315 research outputs found
Spin-orbit coupling and the conservation of angular momentum
In nonrelativistic quantum mechanics, the total (i.e. orbital plus spin)
angular momentum of a charged particle with spin that moves in a Coulomb plus
spin-orbit-coupling potential is conserved. In a classical nonrelativistic
treatment of this problem, in which the Lagrange equations determine the
orbital motion and the Thomas equation yields the rate of change of the spin,
the particle's total angular momentum in which the orbital angular momentum is
defined in terms of the kinetic momentum is generally not conserved. However, a
generalized total angular momentum, in which the orbital part is defined in
terms of the canonical momentum, is conserved. This illustrates the fact that
the quantum-mechanical operator of momentum corresponds to the canonical
momentum of classical mechanics.Comment: 10 pages, as published by Eur. J. Phy
The CRESST Dark Matter Search
The current status of CRESST (Cryogenic Rare Event Search using
Superconducting Thermometers) and new results concerning the detector
development are presented. The basic technique of CRESST is to search for
particle Dark Matter (WIMPS, Weakly Interacting Massive particles) by the
measurement of non-thermal phonons as created by WIMP-induced nuclear recoils.
Combined with the newly developed method of simultaneous measurement of
scintillation light, strong background discrimination is possible, resulting in
a substantial increase in WIMP detection sensitivity. The short and long term
perspectives of CRESST are discussed.Comment: 12 pages, 6 figure
Lady Gaga as (dis)simulacrum of monstrosity
Lady Gagaâs celebrity DNA revolves around the notion of monstrosity, an extensively
researched concept in postmodern cultural studies. The analysis that is offered in this
paper is largely informed by Deleuze and Guattariâs notion of monstrosity, as well as
by their approach to the study of sign-systems that was deployed in A Thousand
Plateaus. By drawing on biographical and archival visual data, with a focus on the
relatively underexplored live show, an elucidation is afforded of what is really monstrous
about Lady Gaga. The main argument put forward is that monstrosity as sign
seeks to appropriate the horizon of unlimited semiosis as radical alterity and openness
to signifying possibilities. In this context it is held that Gaga effectively delimits her
unique semioscape; however, any claims to monstrosity are undercut by the inherent
limits of a representationalist approach in sufficiently engulfing this concept. Gaga is
monstrous for her community insofar as she demands of her fans to project their
semiosic horizon onto her as a simulacrum of infinite semiosis. However, this simulacrum
may only be evinced in a feigned manner as a (dis)simulacrum. The analysis of
imagery from seminal live shows during 2011â2012 shows that Gagaâs presumed
monstrosity is more akin to hyperdifferentiation as simultaneous employment of
heterogeneous and potentially dissonant inter pares cultural representations. The article
concludes with a problematisation of audience effects in the light of Gagaâs adoption of
a schematic and post-representationalist strategy in the event of her strategyâs emulation
by competitive artists
Illusory temporal binding in meditators
We investigate conditions in which more accurate metacognition may lead to greater susceptibility to illusion; and thus conditions under which mindfulness meditation may lead to less accurate perceptions. Specifically, greater awareness of intentions may lead to an illusory compression of time between a voluntary action and its outcome (âintentional bindingâ). Here we report that experienced Buddhist mindfulness meditators rather than non-meditators display a greater illusory shift of the timing of an outcome towards an intentional action. Mindfulness meditation involves awareness of causal connections between different mental states, including intentions. We argue that this supports improvements in metacognition targeted at motor intentions. Changes in metacognitive ability may result in an earlier and less veridical experience of the timing of action outcomes either through increased access to sensorimotor pre-representations of an action outcome or by affording greater precision to action timing judgements. Furthermore, as intentional binding is an implicit measure of the sense of agency, these results also provide evidence that mindfulness meditators experience a stronger sense of agency
Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers
Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates.
Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS.
Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS.
Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management
Time perception and the experience of agency in meditation and hypnosis
Mindfulness meditation and hypnosis are related in opposing ways to awareness of intentions. The cold control theory of hypnosis proposes that hypnotic responding involves the experience of involuntariness while performing an actually intentional action. Hypnosis therefore relies upon inaccurate metacognition about intentional actions and experiences. Mindfulness meditation centrally involves awareness of intentions and is associated with improved metacognitive access to intentions. Therefore, mindfulness meditators and highly hypnotizable people may lie at opposite ends of a spectrum with regard to metacognitive access to intentionârelated information. Here we review the theoretical background and evidence for differences in the metacognition of intentions in these groups, as revealed by chronometric measures of the awareness of voluntary action: the timing of an intention to move (Libet's âWâ judgments) and the compressed perception of time between an intentional action and its outcome (âintentional bindingâ). We review these measures and critically evaluate their proposed connection to the experience of volition and sense of agency
Effects of Fluids on the Macro- and Microcirculations.
This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901
Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
Background
Low-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.
Methods
We evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genesâ coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.
Results
In European ancestry samples, 14 genes were significantly associated (qâ
Conclusions
Using extended gene-based aggregation tests including coding and regulatory variation, we report identification of plausible target genes for previously identified single-marker associations with BC as well as the discovery of novel genes implicated in BC development. Including multi ancestral cohorts in this study enabled the identification of otherwise missed disease associations as ESR1 (Pâ=â1.31âĂâ10â5), demonstrating the importance of diversifying study cohorts
Trait phenomenological control predicts experience of mirror synaesthesia and the rubber hand illusion
In hypnotic responding, expectancies arising from imaginative suggestion drive striking experiential changes (e.g., hallucinations) â which are experienced as involuntary â according to a normally distributed and stable trait ability (hypnotisability). Such experiences can be triggered by implicit suggestion and occur outside the hypnotic context. In large sample studies (of 156, 404 and 353 participants), we report substantial relationships between hypnotisability and experimental measures of experiential change in mirror-sensory synaesthesia and the rubber hand illusion comparable to relationships between hypnotisability and individual hypnosis scale items. The control of phenomenology to meet expectancies arising from perceived task requirements can account for experiential change in psychological experiments
Evaluation of European-based polygenic risk score for breast cancer in Ashkenazi Jewish women in Israel
To date, most BC GWASs have been performed Background Polygenic risk score (PRS), calculated in individuals of European (EUR) ancestry, and based on genome-wide association studies (GWASs), the generalisation of EUR-based PRS to other can improve breast cancer (BC) risk assessment. populations is a major challenge. In this study, we examined the performance of EUR-based BC PRS models in Ashkenazi Jewish (AJ) women. Methods We generated PRSs based on data on EUR women from the Breast Cancer Association Consortium (BCAC). We tested the performance of the PRSs in a cohort of 2161 AJ women from Israel (1437 cases and 724 controls) from BCAC (BCAC cohort from Israel (BCAC-IL)). In addition, we tested the performance of these EUR-based BC PRSs, as well as the established 313-SNP EUR BC PRS, in an independent cohort of 181 AJ women from Hadassah Medical Center (HMC) in Israel. Results In the BCAC-IL cohort, the highest OR per 1 SD was 1.56 (±0.09). The OR for AJ women at the top 10% of the PRS distribution compared with the middle quintile was 2.10 (±0.24). In the HMC cohort, the OR per 1 SD of the EUR-based PRS that performed best in the BCAC-IL cohort was 1.58±0.27. The OR per 1 SD of the commonly used 313-SNP BC PRS was 1.64 (±0.28). Conclusions Extant EUR GWAS data can be used for generating PRSs that identify AJ women with markedly elevated risk of BC and therefore hold promise for improving BC risk assessment in AJ women.</p
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