2,727 research outputs found
A Deep Cascade of Convolutional Neural Networks for MR Image Reconstruction
The acquisition of Magnetic Resonance Imaging (MRI) is inherently slow.
Inspired by recent advances in deep learning, we propose a framework for
reconstructing MR images from undersampled data using a deep cascade of
convolutional neural networks to accelerate the data acquisition process. We
show that for Cartesian undersampling of 2D cardiac MR images, the proposed
method outperforms the state-of-the-art compressed sensing approaches, such as
dictionary learning-based MRI (DLMRI) reconstruction, in terms of
reconstruction error, perceptual quality and reconstruction speed for both
3-fold and 6-fold undersampling. Compared to DLMRI, the error produced by the
method proposed is approximately twice as small, allowing to preserve
anatomical structures more faithfully. Using our method, each image can be
reconstructed in 23 ms, which is fast enough to enable real-time applications
Challenges to estimating vaccine impact using hospitalization data.
Because the real-world impact of new vaccines cannot be known before they are implemented in national programs, post-implementation studies at the population level are critical. Studies based on analysis of hospitalization rates of vaccine-preventable outcomes are typically used for this purpose. However, estimates of vaccine impact based on hospitalization data are particularly prone to confounding, as hospitalization rates are tightly linked to changes in the quality, access and use of the healthcare system, which often occur simultaneously with introduction of new vaccines. Here we illustrate how changes in healthcare delivery coincident with vaccine introduction can influence estimates of vaccine impact, using as an example reductions in infant pneumonia hospitalizations after introduction of the 10-valent pneumococcal conjugate vaccine (PCV10) in Brazil. To this end, we explore the effect of changes in several metrics of quality and access to public healthcare on trends in hospitalization rates before (2008-09) and after (2011-12) PCV10 introduction in 2010. Changes in infant pneumonia hospitalization rates following vaccine introduction were significantly associated with concomitant changes in hospital capacity and the fraction of the population using public hospitals. Importantly, reduction of pneumonia hospitalization rates after PCV10 were also associated with the expansion of outpatient services in several Brazilian states, falling more sharply where primary care coverage and the number of health units offering basic and emergency care increased more. We show that adjustments for unrelated (non-vaccine) trends commonly employed by impact studies, such as use of single control outcomes, are not always sufficient for accurate impact assessment. We discuss several ways to identify and overcome such biases, including sensitivity analyses using different denominators to calculate hospitalizations rates and methods that track changes in the outpatient setting. Employing these practices can improve the accuracy of vaccine impact estimates, particularly in evolving healthcare settings typical of low- and middle-income countries
Untersuchungen zur Ermittlung der Bruchzähigkeit an Laubholz in den Rissöffnungsmodi I und II
Zusammenfassung: Es werden die Ergebnisse zur Bestimmung der Bruchzähigkeit an Buche (Fagus silvatica L.) und Eiche (Quercus Robur L.) sowie Buche im Mode II vorgestellt. Verwendung fand die Kompaktzugprobe (CT-Probe) für Mode I und die CTS Probe für Mode II. Es werden Ergebnisse für den Einfluss von Holzfeuchte, Rohdichte und Jahrringlage vorgestellt. Zusätzlich wurden die Schallemissionen beim Bruch aufgezeichnet und REM-Aufnahmen angefertigt. Ergänzend zu den Bruchzähigkeiten werden verschiedenen Ansätze für Bruchgrenzkurven untersucht. Die Ergebnisse für Modus I stimmen gut mit denen aus der Untersuchung an der CT-Probe überein. Weiterhin werden verschiedene Ansätze zu Bruchgrenzkurven diskutiert und mit den experimentellen Ergebnissen vergliche
How well-proportioned are lens and prism spaces?
The CMB anisotropies in spherical 3-spaces with a non-trivial topology are
analysed with a focus on lens and prism shaped fundamental cells. The
conjecture is tested that well proportioned spaces lead to a suppression of
large-scale anisotropies according to the observed cosmic microwave background
(CMB). The focus is put on lens spaces L(p,q) which are supposed to be oddly
proportioned. However, there are inhomogeneous lens spaces whose shape of the
Voronoi domain depends on the position of the observer within the manifold.
Such manifolds possess no fixed measure of well-proportioned and allow a
predestined test of the well-proportioned conjecture. Topologies having the
same Voronoi domain are shown to possess distinct CMB statistics which thus
provide a counter-example to the well-proportioned conjecture. The CMB
properties are analysed in terms of cyclic subgroups Z_p, and new point of view
for the superior behaviour of the Poincar\'e dodecahedron is found
Impact of Pneumococcal Conjugate Vaccines on Pneumonia Hospitalizations in High- and Low-Income Subpopulations in Brazil.
