SIFTER search: a web server for accurate phylogeny-based protein function prediction.

We are awash in proteins discovered through high-throughput sequencing projects. As only a minuscule fraction of these have been experimentally characterized, computational methods are widely used for automated annotation. Here, we introduce a user-friendly web interface for accurate protein function prediction using the SIFTER algorithm. SIFTER is a state-of-the-art sequence-based gene molecular function prediction algorithm that uses a statistical model of function evolution to incorporate annotations throughout the phylogenetic tree. Due to the resources needed by the SIFTER algorithm, running SIFTER locally is not trivial for most users, especially for large-scale problems. The SIFTER web server thus provides access to precomputed predictions on 16 863 537 proteins from 232 403 species. Users can explore SIFTER predictions with queries for proteins, species, functions, and homologs of sequences not in the precomputed prediction set. The SIFTER web server is accessible at http://sifter.berkeley.edu/ and the source code can be downloaded

Linear and Non Linear Effects on the Newtonian Gravitational Constant as deduced from the Torsion Balance

The Newtonian gravitational constant has still 150 parts per million of uncertainty. This paper examines the linear and nonlinear equations governing the rotational dynamics of the torsion gravitational balance. A nonlinear effect modifying the oscillation period of the torsion gravitational balance is carefully explored.Comment: 11 pages, 2 figure

Performance of nano-structured multilayer PVD coating TiAlN/VN in dry high speed milling of aerospace aluminium 7010-T7651

A low-friction and wear resistant TiAlN/VN multilayer coating with TiAlN/VN bilayer thickness 3 nm has been grown by using the combined cathodic arc etching and unbalanced magnetron sputtering deposition on high speed steel tools for dry cutting of aluminium alloys. In this paper, in-lab and industrial high speed milling tests have been performed on an aerospace aluminium alloy 7010-T7651. The results show that the TiAlN/VN coated tools achieved lower cutting forces, lower metal surface roughness, and significantly longer tool lifetime by three times over the uncoated tools as a result of the low friction and eliminated tool-metal adhesion. Under the same conditions, a TiAlN based multicomponent coating TiAlCrYN also increased the tool lifetime by up to 100% despite the high cutting forces measured

Unparticle effects in rare (t -> c g g) decay

Rare (t -> c g g) decay can only appear at loop level in the Standard Model (SM), and naturally they are strongly suppressed. These flavor changing decays induced by the mediation of spin-0 and spin-2 unparticles, can appear at tree level in unparticle physics. In this work the virtual effects of unparticle physics in the flavor-changing (t -> c g g) decay is studied. Using the SM result for the branching ratio of the (t -> c g g) decay, the parameter space of d_U and Lambda_U, where the branching ratio of this decay exceeds the one predicted by the SM, is obtained. Measurement of the branching ratio larger than 10^(-9) can give valuable information for establishing unparticle physics.Comment: 15 pages, 7 figures, LaTeX formatte

Spherical geometry and integrable systems

We prove that the cosine law for spherical triangles and spherical tetrahedra defines integrable systems, both in the sense of multidimensional consistency and in the sense of dynamical systems.Comment: 15 pages, 5 figure

Geographic and Seasonal Distributions of CO Transport Pathways and Their Roles in Determining CO Centers in the Upper Troposphere

Past studies have identified a variety of pathways by which carbon monoxide (CO) may be transported from the surface to the tropical upper troposphere (UT); however, the relative roles that these transport pathways play in determining the distribution and seasonality of CO in the tropical UT remain unclear. We have developed a method to automate the identification of two pathways ('local convection' and 'advection within the lower troposphere (LT) followed by convective vertical transport') involved in CO transport from the surface to the UT. This method is based on the joint application of instantaneous along-track, co-located, A-Train satellite measurements. Using this method, we find that the locations and seasonality of the UT CO maxima in the tropics were strongly correlated with the frequency of local convective transport during 2007. We also find that the 'local convection' pathway (convective transport that occurred within a fire region) typically transported significantly more CO to the UT than the 'LT advection -> convection' pathway (advection of CO within the LT from a fire region to a convective region prior to convective transport). To leading order, the seasonality of CO concentrations in the tropical UT reflected the seasonality of the 'local convection' transport pathway during 2007. The UT CO maxima occurred over Central Africa during boreal spring and over South America during austral spring. Occurrence of the 'local convection' transport pathway in these two regions also peaked during these seasons. During boreal winter and summer, surface CO emission and convection were located in opposite hemispheres, which limited the effectiveness of transport to the UT. During these seasons, CO transport from the surface to the UT typically occurred via the 'LT advection -> convection' pathway.NASA Aura Science Team NNX09AD85GJackson School of Geosciences at the University of Texas at AustinNASA Jet Propulsion Laboratory at the California Institute of TechnologyGeological Science