Designing the setup for testing of a 30 kW steam turbine

In order to investigate a low power steam turbine with a non-standard design, an experimental stand was assembled. The main tasks in the tests are to determine the turbine efficiency and obtain the turbine power dependence on the steam consumption in steady-state conditions. The stand scheme and the equipment characteristics are given. The testing technique is described. Based on obtained results, will be conclusion made about the turbine's preparedness for mass production.С целью исследования паровой турбины малой мощности с нестандартной конструкцией собран экспериментальный стенд. Основными задачами при испытаниях является определение эффективности турбины и получение зависимости мощности турбины от расхода пара в установившихся режимах. Приведена схема стенда и характеристики оборудования. Описана методика проведения испытаний. Основываясь на полученных результатах, будет сделан вывод о готовности турбины к серийному производству

Clinical and phenotypic features of conscripts with undifferentiated connective tissue dysplasia

Ural state medical university, Yekaterinburg, Russian Federation 5 military clinical hospital of national guard troops RF, Yekaterinburg, Russian Federation Examined 118 men 18-25 years, conscripts, who had no acute diseases. External signs of CTD were determined and CTD phenotypes were diagnosed on the basis of modern Russian recommendations. CTD was diagnosed in 62.7% of the conscripts (n=118). The most frequently recorded the unclassified phenotype, marfanoid appearance and joint hypermobility syndrome. Men with CTD had lower BMI values, more severe performance anxiety, asthenia, autonomic disorders, joints pain, back pain and heart pain.Обследовали 118 мужчин 18—25 лет, военнослужащих по призыву, которые на момент исследования не имели острых заболеваний. Определяли внешние признаки ДСТ и диагностировали фенотипы НДСТ на основании современных российских рекомендаций. НДСТ выявлена у 62,7%. Чаще других регистрировался неклассифицируемый фенотип, марфаноидная внешность и синдром гипермобильности суставов. Мужчины с НДСТ отличались меньшими значениями ИМТ, более выраженными показателями тревоги, астении, вегетативных нарушений, болями в суставах, спине и сердце

Clinical and phenotypic features of conscripts with undifferentiated connective tissue dysplasia

Ural state medical university, Yekaterinburg, Russian Federation 5 military clinical hospital of national guard troops RF, Yekaterinburg, Russian Federation Examined 118 men 18-25 years, conscripts, who had no acute diseases. External signs of CTD were determined and CTD phenotypes were diagnosed on the basis of modern Russian recommendations. CTD was diagnosed in 62.7% of the conscripts (n=118). The most frequently recorded the unclassified phenotype, marfanoid appearance and joint hypermobility syndrome. Men with CTD had lower BMI values, more severe performance anxiety, asthenia, autonomic disorders, joints pain, back pain and heart pain.Обследовали 118 мужчин 18—25 лет, военнослужащих по призыву, которые на момент исследования не имели острых заболеваний. Определяли внешние признаки ДСТ и диагностировали фенотипы НДСТ на основании современных российских рекомендаций. НДСТ выявлена у 62,7%. Чаще других регистрировался неклассифицируемый фенотип, марфаноидная внешность и синдром гипермобильности суставов. Мужчины с НДСТ отличались меньшими значениями ИМТ, более выраженными показателями тревоги, астении, вегетативных нарушений, болями в суставах, спине и сердце

Results of the Triennial Monitoring over the Ship’s Ballast Water at the Ports of the Rostov-Region

Demonstrated are the results of microbiological monitoring over the ship’s ballast water at the sea ports of the Rostov region. Analyzed for the presence of Vibrio cholerae are the samples of the ship’s ballast water collected within the period of May-September 2010-2012, a total of 179 samples collected from 127 ships. Among 30 V. cholerae non O1/ non O139 strains isolated in 2010-2011 only 13 have been identified serologically. Application of MALDI-TOF mass spectrometry in 2012 has enhanced informational capacity of the investigations. It has expanded the range and increased the frequency of bacteriological findings. The detection of vibrios implies possibility of V. cholerae importation into the aquatic area of Azov Sea

Correct quantum chemistry in a minimal basis from effective Hamiltonians

We describe how to create ab-initio effective Hamiltonians that qualitatively describe correct chemistry even when used with a minimal basis. The Hamiltonians are obtained by folding correlation down from a large parent basis into a small, or minimal, target basis, using the machinery of canonical transformations. We demonstrate the quality of these effective Hamiltonians to correctly capture a wide range of excited states in water, nitrogen, and ethylene, and to describe ground and excited state bond-breaking in nitrogen and the chromium dimer, all in small or minimal basis sets

The introduction of modern educational technologies of discipline «Life safety, emergency medicine»

