Models of residential space for ethnic minorities in Thanh Hoa Province associated with sustainable livelihoods

Thanh Hoa Province has 11 mountainous districts with seven ethnic minority groups, and the three largest ethnic groups are the Muong, Thai, and H'Mong. This region has great potential for developing a forest-based economy, ecotourism, community-based tourism, and cultural heritage tourism that is associated with cultural festivals, customs, lifestyles, and traditional housing architecture. However, developing a family-based economy, such as engaging in community-based tourism or agricultural production, has negatively affected and disrupted the structure of village spaces, spatial planning, and traditional house design. The arbitrary construction of additional service spaces and spaces for resident guests within the village space and the precinct of a house has reduced the area of the garden and agricultural land. The self-initiated modification, expansion, and use of non-traditional materials in traditional housing structures by residents to serve tourists have resulted in the loss of the architectural value of traditional homes. The exploitation of agricultural land has affected the natural forest area, the forest protection area at the headwaters, and the vegetation cover and natural ecosystems. Moreover, agricultural economic activities have not been linked to service activities, handicraft production, or tourism, and there are no adaptive residential space models, thus failing to create sustainable livelihood activities. Therefore, the article proposes settlement space models and orientations for residential space development including village spaces, house precincts, and traditional housing spaces of ethnic minorities in Thanh Hoa Province, associated with sustainable livelihoods based on the exploitation of traditional housing architectural heritage values to ensure local economic development. These models are closely linked with the conservation and promotion of ethnic cultural values, landscape preservation, environmental protection, and contribution to poverty reduction for residents

Engineered Poly(L-Lactic acid) - Based Nanofibers for Osteogenic Differentiation of Human Mesenchymal Stem Cells

Ph.DDOCTOR OF PHILOSOPH

Influence of edge crack on frequencies of thin plate in bending

This paper investigates the influence of crack location and crack length on changes in natural frequencies of bending thin plate. To perform this analysis, a computing program called CRACK-PLATE, using the finite element method based on the Ressner-Mindlin' theory of plate is developed. In order to achieve a high accuracy, an isoparametric element of Barsoum is combined with an 8-node quadrilateral isoparametric element. The numerical results show that the natural frequencies are very sensitive to the crack presence in the bending thin plate. This study is a basis for crack identification based on natural frequencies of plates

Buckling of the initial imperfect rectangular thin plate with variable thickness

This paper analyzes the stability of the rectangular thin plate with sinusoidal changes in the plate thickness combined with initial curvature based on the large deflection theory. The buckling load for simply supported plates is defined using the energy method. The influence of the thickness variation parameter and the initial curvature parameter on the critical loads is investigated

OPTIMIZING THE PRODUCTION OF A FUNCTIONAL TYPE A RECOMBINANT ENDOCHITINASE FROM Trichoderma asperellum IN Escherichia coli

Chitinases from the genus Trichoderma fungi are mainly responsible for their anti-fungal activities, which allow them to become the most widely used fungal biocontrol. Therefore, several Trichoderma chitinases have been cloned and expressed to facilitate their production and applications. A previous study of the same authors has characterized an endochitinase from a relatively novel Trichoderma spp., Trichoderma asperellum. To produce this enzyme more economically and efficiently, we reported the synthesis and expression of its synthetic encoding gene in the Escherichia coli M15 strain and established the optimal conditions for preparative scale production of the enzyme in its functional form. By lowering the induction temperatures, we observed substantial improvement in the expression levels of the active enzyme.  At 30 oC and 0.5 mM IPTG induction, 1 L of cells yielded approximately 80 - 100 mg of soluble protein, accounting for about 9-11 % of total soluble protein. This figure may be an underestimation of the actual yield, as deduced from the SDS-PAGE data. The recombinant enzyme can be retrieved by simple repeated freezing and thawing cycles and purified to near homogeneity using Ni-NTA chromatography. The purified enzyme showed in vitro colloidal chitin hydrolysis activity. These results could be scaled up to produce soluble 42 kDa chitinase in E. coli. The study demonstrated an economical method to produce chitinases for various agricultural and environmental applications

Lovastatin for adult patients with dengue: protocol for a randomised controlled trial.

