2019 Overview

The CNS Neuroscience & Therapeutics provides a medium for rapid publication of original clinical, experimental, and translational research papers, timely reviews, and reports of novel findings of therapeutic relevance to the central nervous system. Its focus includes clinical pharmacology, drug development, and novel methodologies for drug evaluation in neurological and psychiatric diseases. We are pleased to announce that CNS Neuroscience & Therapeutics has become an Open‐Access Journal as of January 2019. This would allow wider dissemination of scientific knowledge and facilitate collaborative efforts toward advancing novel and solid research on the maintenance of brain homeostasis and repairing the aging and dysfunctional brain

Tunable synchrotron-like radiation from centimeter scale plasma channels

Synchrotron radiation sources are immensely useful tools for scientific researches and many practical applications. Currently, the state-of-the-art synchrotrons rely on conventional accelerators, where electrons are accelerated in a straight line and radiate in bending magnets or other insertion devices. However, these facilities are usually large and costly. Here, we study a compact all-optical synchrotron like radiation source based on laser-plasma acceleration either in a straight or a curved plasma channel. With the laser pulse off-axially injected, its centroid oscillates transversely in the plasma channel. This results in a wiggler motion of the whole accelerating structure and the self-trapped electrons behind the laser pulse, leading to strong synchrotron-like radiations with tunable spectra. It is further shown that a palmtop ring-shaped synchrotron is possible with current high power laser technologies. With its potential of high flexibility and tunability, such light sources once realized would find applications in wide areas and make up the shortage of large synchrotron radiation facilities

Electrostatic effect due to patch potentials between closely spaced surfaces

The spatial variation and temporal variation in surface potential are important error sources in various precision experiments and deserved to be considered carefully. In the former case, the theoretical analysis shows that this effect depends on the surface potentials through their spatial autocorrelation functions. By making some modification to the quasi-local correlation model, we obtain a rigorous formula for the patch force, where the magnitude is proportional to ${\frac{1}{{{a}^{2}}}{{(\frac{a}{w})}^{\beta (a/w)+2}}}$ with ${a}$ the distance between two parallel plates, ${w}$ the mean patch size, and ${\beta}$ the scaling coefficient from ${-2}$ to ${-4}$. A torsion balance experiment is then conducted, and obtain a 0.4 mm effective patch size and 20 mV potential variance. In the latter case, we apply an adatom diffusion model to describe this mechanism and predicts a ${f^{-3/4}}$ frequency dependence above 0.01 ${\rm mHz}$. This prediction meets well with a typical experimental results. Finally, we apply these models to analyze the patch effect for two typical experiments. Our analysis will help to investigate the properties of surface potentials

Genetic variants in ELOVL2 and HSD17B12 predict melanoma‐specific survival

Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single‐nucleotide polymorphisms (SNPs) in 149 genes of the fatty‐acid synthesis pathway with cutaneous melanoma disease‐specific survival (CMSS). The dataset of 858 cutaneous melanoma (CM) patients from a published genome‐wide association study (GWAS) by The University of Texas M.D. Anderson Cancer Center was used as the discovery dataset, and the identified significant SNPs were validated by a dataset of 409 CM patients from another GWAS from the Nurses’ Health and Health Professionals Follow‐up Studies. We found 40 noteworthy SNPs to be associated with CMSS in both discovery and validation datasets after multiple comparison correction by the false positive report probability method, because more than 85% of the SNPs were imputed. By performing functional prediction, linkage disequilibrium analysis, and stepwise Cox regression selection, we identified two independent SNPs of ELOVL2 rs3734398 T>C and HSD17B12 rs11037684 A>G that predicted CMSS, with an allelic hazards ratio of 0.66 (95% confidence interval = 0.51–0.84 and p = 8.34 × 10−4) and 2.29 (1.55–3.39 and p = 3.61 × 10−5), respectively. Finally, the ELOVL2 rs3734398 variant CC genotype was found to be associated with a significantly increased mRNA expression level. These SNPs may be potential markers for CM prognosis, if validated by additional larger and mechanistic studies