Propuesta del sistema de evaluación de desempeño para la compañía Media Technology World Sas

La evaluación de desempeño es una herramienta de gestión que se utiliza en las organizaciones con el fin de medir el grado de eficacia con los trabajadores llevan a cabo sus tareas y responsabilidades de una manera objetiva y con el fin de medir el pulso de la operación diaria y darle a conocer al trabajador lo que la empresa espera de ellos en cada uno de sus cargos. Se quiso realizar una propuesta de evaluación de desempeño para la empresa Media Technology World SAS con el fin de conocer cuál es el grado de efectividad y eficacia de sus trabajadores en cada una de las áreas y de que más adelante puedan implementar el modelo de una manera sistemática y organizada dentro de la organización. El objetivo de realizar el estudio de la evaluación del desempeño es identificar cuáles son los beneficios que tendrá la compañía en la aplicación de la herramienta, a su vez el estudio arrojara indicadores de mejora en el proceso, se detectan cual es el mejor uso del Capital Humano, el método que se utilizo fue, la evaluación del desempeño identificando el proceso dinámico y sistemático que debe llevarse a cabo en las organizaciones con el fin de obtener información valiosa relacionada con el rendimiento de los empleados en sus puestos de trabajo Palabras claves: Desempeño, eficacia, empresa, evaluación, mejoramientoPerformance evaluation is a management tool that is used in organizations to measure the degree of efficiency with which workers conduct their tasks and responsibilities in an objective manner and to measure the pulse of the operation. daily and let the worker know what the company expects of them in each of their positions. It was wanted to conduct a performance evaluation proposal for the company Media Technology World SAS to know what the degree of effectiveness and efficiency of its workers in each of the areas and that is later they can implement the model in a more efficient way. systematic and organized within the organization. The objective of carrying out the performance evaluation is to identify excellent benefits that the company will have in the application of the tool, in turn the study will yield indicators of improvement in the process, it will be detected which is the best use of Human Capital, the method that was used was performance evaluation, identifying the dynamic and systematic process that must be carried out in organizations in order to obtain valuable information related to the performance of employees in their jobs. Keywords: Evaluation, performance, efficiency, company, improvemen

X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

WOS: 000481590200024PubMed ID: 31427717Rett syndrome (RTT) is a severe neurological disorder usually caused by mutations in the MECP2 gene. Since the MECP2 gene is located on the X chromosome, X chromosome inactivation (XCI) could play a role in the wide range of phenotypic variation of RTT patients; however, classical methylation-based protocols to evaluate XCI could not determine whether the preferentially inactivated X chromosome carried the mutant or the wild-type allele. Therefore, we developed an allele-specific methylation-based assay to evaluate methylation at the loci of several recurrent MECP2 mutations. We analyzed the XCI patterns in the blood of 174 RTT patients, but we did not find a clear correlation between XCI and the clinical presentation. We also compared XCI in blood and brain cortex samples of two patients and found differences between XCI patterns in these tissues. However, RTT mainly being a neurological disease complicates the establishment of a correlation between the XCI in blood and the clinical presentation of the patients. Furthermore, we analyzed MECP2 transcript levels and found differences from the expected levels according to XCI. Many factors other than XCI could affect the RTT phenotype, which in combination could influence the clinical presentation of RTT patients to a greater extent than slight variations in the XCI pattern.Spanish Ministry of Health (Instituto de Salud Carlos III/FEDER) [PI15/01159]; Crowdfunding program PRECIPITA, from the Spanish Ministry of Health (Fundacion Espanola para la Ciencia y la Tecnologia); Catalan Association for Rett Syndrome; Fondobiorett; Mi Princesa RettWe thank all patients and their families who contributed to this study. The work was supported by grants from the Spanish Ministry of Health (Instituto de Salud Carlos III/FEDER, PI15/01159); Crowdfunding program PRECIPITA, from the Spanish Ministry of Health (Fundacion Espanola para la Ciencia y la Tecnologia); the Catalan Association for Rett Syndrome; Fondobiorett and Mi Princesa Rett

Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries

Background Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks. Methods The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned. Results A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31). Conclusion Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)