3,133 research outputs found
Uncertainty in water transit time estimation with StorAge Selection functions and tracer data interpolation
Transit time distributions (TTDs) of streamflow are useful descriptors for understanding flow and solute transport in catchments. Catchment-scale TTDs can be modeled using tracer data (e.g. oxygen isotopes, such as δ18O) in inflow and outflows by employing StorAge Selection (SAS) functions. However, tracer data are often sparse in space and time, so they need to be interpolated to increase their spatiotemporal resolution. Moreover, SAS functions can be parameterized with different forms, but there is no general agreement on which one should be used. Both of these aspects induce uncertainty in the simulated TTDs, and the individual uncertainty sources as well as their combined effect have not been fully investigated. This study provides a comprehensive analysis of the TTD uncertainty resulting from 12 model setups obtained by combining different interpolation schemes for δ18O in precipitation and distinct SAS functions. For each model setup, we found behavioral solutions with satisfactory model performance for in-stream δ18O (KGEĝ€¯>ĝ€¯0.55, where KGE refers to the Kling-Gupta efficiency). Differences in KGE values were statistically significant, thereby showing the relevance of the chosen setup for simulating TTDs. We found a large uncertainty in the simulated TTDs, represented by a large range of variability in the 95ĝ€¯% confidence interval of the median transit time, varying at the most by between 259 and 1009ĝ€¯d across all tested setups. Uncertainty in TTDs was mainly associated with the temporal interpolation of δ18O in precipitation, the choice between time-variant and time-invariant SAS functions, flow conditions, and the use of nonspatially interpolated δ18O in precipitation. We discuss the implications of these results for the SAS framework, uncertainty characterization in TTD-based models, and the influence of the uncertainty for water quality and quantity studies
Knowledge, Attitudes and Beliefs That May Influence Infant Feeding Practices in American Indian Mothers
The promotion of healthy infant feeding is increasingly recognized as an important obesity
prevention strategy. This is relevant for American Indian (AI) populations, who exhibit high levels
of obesity and low compliance with infant feeding guidelines. The literature examining the
knowledge, attitudes and beliefs (KAB) surrounding infant feeding within the AI population is
sparse and focuses primarily on breastfeeding, with limited information on the introduction of solid foods and related practices that may be important in an obesity prevention context. This
research presents descriptive findings from a baseline KAB questionnaire on infant feeding and
related behaviors, administered to mothers (n=438) from five Northwest AI tribes that participated
in the Prevention of Toddler Overweight and Teeth Health Study (PTOTS). Enrollment occurred
during pregnancy or up to 6 months postpartum. The KAB questionnaire focused on themes of
Breastfeeding/Formula Feeding and Introducing Solid Foods, with supplemental questions on
Physical Activity. Knowledge questions were multiple-choice or true/false. Attitudes and beliefs
were assessed on Likert scales. Descriptive statistics included frequencies and percents, and means
and standard deviations. Most women knew basic breastfeeding recommendations and facts, but
fewer recognized the broader health benefits of breastfeeding (e.g., reducing diabetes risk), or
knew when to introduce solid foods. Women believed breastfeeding to be healthy and perceived
their social networks to agree. Attitudes and beliefs about formula feeding and social support were
more ambivalent. This work suggests opportunities to increase the perceived value of
breastfeeding to include broader health benefits, increase knowledge about solid foods, and
strengthen social support
TRPC1 participates in the HSV-1 infection process by facilitating viral entry
Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1-induced Ca2+ release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca2+ entry or knockdown of these proteins attenuated viral entry and infection. HSV-1 glycoprotein D interacted with the third ectodomain of TRPC1, and this interaction facilitated viral entry. Knockout of TRPC1 attenuated HSV-1-induced ocular abnormality and morbidity in vivo in TRPC1−/− mice. There was a strong correlation between HSV-1 infection and plasma membrane localization of TRPC1 in epithelial cells within oral lesions in buccal biopsies from HSV-1-infected patients. Together, our findings demonstrate a critical role for TRPC1 in HSV-1 infection and suggest the channel as a potential target for anti-HSV therapy.Fil: He, DongXu. Jiangnan University; ChinaFil: Mao, AiQin. Jiangnan University; ChinaFil: Li, YouRan. Jiangnan University; ChinaFil: Tam, SiuCheung. Chinese University Of Hong Kong; Hong KongFil: Zheng, YongTang. Kunming Institute Of Zoology Chinese Academy Of Sciences; ChinaFil: Yao, XiaoQiang. Chinese University Of Hong Kong; Hong KongFil: Birnbaumer, Lutz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; ArgentinaFil: Ambudkar, Indu S.. National Institute Of Dental And Craniofacial Research ; Estados UnidosFil: Ma, Xin. Jiangnan University; Chin
Evaluating the added value of young water fractions for determining water transit times in diverse catchments
Water transit time distributions (TTDs) are important descriptors of hydrological functioning and solute mobilization in catchments. The use of transport models based on StorAge Selection (SAS) functions is promising for characterizing non-stationary TTDs. Model parameters are typically calibrated using tracer concentration in inflow (e.g., precipitation) and outflow (e.g., streamflow) in order to obtain suitable values of SAS function parameters and, thereby, simulate TTDs at catchment-scale. However, due to uncertainties in tracer data and equifinality problems in SAS modelling, modeled TTDs can be subject to considerable uncertainty. Therefore, we need alternative and independent methods that can help constrain model parameters. An example is the young water fraction (Fyw), which quantifies the proportion of catchment outflow younger than approximately 2–3 months. Our work attempts to explore the robustness of Fyw in constraining SAS model parameter values and, in turn, reducing predictive uncertainty of TTDs in multiple contrasting sub-catchments in the Central European Bode River Basin. We simulated TTDs using sparse (i.e., monthly) stable water isotope data (δ¹⁸O) in streamflow for calibration in an experimental SAS modelling framework. In a subsequent step, we directly compared the model estimates of long-term average (marginal) TTDs with Fyw derived from the seasonal cycles of δ¹⁸O measured in precipitation and streamflow. Our results showcase if and to what extent Fyw is a valuable additional constraint to infer SAS parametrizations as well as improve TTD predictions and the characterization of water age selection dynamics, and identify potentials and gaps in isotope-based TTD models. Our results also show how the effectiveness of Fyw in reducing the predictive uncertainty of TTDs may depend on the water use by plants and land use change across physiographically different sub-catchments. Overall, as the relevance of Fyw in TTD modeling is not yet well established, our aim is to investigate whether additional indicators such as Fyw are useful for TTD modeling and thus allow improving the description of flow and transport in catchment areas, especially in situations where a high-resolution tracer data are lacking
Towards Application of StorAge Selection Functions in Large-Scale Catchments with Heterogeneous Travel Times and Subsurface Reactivity
StorAge Selection (SAS) functions describe how a catchment selectively removes water and solute of different ages via discharge, thus controlling transit time distributions (TTDs) and solute composition of discharge. Previous studies have successfully applied SAS functions in a spatially lumped approach to capture catchment-scale transport phenomena of (non-)conservative solutes. The lumped approach assumes that water and solutes within a water parcel of a specific age are well-mixed. While this assumption does not cause any changes in the age of water, the spatial heterogeneity of solute concentrations within this water parcel is lost. In addition, in large catchments, headwater sub-catchments and lowland sub-catchments could behave in different ways, e.g., the transit times (TTs) and reaction rates between headwater and lowland sub-catchment could be of different magnitudes. This, in turn, might not be sufficiently represented in a lumped approach of SAS functions. In this study, we applied the mHM-SAS model (Nguyen et al., 2020) with a semi-distributed approach of SAS functions. The nested mesoscale catchment (Selke catchment, Germany) with heterogeneous land use management practices, TTs, and subsurface reactivity was used as a case study. In addition to spatial variability, a functional relationship between the parameters of the SAS functions and storage dynamics was introduced to capture temporal dynamics of the selection preference for discharge. High frequency instream nitrate data were used to validate the proposed approach. Results show that the proposed approach can well represent nitrate export at both sub-catchment and catchment levels. The model reveals that catchment nitrate export is controlled by (1) the headwater sub-catchment with fast TTs and a high denitrification rate, and (2) the lowland sub-catchment with longer TTs and a low denitrification rate. In general, the proposed approach serves as a promising tool for understanding the interplay of transport and reaction times between different sub-catchments, which controls nitrate export in a mesoscale heterogeneous catchment