BackgroundPneumococcal conjugate vaccines (PCVs) are being used worldwide. A key question is whether the impact of PCVs on pneumonia is similar in low- and high-income populations. However, most low-income countries, where the burden of disease is greatest, lack reliable data that can be used to evaluate the impact. Data from middle-income countries that have both low- and high-income subpopulations can provide a proxy measure for the impact of the vaccine in low-income countries.MethodsWe evaluated the impact of PCV10 on hospitalizations for all-cause pneumonia in Brazil, a middle-income country with localities that span a broad range of human development index (HDI) levels. We used complementary time series and spatiotemporal methods (synthetic controls and hierarchical Bayesian spatial regression) to test whether the decline in pneumonia hospitalizations associated with vaccine introduction varied across the socioeconomic spectrum.ResultsWe found that the declines in all-cause pneumonia hospitalizations in children and young and middle-aged adults did not vary substantially across low and high HDI subpopulations. Moreover, the estimated declines seen in infants and young adults were associated with higher levels of uptake of the vaccine at a local level.ConclusionsThese results suggest that PCVs have an important impact on hospitalizations for all-cause pneumonia in both low- and high-income populations
Long-Term Variations in the Growth and Decay Rates of Sunspot Groups
Using the combined Greenwich (1874-1976) and Solar Optical Observatories
Network (1977-2009) data on sunspot groups, we study the long-term variations
in the mean daily rates of growth and decay of sunspot groups. We find that the
minimum and the maximum values of the annually averaged daily mean growth rates
are ~52% per day and ~183% per day, respectively, whereas the corresponding
values of the annually averaged daily mean decay rates are ~21% per day and
~44% per day, respectively. The average value (over the period 1874-2009) of
the growth rate is about 70% more than that of the decay rate. The growth and
the decay rates vary by about 35% and 13%, respectively, on a 60-year
time-scale. From the beginning of Cycle 23 the growth rate is substantially
decreased and near the end (2007-2008) the growth rate is lowest in the past
about 100 years.Comment: 1 table, 13 figures, accepted by Solar Physic
Cosmic Topology of Polyhedral Double-Action Manifolds
A special class of non-trivial topologies of the spherical space S^3 is
investigated with respect to their cosmic microwave background (CMB)
anisotropies. The observed correlations of the anisotropies on the CMB sky
possess on large separation angles surprising low amplitudes which might be
naturally be explained by models of the Universe having a multiconnected
spatial space. We analysed in CQG 29(2012)215005 the CMB properties of prism
double-action manifolds that are generated by a binary dihedral group D^*_p and
a cyclic group Z_n up to a group order of 180. Here we extend the CMB analysis
to polyhedral double-action manifolds which are generated by the three binary
polyhedral groups (T^*, O^*, I^*) and a cyclic group Z_n up to a group order of
1000. There are 20 such polyhedral double-action manifolds. Some of them turn
out to have even lower CMB correlations on large angles than the Poincare
dodecahedron
Feasibility and performances of compressed-sensing and sparse map-making with Herschel/PACS data
The Herschel Space Observatory of ESA was launched in May 2009 and is in
operation since. From its distant orbit around L2 it needs to transmit a huge
quantity of information through a very limited bandwidth. This is especially
true for the PACS imaging camera which needs to compress its data far more than
what can be achieved with lossless compression. This is currently solved by
including lossy averaging and rounding steps on board. Recently, a new theory
called compressed-sensing emerged from the statistics community. This theory
makes use of the sparsity of natural (or astrophysical) images to optimize the
acquisition scheme of the data needed to estimate those images. Thus, it can
lead to high compression factors.
A previous article by Bobin et al. (2008) showed how the new theory could be
applied to simulated Herschel/PACS data to solve the compression requirement of
the instrument. In this article, we show that compressed-sensing theory can
indeed be successfully applied to actual Herschel/PACS data and give
significant improvements over the standard pipeline. In order to fully use the
redundancy present in the data, we perform full sky map estimation and
decompression at the same time, which cannot be done in most other compression
methods. We also demonstrate that the various artifacts affecting the data
(pink noise, glitches, whose behavior is a priori not well compatible with
compressed-sensing) can be handled as well in this new framework. Finally, we
make a comparison between the methods from the compressed-sensing scheme and
data acquired with the standard compression scheme. We discuss improvements
that can be made on ground for the creation of sky maps from the data.Comment: 11 pages, 6 figures, 5 tables, peer-reviewed articl
Cosmic microwave anisotropies in an inhomogeneous compact flat universe
The anisotropies of the cosmic microwave background (CMB) are computed for
the half-turn space E_2 which represents a compact flat model of the Universe,
i.e. one with finite volume. This model is inhomogeneous in the sense that the
statistical properties of the CMB depend on the position of the observer within
the fundamental cell. It is shown that the half-turn space describes the
observed CMB anisotropies on large scales better than the concordance model
with infinite volume. For most observer positions it matches the temperature
correlation function even slightly better than the well studied 3-torus
topology
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