1 research outputs found
PORTEC-4a: International randomized trial of molecular profile-based adjuvant treatment for women with high-intermediate risk endometrial cancer
Background Vaginal brachytherapy is currently
recommended as adjuvant treatment in patients with highintermediate risk endometrial cancer to maximize local
control and has only mild side effects and no or limited
impact on quality of life. However, there is still considerable
overtreatment and also some undertreatment, which
may be reduced by tailoring adjuvant treatment to the
patients’ risk of recurrence based on molecular tumor
characteristics.
Primary objectives To compare the rates of vaginal
recurrence in women with high-intermediate risk
endometrial cancer, treated after surgery with molecularintegrated risk profile-based recommendations for either
observation, vaginal brachytherapy or external pelvic
beam radiotherapy or with standard adjuvant vaginal
brachytherapy
Study hypothesis Adjuvant treatment based on a
molecular-integrated risk profile provides similar local
control and recurrence-free survival as current standard
adjuvant brachytherapy in patients with high-intermediate
risk endometrial cancer, while sparing many patients the
morbidity of adjuvant t