A Community-Based Intervention to Prevent Obesity Beginning at Birth among American Indian Children: Study Design and Rationale for the PTOTS study
Eating and physical activity behaviors associated with adult obesity have early antecedents, yet few studies have focused on obesity prevention interventions targeting very young children. Efforts to prevent obesity beginning at birth seem particularly important in populations at risk for early-onset obesity. National estimates indicate that American Indian (AI) children have higher rates of overweight and obesity than children of other races/ethnicities. The Prevention of Toddler Obesity and Teeth Health Study (PTOTS) is a community-partnered randomized controlled trial designed to prevent obesity beginning at birth in AI children. PTOTS was developed to test the effectiveness of a multi-component intervention designed to: promote breastfeeding, reduce sugar-sweetened beverage consumption, appropriately time the introduction of healthy solid foods, and counsel parents to reduce sedentary lifestyles in their children. A birth cohort of 577 children from five AI tribes is randomized by tribe to either the intervention (three tribes) or the comparison condition (two tribes). The strengths and weaknesses of PTOTS include a focus on a critical growth phase, placement in the community, and intervention at many levels, using a variety of approaches
Droughts can reduce the nitrogen retention capacity of catchments
In 2018-2019, Central Europe experienced an unprecedented 2-year drought with severe impacts on society and ecosystems. In this study, we analyzed the impact of this drought on water quality by comparing long-Term (1997-2017) nitrate export with 2018-2019 export in a heterogeneous mesoscale catchment. We combined data-driven analysis with process-based modeling to analyze nitrogen retention and the underlying mechanisms in the soils and during subsurface transport. We found a drought-induced shift in concentration-discharge relationships, reflecting exceptionally low riverine nitrate concentrations during dry periods and exceptionally high concentrations during subsequent wet periods. Nitrate loads were up to 73ĝ€¯% higher compared to the long-Term load-discharge relationship. Model simulations confirmed that this increase was driven by decreased denitrification and plant uptake and subsequent flushing of accumulated nitrogen during rewetting. Fast transit times (20 years) inhibited a fast response but potentially contribute to a long-Term drought legacy. Overall, our study reveals that severe droughts, which are predicted to become more frequent across Europe, can reduce the nitrogen retention capacity of catchments, thereby intensifying nitrate pollution and threatening water quality
Disparate Seasonal Nitrate Export from Nested Heterogeneous Subcatchments Revealed with StorAge Selection Functions
Understanding catchment controls on catchment solute export is a prerequisite for water quality management. StorAge Selection (SAS) functions encapsulate essential information about catchment functioning in terms of discharge selection preference and solute export dynamics. However, they lack information on the spatial origin of solutes when applied at the catchment scale, thereby limiting our understanding of the internal (subcatchment) functioning. Here, we parameterized SAS functions in a spatially explicit way to understand the internal catchment responses and transport dynamics of reactive dissolved nitrate (N-NO<sub>3</sub>). The model was applied in a nested mesoscale catchment (457 km²), consisting of a mountainous partly forested, partly agricultural subcatchment, a middle-reach forested subcatchment, and a lowland agricultural subcatchment. The model captured flow and nitrate concentration dynamics not only at the catchment outlet but also at internal gauging stations. Results reveal disparate subsurface mixing dynamics and nitrate export among headwater and lowland subcatchments. The headwater subcatchment