949 research outputs found
Classical noise and flux: the limits of multi-state atom lasers
By direct comparison between experiment and theory, we show how the classical
noise on a multi-state atom laser beam increases with increasing flux. The
trade off between classical noise and flux is an important consideration in
precision interferometric measurement. We use periodic 10 microsecond
radio-frequency pulses to couple atoms out of an F=2 87Rb Bose-Einstein
condensate. The resulting atom laser beam has suprising structure which is
explained using three dimensional simulations of the five state
Gross-Pitaevskii equations.Comment: 4 pages, 3 figure
A Bose-Einstein condensate in a random potential
An optical speckle potential is used to investigate the static and dynamic
properties of a Bose-Einstein condensate in the presence of disorder. For
strong disorder the condensate is localized in the deep wells of the potential.
With smaller levels of disorder, stripes are observed in the expanded density
profile and strong damping of dipole and quadrupole oscillations is seen.
Uncorrelated frequency shifts of the two modes are measured for a weak disorder
and are explained using a sum-rules approach and by the numerical solution of
the Gross-Pitaevskii equation
Minimally-destructive detection of magnetically-trapped atoms using frequency-synthesised light
We present a technique for atomic density measurements by the off-resonant
phase-shift induced on a two-frequency, coherently-synthesised light beam. We
have used this scheme to measure the column density of a magnetically trapped
atom cloud and to monitor oscillations of the cloud in real time by making over
a hundred non-destructive local density measurments. For measurements using
pulses of 10,000-100,000 photons lasting ~10 microsecond, the precision is
limited by statistics of the photons and the photodiode avalanche. We explore
the relationship between measurement precision and the unwanted loss of atoms
from the trap and introduce a figure of merit that characterises it. This
method can be used to probe the density of a BEC with minimal disturbance of
its phase.Comment: Submitted to New Journal of Physic
Microfluidic chromatography for early stage evaluation of biopharmaceutical binding and separation conditions
Optimization of separation conditions for biopharmaceuticals requires evaluation of a large number of process variables. To miniaturize this evaluation a microfluidic column (1.5 mu L volume and 1cm height) was fabricated and packed with a typical process scale resin. The device was assessed by comparison to a protein separation at conventional laboratory scale. This was based upon measurement of the quality of packing and generation of breakthrough and elution curves. Dynamic binding capacities from the microfluidic column compared well with the laboratory scale. Microfluidic scale gradient elution separations also equated to the laboratory column three orders of magnitude larger in scale
Effect of optical disorder and single defects on the expansion of a Bose-Einstein condensate in a one-dimensional waveguide
We investigate the one-dimensional expansion of a Bose-Einstein condensate in
an optical guide in the presence of a random potential created with optical
speckles. With the speckle the expansion of the condensate is strongly
inhibited. A detailed investigation has been carried out varying the
experimental conditions and checking the expansion when a single optical defect
is present. The experimental results are in good agreement with numerical
calculations based on the Gross-Pitaevskii equation.Comment: 5 pages, 5 figure
Test of the quantumness of atom-atom correlations in a bosonic gas
It is shown how the quantumness of atom-atom correlations in a trapped
bosonic gas can be made observable. Application of continuous feedback control
of the center of mass of the atomic cloud is shown to generate oscillations of
the spatial extension of the cloud, whose amplitude can be directly used as a
characterization of atom-atom correlations. Feedback parameters can be chosen
such that the violation of a Schwarz inequality for atom-atom correlations can
be tested at noise levels much higher than the standard quantum limit
Non-destructive, dynamic detectors for Bose-Einstein condensates
We propose and analyze a series of non-destructive, dynamic detectors for
Bose-Einstein condensates based on photo-detectors operating at the shot noise
limit. These detectors are compatible with real time feedback to the
condensate. The signal to noise ratio of different detection schemes are
compared subject to the constraint of minimal heating due to photon absorption
and spontaneous emission. This constraint leads to different optimal operating
points for interference-based schemes. We find the somewhat counter-intuitive
result that without the presence of a cavity, interferometry causes as much
destruction as absorption for optically thin clouds. For optically thick
clouds, cavity-free interferometry is superior to absorption, but it still
cannot be made arbitrarily non-destructive . We propose a cavity-based
measurement of atomic density which can in principle be made arbitrarily
non-destructive for a given signal to noise ratio
Precision atomic gravimeter based on Bragg diffraction
We present a precision gravimeter based on coherent Bragg diffraction of
freely falling cold atoms. Traditionally, atomic gravimeters have used
stimulated Raman transitions to separate clouds in momentum space by driving
transitions between two internal atomic states. Bragg interferometers utilize
only a single internal state, and can therefore be less susceptible to
environmental perturbations. Here we show that atoms extracted from a
magneto-optical trap using an accelerating optical lattice are a suitable
source for a Bragg atom interferometer, allowing efficient beamsplitting and
subsequent separation of momentum states for detection. Despite the inherently
multi-state nature of atom diffraction, we are able to build a Mach-Zehnder
interferometer using Bragg scattering which achieves a sensitivity to the
gravitational acceleration of with an
integration time of 1000s. The device can also be converted to a gravity
gradiometer by a simple modification of the light pulse sequence.Comment: 13 pages, 11 figure
Effects on the maternofetal unit of the rabbit model after substitution of the amniotic fluid with perfluorocarbons
Objectives: Exchanging amniotic fluid (AF) with perfluorocarbon (PFC) may serve as a medium for fetoscopic surgery. This study evaluates the distribution and physiologic effects of intraamniotic PFC as a medium for fetoscopy. Methods: Fetuses of 17 pregnant rabbits underwent either exchange of the AF with PFC, electrolyte solution (ES), or control. The quality of vision during fetoscopy was assessed in AF and PFC. After 6 h, we determined the distribution of PFC in the maternofetal unit. Results: Quality of vision during fetoscopy was better in PFC than with AF. There was no difference in fetal survival between the study groups. PFC was demonstrated on X-ray in the pharynx of 4 fetuses, and the esophagus in 1. Conclusions: PFC provided an ideal medium for fetoscopy without fetal compromise. Copyright (c) 2005 S. Karger AG, Basel
Phenotypic responses to interspecies competition and commensalism in a naturally derived microbial co-culture
The fundamental question of whether different microbial species will co-exist or compete in a given environment depends on context, composition and environmental constraints. Model microbial systems can yield some general principles related to this question. In this study we employed a naturally occurring co-culture composed of heterotrophic bacteria, Halomonas sp. HL-48 and Marinobacter sp. HL- 58, to ask two fundamental scientific questions: 1) how do the phenotypes of two naturally co-existing species respond to partnership as compared to axenic growth? and 2) how do growth and molecular phenotypes of these species change with respect to competitive and commensal interactions? We hypothesized – and confirmed – that co-cultivation under glucose as the sole carbon source would result in competitive interactions. Similarly, when glucose was swapped with xylose, the interactions became commensal because Marinobacter HL-58 was supported by metabolites derived from Halomonas HL- 48. Each species responded to partnership by changing both its growth and molecular phenotype as assayed via batch growth kinetics and global transcriptomics. These phenotypic responses depended on nutrient availability and so the environment ultimately controlled how they responded to each other. This simplified model community revealed that microbial interactions are context-specific and different environmental conditions dictate how interspecies partnerships will unfold
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