Senior Recital: Kyle Pridgen, percussion

This recital is presented in partial fulfillment of requirements for the degree Bachelor of Music in Music Education. Mr. Pridgen studies percussion with John Lawless.https://digitalcommons.kennesaw.edu/musicprograms/1528/thumbnail.jp

Reconciling the influence of task-set switching and motor inhibition processes on stop signal after-effects.

Executive response functions can be affected by preceding events, even if they are no longer associated with the current task at hand. For example, studies utilizing the stop signal task have reported slower response times to "GO" stimuli when the preceding trial involved the presentation of a "STOP" signal. However, the neural mechanisms that underlie this behavioral after-effect are unclear. To address this, behavioral and electroencephalography (EEG) measures were examined in 18 young adults (18-30 years) on "GO" trials following a previously "Successful Inhibition" trial (pSI), a previously "Failed Inhibition" trial (pFI), and a previous "GO" trial (pGO). Like previous research, slower response times were observed during both pSI and pFI trials (i.e., "GO" trials that were preceded by a successful and unsuccessful inhibition trial, respectively) compared to pGO trials (i.e., "GO" trials that were preceded by another "GO" trial). Interestingly, response time slowing was greater during pSI trials compared to pFI trials, suggesting executive control is influenced by both task set switching and persisting motor inhibition processes. Follow-up behavioral analyses indicated that these effects resulted from between-trial control adjustments rather than repetition priming effects. Analyses of inter-electrode coherence (IEC) and inter-trial coherence (ITC) indicated that both pSI and pFI trials showed greater phase synchrony during the inter-trial interval compared to pGO trials. Unlike the IEC findings, differential ITC was present within the beta and alpha frequency bands in line with the observed behavior (pSI > pFI > pGO), suggestive of more consistent phase synchrony involving motor inhibition processes during the ITI at a regional level. These findings suggest that between-trial control adjustments involved with task-set switching and motor inhibition processes influence subsequent performance, providing new insights into the dynamic nature of executive control

EFFECT OF TWO KINESIO TAPE TECHNIQUES ON KNEE KINEMATICS DURING A DROP JUMP TEST

This study investigated the effects of Kinesio® Tape on knee kinematics during a drop jump (DJ) test in 20 young women that had or were currently participating in competitive basketball or volleyball. Three taping conditions were randomly applied to the dominant leg of each participant: no tape (NT), gluteus medius (GM) facilitation, and spiral technique (ST). Multiple 3 x 2 RMANOVAs assessed the differences in peak knee flexion and abduction, and time to peak (TTP) angles, between taping conditions. No significant differences were found for peak knee angles or TTP, suggesting that GM and ST Kinesio® Tape applications did not alter measured knee kinematics during a DJ test. Any mitigation strategy should not depend on Kinesio® Tape alone and take a comprehensive approach that includes strength and neuromuscular training

Percussion Ensemble Spring Concert

Kennesaw State University School of Music presents Percussion Ensemble Spring Concert.https://digitalcommons.kennesaw.edu/musicprograms/1406/thumbnail.jp

2014 Kennesaw State Festival of New Music

Kennesaw State University School of Music presents the 2014 Kennesaw State Festival of New Music with featured guest composer, Chen Yi.https://digitalcommons.kennesaw.edu/musicprograms/1374/thumbnail.jp

Choral Ensembles Spring Concert

Kennesaw State University School of Music presents Choral Ensembles Spring Concert.https://digitalcommons.kennesaw.edu/musicprograms/1363/thumbnail.jp

Phosphorylation of the HCN channel auxiliary subunit TRIP8b is altered in an animal model of temporal lobe epilepsy and modulates channel function

Temporal lobe epilepsy (TLE) is a prevalent neurological disorder with many patients experiencing poor seizure control with existing anti-epileptic drugs. Thus, novel insights into the mechanisms of epileptogenesis and identification of new drug targets can be transformative. Changes in ion channel function have been shown to play a role in generating the aberrant neuronal activity observed in TLE. Previous work demonstrates that hyperpolarization-activated cyclic nucleotide-gated (HCN) channels regulate neuronal excitability and are mislocalized within CA1 pyramidal cells in a rodent model of TLE. The subcellular distribution of HCN channels is regulated by an auxiliary subunit, tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b), and disruption of this interaction correlates with channel mislocalization. However, the molecular mechanisms responsible for HCN channel dysregulation in TLE are unclear. Here we investigated whether changes in TRIP8b phosphorylation are sufficient to alter HCN channel function. We identified a phosphorylation site at residue Ser237 of TRIP8b that enhances binding to HCN channels and influences channel gating by altering the affinity of TRIP8b for the HCN cytoplasmic domain. Using a phosphospecific antibody, we demonstrate that TRIP8b phosphorylated at Ser237 is enriched in CA1 distal dendrites and that phosphorylation is reduced in the kainic acid model of TLE. Overall, our findings indicate that the TRIP8b-HCN interaction can be modulated by changes in phosphorylation and suggest that loss of TRIP8b phosphorylation may affect HCN channel properties during epileptogenesis. These results highlight the potential of drugs targeting posttranslational modifications to restore TRIP8b phosphorylation to reduce excitability in TLE