Interview of John Lukacs, Ph.D.

John Lukacs was born in 1924 in Budapest Hungary. He grew up in a middle class family raised by a Roman Catholic Father, and a Jewish mother. While he received most of his education in Hungary, he went to high school in Great Britain during his teenage years. During the Second World War, he was drafted into a forced labor battalion for much of the war. When German troops occupied Hungary in late 1944, he had to avoid getting sent to death camps by avoiding German patrols. In addition, he had to avoid being caught in the crossfire during the Siege of Budapest in December 1944 when the Soviets slowly pushed the Germans out of the city. After a living under Soviet occupied Budapest for less than a year, he left for the United States in 1946. In the United States, he worked at Chestnut Hill and LaSalle teaching history. Although he taught at both institutions until the 1980s, he preferred writing books and other academic articles not limited to: Winston Churchill, Hitler, the Soviet Union, the Eastern Bloc, and Pennsylvania history. Even after retirement, he wrote prolifically, publishing many works. He has been married three times and has two children. As of the time of the interview, he had no plans of writing in the foreseeable future. He currently resides in Phoenixville, PA. This interview focuses on his years and work as an educator full-time at Chestnut Hill College and part-time at La Salle College

Dates, Caries, and Early Tooth Loss During the Iron Age of Oman

Eine Ernährung aus fermentierbaren Kohlenhydraten ist bekannterweise hoch kariogen, besonders im Falle von zuckerhaltigem Essen wie zum Beispiel Datteln. Diese Ernährung ist bei der späteisenzeitlichen Samad-zeitlichen Bevölkerung Omans zu beobachten. 32 Erwachsene und 5 Jugendliche dienten für diese Studie als Erhebung. Vorzeitiger Zahnverlust war in allen Fällen nachweisbar

Hit-to-kill guidance algorithm for the interception of ballistic missiles during the boost phase

A near-optimal guidance law has been developed using the direct method of calculus of variations that maximizes the kinetic energy transfer from a surface-launched missile upon interception to a ballistic missile target during the boost phase of flight. Mathematical models of a North Korean Taep'o-dong II (TD-2) medium-range ballistic missile and a Raytheon Standard Missile 6 (SM-6) interceptor are used to demonstrate the guidance lawâ s performance. This law will utilize the SM-6â s onboard computer and active radar sensors to independently predict an intercept point, solve the two-point boundary value problem, and determine a near-optimal flight path to that point. Determining a truly optimal flight path would require significant computing power and time, while a near-optimal flight path can be calculated onboard the interceptor and updated in real time without significant changes to the interceptorâ s hardware. That near-optimal guidance path is then converted into a set of command functions and fed back into the control computer of the interceptor. By modifying the second and third derivatives of the two-point boundary value problem, the intercept conditions can be varied to study their effects upon the optimal flight path regarding the maximization of kinetic energy upon impact.http://archive.org/details/hittokillguidanc109452829US Navy (USN) author

Effects of Eutrophication and Runoff on Arsenic Cycling in an Urban Lake

Urban lakes are important recreational and natural resources that add to the quality of life for city residents. Unfortunately, urban watersheds often contribute contaminants to these lakes, including organic chemicals, metals, nutrients, and pathogens. Nitrogen and phosphorus are very high in urban and suburban runoff, mostly as a result of animal waste and fertilizers, although leaky sewage systems may also contribute. These nutrients promote plant and algal growth in urban lakes, ultimately resulting in hyper-eutrophic conditions. Eutrophication, in turn, may affect the cycling and mobility of contaminants, such as arsenic and other toxic metals. Spy Pond, located in Arlington, Massachusetts, was recently discovered to be heavily contaminated with arsenic of unknown origin. Surface sediment concentrations above 2,500 ppm have been measured. Subsequent investigations have also revealed that total arsenic levels in the overlying hypolimnetic waters reach over 150 ppb. However, the two interconnected basins that constitute Spy Pond have been found to differ by an order of magnitude in the concentrations of arsenic found in hypolimnetic waters. The goal of this study is to determine the mechanisms responsible for the differences in arsenic mobility in the two basins of Spy Pond, and how this may impact the potential for minimizing human and ecological arsenic exposure. Based on differences in the concentrations of chemical constituents (e.g. iron, sulfur, conductivity, etc.) measured in each basin, we hypothesize that the greater arsenic concentrations found in the bottom waters of the South Basin of Spy Pond are caused by the combined effects of eutrophication, differences in the Fe/S ratio of the two basins, and the physical and chemical impacts of salts in highway runoff

Bioactive Thymosin Alpha-1 Does Not Influence F508del-CFTR Maturation and Activity.

Deletion of phenylalanine 508 (F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel is the most frequent mutation causing cystic fibrosis (CF). F508del-CFTR is misfolded and prematurely degraded. Recently thymosin a-1 (Tα-1) was proposed as a single molecule-based therapy for CF, improving both F508del-CFTR maturation and function by restoring defective autophagy. However, three independent laboratories failed to reproduce these results. Lack of reproducibility has been ascribed by the authors of the original paper to the use of DMSO and to improper handling. Here, we address these potential issues by demonstrating that Tα-1 changes induced by DMSO are fully reversible and that Tα-1 peptides prepared from different stock solutions have equivalent biological activity. Considering the negative results here reported, six independent laboratories failed to demonstrate F508del-CFTR correction by Tα-1. This study also calls into question the autophagy modulator cysteamine, since no rescue of mutant CFTR function was detected following treatment with cysteamine, while deleterious effects were observed when bronchial epithelia were exposed to cysteamine plus the antioxidant food supplement EGCG. Although these studies do not exclude the possibility of beneficial immunomodulatory effects of thymosin α-1, they do not support its utility as a corrector of F508del-CFTR

Discovery of a potent nanoparticle P‐selectin antagonist with anti‐inflammatory effects in allergic airway disease

The severity of allergic asthma is dependent, in part, on the intensity of peribronchial inflammation. P‐selectin is known to play a role in the development of allergen‐induced peribronchial inflammation and airway hyperreactivity. Selective inhibitors of P‐selectin‐ mediated leukocyte endothelial‐cell interactions may therefore attenuate the inflammatory processes associated with allergic airway disease. Novel P‐selectin inhibitors were created using a polyvalent polymer nanoparticle capable of displaying multiple synthetic, low molecular weight ligands. By assembling a particle that presents an array of groups, which as monomers interact with only low affinity, we created a construct that binds extremely efficiently to P‐ selectin. The ligands acted as mimetics of the key binding elements responsible for the high‐ avidity adhesion of P‐selectin to the physiologic ligand, PSGL‐1. The inhibitors were initially evaluated using an in vitro shear assay system in which interactions between circulating cells and P‐selectin‐coated capillary tubes were measured. The nanoparticles were shown to preferentially bind to selectins expressed on activated endothelial cells. We subsequently demonstrated that nanoparticles displaying P‐selectin blocking arrays were functionally active in vivo, significantly reducing allergen‐induced airway hyperreactivity and peribronchial eosinophilic inflammation in a murine model of asthma.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154265/1/fsb2fj030166fje-sup-0001.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154265/2/fsb2fj030166fje.pd

H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM‐1 and TLR3 expression

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154674/1/fsb2fj065806fje.pd

Lipoxin A4 stable analogs reduce allergic airway responses via mechanisms distinct from CysLT1 receptor antagonism

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154665/1/fsb2fj078653com.pd