has high seasonal variation in subsurface mixing schemes and younger water in discharge, while the lowland subcatchment has less pronounced seasonality in subsurface mixing and much older water in discharge. Consequently, nitrate concentration in discharge from the headwater subcatchment shows strong seasonality, whereas that from the lowland subcatchment is stable in time. The temporally varying responses of headwater and lowland subcatchments alternates the dominant contribution to nitrate export in high and low-flow periods between subcatchments. Overall, our results demonstrate that the spatially explicit SAS modeling provides useful information about internal catchment functioning, helping to develop or evaluate spatial management practices
Nitrogen transport and retention dynamics across central European catchments using large-sample data
Human activities, especially agricultural practices, have significantly altered the Earth’s landscape and the global cycle of nitrogen. In Europe, diffuse nitrogen (N) input from agriculture has been identified as a major driver of marine eutrophication. Despite a long history of measures, little improvement in groundwater and surface water quality has been observed. Recent studies have attempted to provide insights into nitrogen dynamics at the catchment scale, helping to explain the causes and effects of persistent water quality problems. However, there is a lack of large-scale, long-term studies that provide insights into both biogeochemical and hydrological N legacies under different landscape settings. Here using data of more than 100 German catchments of the last seven decades, we synthesis the nitrogen transport and retention dynamics, as well as their dominant (landscape and climate) controls in a large-sample setting. To this end, we adapted the mHM-SAS model (Nguyen et al., 2021) to reflect regional-scale biogeochemical and hydrological N legacies, taking into account the historical development of both diffuse and point sources. The underlying parameterizations were constrained using instream N concentrations. We found high heterogeneity in catchment responses to N inputs. The fractions of N surplus that were stored in the soil, removed by denitrification, stored in the subsurface, and finally exported to the stream vary over a wide range. Our analysis of the long-term (1950-2014) average N balances from all catchments suggests that a majority (mean = 57%) of N surplus was removed by denitrification, followed by stream N export (27%) and the rest was stored in the catchment (16%). Despite the reduction in N surplus after 1990s, biogeochemical legacy reflected in the soil N build-up showed an increasing trend over the analyzed period (1950-2014) across a majority of the study catchments. As for the hydrologic legacy, we found a varying range of mean transit times of discharge between 3.5 years and 13.1 years (95% confidence interval) among the analyzed catchments. Overall, our large-sample analysis provides a detailed overview of biogeochemical and hydrological N legacies across Germany; and thus provides useful insights for an improvement of agricultural practices and water quality management in Central European landscapes
Droughts can reduce the nitrogen retention capacity of catchments
In 2018–2019, Central Europe experienced an unprecedented multi-year drought with severe impacts on society and ecosystems. In this study, we analyzed the impact of this drought on water quality by comparing long-term (1997-2017) nitrate export with 2018–2019 export in a heterogeneous mesoscale catchment. We combined data-driven analysis with process-based modelling to analyze nitrogen retention and the underlying mechanisms in the soils and during subsurface transport. We found a drought-induced shift in concentration-discharge relationships, reflecting exceptionally low riverine nitrate concentrations during dry periods and exceptionally high concentrations during subsequent wet periods. Nitrate loads were up to 70% higher compared to the long-term load-discharge relationship. Model simulations confirmed that this increase was driven by decreased denitrification and plant uptake and subsequent flushing of accumulated nitrogen during rewetting. Fast transit times (20 years) inhibited a fast response but potentially contribute to a long-term drought legacy. Overall, our study reveals that severe multi-year droughts, which are predicted to become more frequent across Europe, can reduce the nitrogen retention capacity of catchments, thereby intensifying nitrate pollution and threatening water quality
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