One of the most acute problems of the Russian higher education system is the real transition from the «knowledge» to the practice-oriented approach. The solution to this problem affects not only the content, but also the technological aspects of the educational process. Among the latter, the technologies of formation of students‘ competences are especially important. For realization of cognitive and educational activity of students in educational process the modern educational technologies giving the chance to improve quality of education are used, more effectively to use classroom time.Одной из острейших проблем системы российского высшего образования является переход парадигмы от «знаниевого» к практико-ориентированному. Решение этой проблемы затрагивает не только содержательные, но и технологические аспекты образовательного процесса. Среди последних особенно важны технологии формирования компетенций обучающихся. Для реализации познавательной и учебной активности студентов используются современные образовательные технологии, позволяющие повышать качество образования, более эффективно использовать аудиторное время

Исследование влияния краткосрочных силовых тренировок на соревновательные результаты элитных дзюдоистов

Sports performance of elite judo athletes is dependent on the high level of technical skills and physical fitness, including strength capacities: power, muscular strength, muscular endurance and other. This study investigated the effects of short-term (4-/6- or 8-week) specific strength interventions on sports performance in male elite judokas. Thirty six elite male judokas (aged 18–22 years) practiced in short-term (4-/6- or 8-week) strength training intervention added to the regular judo training. To determine sports performance, all athletes were evaluated with regards to their performance during the five judo tournaments within three months in post-intervention. The judokas’ individual sport performance was evaluated in accordance with guidelines of the German potential analysis system (PotAS). There were significant (p≤0.05) differences in sports performance points among the groups in the first judo tournament in favor of judokas, who practiced 4-week strength training intervention. All judokas demonstrated similar mean sports performance points during the second and third judo tournaments. There were significant (p≤0.05) differences in sports performance points in favor of judokas, who practiced 6- or 8-week strength training intervention during the fourth and fifth judo tournaments. The short-term (4-/6- or 8-week) strength training interventions are not equally effective to increase sports performance of elite male judokas within three months in post- strength intervention. The final decision for the specific duration (4-/6- or 8-week) of strength training intervention can be decided according to an judoka’s medal challenges during the competition season: high sports performance in near future (during the month) or an increase in sports performance after one-two monthsСпортивные результаты элитных дзюдоистов зависят от высокого уровня технических навыков и физической подготовки, включая силовые показатели: мощность, мышечную силу, выносливость и др. В данном исследовании изучалось влияние краткосрочных (4-6 или 8 недель) специальных силовых тренировок на спортивные результаты у мужчин-дзюдоистов. Тридцать шесть элитных дзюдоистов-мужчин (в возрасте 18–22 лет) использовали краткосрочные (4-6 или 8 недель) силовые тренировки дополнительно к регулярным тренировкам по дзюдо. Для определения влияния на спортивные результаты все спортсмены были оценены в отношении их выступления во время пяти турниров по дзюдо в течение трех месяцев после окончания силовых тренировок. Индивидуальные спортивные результаты дзюдоистов оценивались в соответствии с руководящими принципами немецкой системы анализа потенциала (PotAS). На первом турнире по дзюдо были выявлены достоверные (р < 0,05) различия в спортивных результатах в пользу дзюдоистов, которые использовали 4-недельные силовые тренировки. Все исследуемые спортсмены продемонстрировали одинаковые спортивные результаты во время второго и третьего турниров. Выявлены достоверные (р < 0,05) различия в спортивных результатах в пользу дзюдоистов, которые практиковали 6- или 8-недельные силовые тренировки во время четвертого и пятого турниров по дзюдо. Установлено, что краткосрочные (4-6 или 8 недель) силовые тренировки не будут одинаково эффективными для повышения уровня спортивных результатов элитных дзюдоистов-мужчин в течение трех месяцев после их применения. Окончательное решение на использование определенной (4-6 или 8 недель) силовой тренировки может быть принято в соответствии с медальными задачами дзюдоиста в течение соревновательного сезона: высокие спортивные результаты в ближайшем будущем (в течение месяца) или увеличение уровня спортивных результатов через один-два месяц

Evidence for Involvement of Th17 Type Responses in Post Kala Azar Dermal Leishmaniasis (PKDL)

Post kala azar dermal leishamniasis (PKDL), an unusual dermatosis, develops in 5–15% of apparently cured visceral leishmaniasis cases in India and in about 60% of cases in Sudan. PKDL cases assume importance since they constitute an important human reservoir for the parasite. Host immunological responses, considered as major factors in PKDL development, are poorly understood. Limited studies have been performed to explore the host immune responses and that too, restricted to a few immune parameters. The present study employed cDNA array technique that identified various host immuno-determinants including cytokines, chemokines, apoptotic and signaling molecules which were not reported previously in PKDL. In addition, we showed for the first time that Th17 responses are present during L. donovani infection in PKDL which possibly contributes significantly to disease pathogenesis by inducing TNF-α and nitric oxide production. Our findings lead to improved understanding of the host parasite interaction in terms of immune responses and pathology in tissue lesions of PKDL

