The significance of ACTH for the process of formation of complex heparin compounds in the blood during immobilization stress

Adrenocorticotropin (ACTH) was administered to rats at different times following adrenalectomy. Adrenocorticotropin caused a significant increase in the formation of heparin complexes even in the absence of stress factor. When ACTH secretion is blocked, immobilization stress is not accompanied by an increase in the process of complex formation. The effect of ACTH on the formation of heparin complexes was mediated through its stimulation of the adrenal cortex

The role of ACTH and glucocorticoids in nonenzymatic fibrinolysis during immobilization stress in animals

The role of the altered hormonal status of an organism in the activation of the anticoagulative system during stress is investigated. The 30 minute immobilization stress was shown to raise significantly the nonenzymatic fibrinolytic activity of blood in rats. Combined with adrenocorticotropin (ACTH) the effect is still greater. Intravenous administration of 0.2 m1 0.01 percent solution of protamine sulphate prevented the nonenzymatic fibrinolysis induced by the stress. Administration of ACTH after protomine sulphate again raised the fibrinolysis. This suggests that ACTH stimulates the release of heparin

The effects of adrenalectomy and corticsteroid injection on the fibrinolytic activity of complex heparin compounds in the blood during immobilization

Total non-enzymatic fibrinolytic activity in the blood of rats increased three times in response to stress caused by 30 minute immobilization, and the activity of epinephrine-heparin complex increased nine times. In adrenalectomized animals, which showed a weak response to the same stress, intraperitoneal injection of hydrocortisone 30 minutes prior to immobilization normalized the response. Obtained results indicate that adrenalectomy leads to sharp reduction of heparin complexing with thromogenic proteins and epinephrine, while substitution therapy with hydrocortisone restores anticoagulation system function

Effects of hirudin-induced activation of nonenzymatic fibrinolysis during immobilization stress

The specific inhibitor of thrombin, hirudin, was used for studying the mechanism of the activating effect of ACTH and adrenalin on nonenzymatic fibrinolytic activity (NEFA), the latter characterizing the function of the anticoagulation system (ACS). Simultaneous administration of ACTH and hirudin to animals subjected to immobilization stress did not reduce the effect of ACTH on NEFA, while simultaneous administration of adrenalin and hirudin revealed a diminished effect of the former. This suggests different mechanisms of ACTH and adrenalin effects upon NEFA: the stimulating effect of norepinephrine is realized through throminogenesis followed by activation of the ACS function and by increased NEFA and therefore inhibitable by hirudin which forms an inactive complex with thrombin. In fact the stimulating effect of ACTH upon NEFA is brought about specifically by another route than thrombinogenesis and thus occurs in the presence of hirudin. Hirudin itself has no effect upon NEFA

Magazine “Okhotnichy Vestnik”: History of its Origin and Functioning in Specialized Printing Market

The history of one of the most popular Moscow magazines of nature and hunting “Okhotnichy Vestnik” (1901—1918), which for eighteen years has been associated with the trading company of the same name, is considered. The archival materials from the funds of the Russian State Historical Archive, the Central State Archive of Moscow, related to the publication and trading partnership “Okhotnichy Vestnik” are analyzed. On the basis of the historical-typological method, the program, content features of the magazin, ways of interacting with readers and competitors are studied, the reasons for its popularity during the period of historical catastrophes are considered. The novelty of the research is determined both by the empirical material itself — archival files not previously introduced into scientific circulation, and by the subject — the history of the emergence and functioning of the magazine “Okhotnichy Vestnik”. It is concluded that in the conditions of socio-political unrest and fierce competition for the reader, during the crisis of hunting journalism, “Okhotnichy Vestnik” retained the status of a fairly authoritative and influential publication thanks to the flexible policy of editors-publishers and effective methods of activity of the trade and industrial partnership “Okhotnichy Vestnik”. The history of the “Okhotnichy Vestnik” makes it possible to present a more complete picture of the formation of a new type of specialized printing

Peculiarities of formation of socially oriented strategy of economic growth of national economy

Effective development of national economy of Russia, as of any other country, is possible only under the conditions of clever use of strategic planning tools. Therefore, the authors of the article deem it expedient to characterize peculiarities of socially oriented strategy of economic growth of national economy. Thus, the article views stages of development of national economy, conducts analysis of reasons of change of economic growth rates, characterizes problems which hinder economic growth, and views variants of economic growth strategies.peer-reviewe