Space VLBI Observations of 3C371

We present the first space VLBI observations of 3C~371, carried out at a frequency of 4.8 GHz. The combination of the high resolution provided by the orbiting antenna Highly Advanced Laboratory for Communications and Astronomy (HALCA) and the high sensitivity of the VLBA allows imaging of the jet of 3C~371 with an angular resolution of approximately 0.26 mas, which for this relatively nearby source corresponds to $\sim$ 0.4 h$^{-1}$ pc. Comparison between two epochs separated by 66 days reveals no apparent motions in the inner 7 mas jet structure above an upper limit of $\sim 1.4 h^{-1}$ c. This value, the absence of detectable counterjet emission from the presumably symmetric jet, plus the presence of extended double-lobe structure, are consistent with the knots in the jet being stationary features such as standing shocks. The jet intensity declines with the angular distance from the core as $\phi^{-1.68}$. This is more gradual than that derived for 3C~120, $\phi^{-1.86}$, for which there is evidence for strong intereactions between the jet and ambient medium. This suggests that in 3C~371 there is a greater level of {\it in situ} acceleration of electrons and amplification of magnetic field. We interpret sharp bends in the jet at sites of off-center knots as further evidence for the interaction between the jet and external medium, which may also be responsible for the generation of standing recollimation shocks. These recollimation shocks may be responsible for the presumably stationary components. The radio properties of 3C~371 are intermediate between those of other radio galaxies with bright cores and those of BL Lacertae objects.Comment: 5 pages, 4 figures. Accepted for publication in Ap

Finite temperature effective action, AdS_5 black holes, and 1/N expansion

We propose a phenomenological matrix model to study string theory in AdS_5 \times S_5 in the canonical ensemble. The model reproduces all the known qualitative features of the theory. In particular, it gives a simple effective potential description of Euclidean black hole nucleation and the tunnelling between thermal AdS and the big black hole. It also has some interesting predictions. We find that there exists a critical temperature at which the Euclidean small black hole undergoes a Gross-Witten phase transition. We identify the phase transition with the Horowitz-Polchinski point where the black hole horizon size becomes comparable to the string scale. The appearance of the Hagedorn divergence of thermal AdS is due to the merger of saddle points corresponding to the Euclidean small black hole and thermal AdS. The merger can be described in terms of a cusp (A_3) catastrophe and divergences at the perturbative string level are smoothed out at finite string coupling using standard techniques of catastrophe theory.Comment: 41 pages, 3 eps figures, uses harvma

A survey for water maser emission towards planetary nebulae. New detection in IRAS 17347-3139

We report on a water maser survey towards a sample of 27 planetary nebulae (PNe) using the Robledo de Chavela and Medicina single-dish antennas, as well as the Very Large Array (VLA). Two detections have been obtained: the already known water maser emission in K 3-35, and a new cluster of masers in IRAS 17347-3139. This low rate of detections is compatible with the short life-time of water molecules in PNe (~100 yr). The water maser cluster at IRAS 17347-3139 are distributed on a ellipse of size ~ 0.2" x 0.1", spatially associated with compact 1.3 cm continuum emission (simultaneously observed with the VLA). From archive VLA continuum data at 4.9, 8.4, and 14.9 GHz, a spectral index alpha = 0.76 +- 0.03 is derived for this radio source, which is consistent with either a partially optically thick ionized region or with an ionized wind. However, the latter scenario can be ruled out on mass-loss considerations, thus indicating that this source is probably a young PN. The spatial distribution and the radial velocities of the water masers are suggestive of a rotating and expanding maser ring, tracing the innermost regions of a torus formed at the end of the AGB phase. Given that the 1.3 cm continuum emission peak is located near one of the tips of the major axis of the ellipse of masers, we speculate on a possible binary nature of IRAS 17347-3139, where the radio continuum emission could belong to one of the components and the water masers would be associated with a companion.Comment: Accepted by The Astrophysical Journal. 25 pages, 6 figure

NGcGM3 Ganglioside: A Privileged Target for Cancer Vaccines

Active specific immunotherapy is a promising field in cancer research. N-glycolyl (NGc) gangliosides, and particularly NGcGM3, have received attention as a privileged target for cancer therapy. Many clinical trials have been performed with the anti-NGc-containing gangliosides anti-idiotype monoclonal antibody racotumomab (formerly known as 1E10) and the conjugated NGcGM3/VSSP vaccine for immunotherapy of melanoma, breast, and lung cancer. The present paper examines the role of NGc-gangliosides in tumor biology as well as the available preclinical and clinical data on these vaccine products. A brief discussion on the relevance of prioritization of cancer antigens in vaccine development is also included

Population and production parameters of the wedge clam Donax trunculus (Linnaeus, 1758) in intertidal areas on the southwest Spanish coast: Considerations in relation to protected areas

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Mechanisms of Carbapenemase-Mediated Resistance among High-Risk \u3cem\u3ePseudomonas aeruginosa \u3c/em\u3e Lineages in Peru

Objectives: Pseudomonas aeruginosa is one of the leading causes of healthcare-associated infections globally. High-risk carbapenemase-encoding P. aeruginosa clones are disseminating in many regions. The aim of this study was to learn more about the lineages and mechanisms of resistance of P. aeruginosa circulating in Peru. Methods: A total of 141 carbapenemase-producing isolates recovered from hospitalized and ambulatory patients in Lima were sequenced and analyzed to infer their lineages through whole-genome sequence typing (wgST) and to identify their antimicrobial resistance genes. Results: wgST identified nine sequence types (STs); ST111 and ST357 were the most frequently encountered (44.0% and 38.3%, respectively), followed by ST179 (8.5%), with the remaining six detected only sporadically. Among ST357 isolates, 96.3% carried the novel blaIMP-93 allele, whereas the remainder harbored blaIMP-74. 74.2% of ST111 isolates co-harbored blaIMP-18 and blaVIM-2, while the rest carried either of these genes individually. All other ST lineages carried a single carbapenemase, which was either blaIMP-16, blaIMP-74, or blaVIM-2. Conclusion: Our study shows that the high-risk P. aeruginosa clones ST357, which harbors the novel blaIMP-93, and ST111, which carries blaIMP-18 and blaVIM-2, have apparently become endemic in the region