compared with predictions using a
Maxwellian EEDF, under otherwise identical conditions. The RF electric field,
current, and power deposition profiles were different, especially at 1mTorr,
for which the electron effective mean free path was larger than the skin depth.
The plasma density predicted by the Maxwellian EEDF was up to 93% larger for
the conditions examined. Thus, the non-Maxwellian EEDF must be accounted for in
modeling ICPs at very low pressures.Comment: 19 pages submitted to Plasma Sources Sci. Techno
Genome-Wide Screen of Three Herpesviruses for Protein Subcellular Localization and Alteration of PML Nuclear Bodies
Herpesviruses are large, ubiquitous DNA viruses with complex host interactions, yet many of the proteins encoded by these viruses have not been functionally characterized. As a first step in functional characterization, we determined the subcellular localization of 234 epitope-tagged proteins from herpes simplex virus, cytomegalovirus, and Epstein–Barr virus. Twenty-four of the 93 proteins with nuclear localization formed subnuclear structures. Twelve of these localized to the nucleolus, and five at least partially localized with promyelocytic leukemia (PML) bodies, which are known to suppress viral lytic infection. In addition, two proteins disrupted Cajal bodies, and 19 of the nuclear proteins significantly decreased the number of PML bodies per cell, including six that were shown to be SUMO-modified. These results have provided the first functional insights into over 120 previously unstudied proteins and suggest that herpesviruses employ multiple strategies for manipulating nuclear bodies that control key cellular processes