Particularities of spatial kinetics of hybrid thorium reactor installation containing the long neutron source based on magnetic trap

In this work, we study the features of the spatial kinetics of installation as a hybrid thorium reactor with an elongated plasma neutron source based on a magnetic trap. The active zone of the installation under study consists of an assembly of hexagonal fuel blocks of a unified design and a long solenoid with a high-temperature plasma column passing through the axial region of the core. Combining engineering expertise in creating nuclear reactors with a physics-technical potential for obtaining high-temperature plasma in a long magnetic trap we ensure the solution of the multidisciplinary problem posed. These studies are of undoubted practical interest, since they are necessary to substantiate the safety of operation of such hybrid systems. The research results will allow optimizing the active zone of the hybrid system with leveling the resulting offset radial and axial energy release distributions. Results of our study will be the basis for the development of new and improvement of existing methods of criticality control in related systems such as "pulsed neutron source - subcritical fuel assembly"

Statistical and integrative system-level analysis of DNA methylation data

Epigenetics plays a key role in cellular development and function. Alterations to the epigenome are thought to capture and mediate the effects of genetic and environmental risk factors on complex disease. Currently, DNA methylation is the only epigenetic mark that can be measured reliably and genome-wide in large numbers of samples. This Review discusses some of the key statistical challenges and algorithms associated with drawing inferences from DNA methylation data, including cell-type heterogeneity, feature selection, reverse causation and system-level analyses that require integration with other data types such as gene expression, genotype, transcription factor binding and other epigenetic information

Prediction of Possible Scenarios for the Development of the Ukrainian Economy in the Context of A “Hybrid” War the Russian Federation

In the article identifies that in modern military conflicts have emphasis is shifting towards a comprehensive application of political, economic, informational and other non-military measures. It was noted that for achieve the objectives in the “hybrid” war – the economic sphere is an important operating space and a key non-military mechanism for the preparation and realization of aggression. It was found that for maximum attenuation in the “non-contact” economic potential enemy state, the use of economic instruments in combination with other non-military levers can significantly minimize the use of armed arsenal of the aggressor country. In the article selected research object, the object of the conflict and stakeholders. The purpose of the article was to predict the four scenarios of development of the Ukrainian economy and the probability of their achievements along 2020-2035 years, based on the selected baseline scenario. For the formation of the main components of the baseline scenario were analyzed strengths and weaknesses of the internal factors of the economy in view of the major contributing factors, and direct and indirect losses from the warfare of the Russian Federation (RF) in the east of Ukraine and the Autonomous Republic of Crimea. They were analyzed by external economic threats, focusing on the monopoly of economic dependence of Ukraine from Russian markets. As a result, it was revealed the main trends and the key factors that have the largest share of influence on forecasting of economic conflict. Based on this analysis defines the main axis with the extrema, the most affecting on the object of investigation. Based on the method of scenario planning predicted four possible scenarios of economic development of Ukraine for the next 15 years, the strengths and weaknesses of each simulated scenario. The probabilities of accomplishing the desired, not desired, probable and least probable scenarios are determined