Assessment and antimricrobial modulating activity of the extract of Baccharis cinerea DC. from cariri cearense

Baccharis cinerea belongs to the Asteraceae family, in Brazil is found in the Northeast and Southeast, occurring in the Caatinga and Mata Atlântica biomes, on the edges of the seasonal forests, board and altitude forests in both regenerating primary and secondary areas. Has proven antimicrobial and antiviral activity and is widely used in folk medicine for its various therapeutic effects and is used as an antiseptic for skin and wound infections, inflammation, diarrhea as well as being used as a purgative. The plants used in the traditional medicine are more and more explored scientifically because they are possible resources of substances with antimicrobial activity in front damage man’s health microorganism. In this context the objective of the study was to investigate the antimicrobial activity, modulator activity of antibiotic and in vitro phytochemical prospection of leaf ethanol extracts. Tests were performed on the bacterial strains of Staphylococcus aureus (ATCC 25923), Pseudomonas aeruginosa (ATCC 15442) and Escherichia coli (ATCC 10536). The antibacterial activity was analyzed by means determining the Minimum Inhibitory Concentration (MIC). For the evaluation of the modulating activity, the microdilution method of the diluted extract samples with the antibiotic’s amikacin, clindamycin and gentamicin was used. The MIC results were ≥ 1024 μg mL-1 by the bacterial strains. There was a relevance of concentrations in modulation with the antimicrobials tested such as amikacin and gentamicin, there were no discrepancy of clindamycin results in association with the extract. The chemical constituents found were leucoanthocyanidins, flabobenic tannins, flavanones, flavones, flavonoids, xanthones, chalcones, aurones. It is important to note that is necessary to do other studies to evaluate the potential of this species because it has important chemical compounds in reducing antimicrobial resistance

Efeito antimicrobiano e modulador do extrato hidroalcoólico de Genipa americana (Jenipapo)

Genipa americana, belonging to the family Rubiaceae, a large tree that is found in several areas of Brazil, popularly known as Jenipapeiro being used to combat liver and inflammatory diseases, and reduce cholesterol This study has as main objective to evaluate the phytochemical, antibacterial and modulatory prospection of the hydroalcoholic extract of the stem bark of Genipa americana against strains of standard and multiresistant bacteria. For the analysis of the antibacterial activity of the hydroalcoholic extract, the broth microdilution test was carried out to determine the minimum inhibitory concentration (MIC), and the antimicrobial modulation by means of gentamicin, amikacin and clindamycin. The results obtained from the MIC by the bacteria Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were ≥ 1024 μg / mL. In the modulation modulation of the concentration of two antibiotics for each bacterial strain. Thus, it is a fact to conclude that this extract has remarkable modulatory activity, especially when tested against bacteria of clinical interest, such as P. aeruginosa, opportunistic bacteria, stressing that more research should be done on the potential of this species, which has important phytochemical compounds capable to reduce antimicrobial resistance.Genipa americana, pertencente à família Rubiaceae, árvore de grande porte que é encontrada em várias áreas do Brasil, popularmente conhecida como Jenipapeiro sendo utilizada para no combate à doenças hepáticas e inflamatórias, além de reduzir o colesterol. Este estudo tem como principal objetivo avaliar a prospecção fitoquímica, antibacteriana e modulatória do extrato hidroalcoólico da casca do caule de Genipa americana frente a cepas de bactérias padrões e multirresistentes. Para a análise da atividade antibacteriana do extrato hidroalcoólico, foi realizado o teste de microdiluição em caldo para determinação da concentração inibitória mínima (CIM), e a modulação de antimicrobianos por meio de gentamicina, amicacina e clindamicina. Os resultados obtidos da CIM pelas bactérias Escherichia coli, Staphylococcus aureus e Pseudomonas aeruginosa foram ≥ 1024µg/mL. Na modulação modificação da concentração de dois antibióticos para cada cepa bacteriana. Assim, é fato rematar que este extrato tem notável atividade moduladora principalmente quando testados contra bactérias de interesse clínico como a P. aeruginosa, bactérias oportunista, ressaltando que deve-se ser realizados mais estudo sobre o potencial desta espécie, que possui compostos fitoquímicos importantes capazes de reduzir a resistência a antimicrobianos