BACKGROUND: Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and haemorrhage. One of the hallmarks of severe dengue is vascular endothelial disruption. There is currently no specific therapy and clinical management is limited to supportive care. Statins are a class of drug initially developed for lipid lowering. There has been considerable recent interest in their effects beyond lipid lowering. These include anti-inflammatory effects at the endothelium. In addition, it is possible that lovastatin may have an anti-viral effect against dengue. Observational data suggest that the use of statins may improve outcomes for such conditions as sepsis and pneumonia. This paper describes the protocol for a randomised controlled trial investigating a short course of lovastatin therapy in adult patients with dengue. METHODS/DESIGN: A randomised, double-blind, placebo-controlled trial will investigate the effects of lovastatin therapy in the treatment of dengue. The trial will be conducted in two phases with an escalation of dose between phases if an interim safety review is satisfactory. This is an exploratory study focusing on safety and there are no data on which to base a sample size calculation. A target sample size of 300 patients in the second phase, enrolled over two dengue seasons, was chosen based on clinical judgement and feasibility considerations. In a previous randomised trial in dengue, about 10% and 30% of patients experienced at least one serious adverse event or adverse event, respectively. With 300 patients, we will have 80% power to detect an increase of 12% (from 10% to 22%) or 16% (from 30% to 46%) in the frequency of adverse events. Furthermore, this sample size ensures some power to explore the efficacy of statins. DISCUSSION: The development of a dengue therapeutic that can attenuate disease would be an enormous advance in global health. The favourable effects of statins on the endothelium, their good safety profile and their low cost make lovastatin an attractive therapeutic candidate. TRIAL REGISTRATION: International Standard Randomised Controlled Trial Number ISRCTN03147572

The impact of sustainable supply chain management practices on environmental performance of Viet-namese agricultural enterprises

The objective of the paper is to assess the impact of sustainable supply chain management practices on environmental performance of Vietnamese agricultural enterprises. The study conducted a survey of management leaders of Vietnamese agricultural enterprises. After 3 months, 328 surveys were obtained, after cleaning the data, there were 283 valid surveys for analysis. The results show that sustainable supply chain management practice has a positive impact on environmental performance and environmental regulations are not enough grounds to affirm a moderating role in the relationship between sustainable supply chain management practice and environmental performance of Vietnamese agricultural enterprises. From there, the study makes recommendations for Vietnamese agricultural enterprises

Fed-LSAE: Thwarting Poisoning Attacks against Federated Cyber Threat Detection System via Autoencoder-based Latent Space Inspection

The significant rise of security concerns in conventional centralized learning has promoted federated learning (FL) adoption in building intelligent applications without privacy breaches. In cybersecurity, the sensitive data along with the contextual information and high-quality labeling in each enterprise organization play an essential role in constructing high-performance machine learning (ML) models for detecting cyber threats. Nonetheless, the risks coming from poisoning internal adversaries against FL systems have raised discussions about designing robust anti-poisoning frameworks. Whereas defensive mechanisms in the past were based on outlier detection, recent approaches tend to be more concerned with latent space representation. In this paper, we investigate a novel robust aggregation method for FL, namely Fed-LSAE, which takes advantage of latent space representation via the penultimate layer and Autoencoder to exclude malicious clients from the training process. The experimental results on the CIC-ToN-IoT and N-BaIoT datasets confirm the feasibility of our defensive mechanism against cutting-edge poisoning attacks for developing a robust FL-based threat detector in the context of IoT. More specifically, the FL evaluation witnesses an upward trend of approximately 98% across all metrics when integrating with our Fed-LSAE defense

Smoke-free environment policy in Vietnam: What did people see and how did they react when they visited various public places?

Introduction: Since Vietnam has signed WHO framework on tobacco control (FCTC) in 2003 and has issued tobacco control law in 2013, there has been little research concerning about what impacts smoke-free regulations have had on public compliance. The objective of this study was to assess public exposure to secondhand smoke and reaction toward smoke-free policy regulations in Vietnam and the associated factor. Methods: Using the design of GATS (Global Adult Tobacco Survey), a nationally representative sample of 8,996 adults were approached for data collection. Logistic regression was used to examine the associated factor.Results: The study revealed that the prevalence of respondents exposed to secondhand smoke was much higher in bars/café/tea shops (90.07%) and restaurants (81.81%) than in any other public places, universities (36.70%), government buildings (31.12%), public transport (20.04%), healthcare facilities (17.85%) and schools (15.84%). 13.23% of respondents saw smokers violate smoke-free regulations. Among those who saw them violate smoke-free regulations, just one-third cautioned them to stop smoking. Strikingly, a higher rate of cautioning smokers to stop smoking was observed among the older, married, and better educated respondents. Respondents who were married, better educated and in lower economic status were more likely to remind smokers to stop smoking.Conclusions: The study has called for strengthening two of the six MPOWER (Monitor, Protect, Offer, Warn, Enforce and Raise) components of the tobacco free initiative introduced by WHO, Monitoring tobacco use and prevention policies and Protecting people from tobacco smoke