Role of IL-1 Beta in the Development of Human TH17 Cells: Lesson from NLPR3 Mutated Patients

T helper 17 cells (T(H)-17) represent a lineage of effector T cells critical in host defence and autoimmunity. In both mouse and human IL-1β has been indicated as a key cytokine for the commitment to T(H)-17 cells. Cryopyrin-associated periodic syndromes (CAPS) are a group of inflammatory diseases associated with mutations of the NLRP3 gene encoding the inflammasome component cryopyrin. In this work we asked whether the deregulated secretion of IL-1β secondary to mutations characterizing these patients could affect the IL-23/IL-17 axis.A total of 11 CAPS, 26 systemic onset juvenile idiopathic arthritis (SoJIA) patients and 20 healthy controls were analyzed. Serum levels of IL-17 and IL-6 serum were assessed by ELISA assay. Frequency of T(H)17 cells was quantified upon staphylococcus enterotoxin B (SEB) stimulation. Secretion of IL-1β, IL-23 and IL-6 by monocyte derived dendritic cells (MoDCs), were quantified by ELISA assay. A total of 8 CAPS and 11 SoJIA patients were also analysed before and after treatment with IL-1β blockade. Untreated CAPS patients showed significantly increased IL-17 serum levels as well as a higher frequency of T(H)17 compared to control subjects. On the contrary, SoJIA patients displayed a frequency of T(H)17 similar to normal donors, but were found to have significantly increased serum level of IL-6 when compared to CAPS patients or healthy donors. Remarkably, decreased IL-17 serum levels and T(H)17 frequency were observed in CAPS patients following in vivo IL-1β blockade. On the same line, MoDCs from CAPS patients exhibited enhanced secretion of IL-1β and IL-23 upon TLRs stimulation, with a reduction after anti-IL-1 treatment.These findings further support the central role of IL-1β in the differentiation of T(H)17 in human inflammatory conditions

Compatibility of measuring simple reaction time in individuals using computerized and fingertip visuomotor methods

Many studies of the reaction time (RT) expressed this index as the interval between the time of signal detection and the beginning of motor response. Reaction time is widely used in various fields of science and practice: RT assessment is an important component of health science, developmental physiology, sports medicine and can increase the thoroughness of health and clinical examinations (Bernstein, 1967; Collins et al., 2003; Henneberg et al., 2001; Kolb & Whishaw, 1995; Lovell et al.,2001; Makdissi et al.,2001; Schendel & Robertson, 2002; Warden et al.,2001). It is clear that impaired RT has functional relevance given that a rapid RT is necessary for injury avoidance and good professional skill performances. Reaction time assessment is an important component in sports medicine, especially for identification of brain concussion (Broglio & Guskiewicz, 2009; Collie et al.,2006; Collins et al.,2003). There are 2 main tests that are useful to measure reaction time. The button push reaction time test measures how quickly a participant may click (push) a button. and the fingertip visuomotor test is a procedure for conducting a reaction time test using a ruler. Advantages of computerized measurement of RT are: 1) that stimulus presentation duration is carefully controlled, 2) the period between stimuli may be easily randomized, and 3) that the time of response is easily measured (Eckner et al., 2010). Despite the advantages of computerized neuropsychological testing, it has a limited role in practice especially on the playing field (Eckner et al., 2010). Reaction time assessment tools on a computer require specialized software and specific research skills that may limit its usage. The cost of computerized testing, at $669 to$677 per person, makes them unaffordable for many low profile athletes (Grindel, 2006). It is obvious that the fingertip visuomotor field reaction time test is a very important method that is broadly used in athletic training clinics (Eckner et al., 2009; Eckner et al.,2010; Eckner & et al.,2011a,b,c). Despite of broad usage of fingertip visuomotor tests measuring RT there is little available information comparing the computerized and fingertip visuomotor methods of determining RT. In other words, the existing literature doesn’t answer the question; is the simple reaction time, tested using the simplified fingertip visuomotor method compatible with the results from the computerized methods in the same individual. We also did not find a clear answer to the question how compatible is fingertip visuomotor method selectively for the dominant and nondominant hands. The purpose of our study was to determine the individual compatibility of the simplified fingertip visuomotor method of measuring simple RT selectively for the dominant and nondominant hands of untrained healthy young people of high school age