"Development Plan for the Project: Integrated System for Patient Localization, Tracking and Monitoring in an Indoor Environment"

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AN INTEGRATED SYSTEM FOR INDOOR PEOPLE LOCALIZATION, TRACKING, AND MONITORING

Human activity monitoring technologies are one of the essential systems for elderly care. Advances in electronic systems, sensor technologies, and communication network protocols have enabled a new generation of integrated health systems to be created. The solution presented in this document represents an integrated system prototype that provides an efficient technological tool to caregivers operating promptly and ensures efficient performance throughout the entire healthcare system process. This solution differs from previous works for the coexistence of a series of innovative aspects. Human activity recognition is based on combining different types of information: environmental data, physiological data, inertial data, and indoor location data of patients; CNN network for locating position and activities; Virtual Reality System (VR) for optimizing the neural network and related training

An Overview of Indoor Localization System for Human Activity Recognition (HAR) in Healthcare

The number of older people needing healthcare is a growing global phenomenon. The assistance in long-term care comprises a complex of medical, nursing, rehabilitation, and social assistance services. The cost is substantial, but technology can help reduce spending by ensuring efficient health services and improving the quality of life. Advances in artificial intelligence, wireless communication systems, and nanotechnology allow the creation of intelligent home care systems avoiding hospitalization with evident cost containment. They are capable of ensuring functions of recognition of activities, monitoring of vital functions, and tracking. However, it is essential to also have information on location in order to be able to promptly intervene in case of unforeseen events or assist people in carrying out activities in order to avoid incorrect behavior. In addition, the automatic detection of physical activities performed by human subjects is identified as human activity recognition (HAR). This work presents an overview of the positioning system as part of an integrated HAR system. Lastly, this study contains each technology’s concepts, features, accuracy, advantages, and limitations. With this work, we want to highlight the relationship between HAR and the indoor positioning system (IPS), which is poorly documented in the literature

Twisted Bands with Degenerate Points of Photonic Hypercrystals in Infrared Region

Photonic hypercrystals (PHCs) are materials combining hyperbolic metamaterials (HMMs) with widely used photonic crystals. We found that finite-sized Type-I HMMs can support unique electromagnetic modes, which could be utilized in two-dimensional photonic crystals to achieve PHCs with twisted bands in the infrared region. Numerical investigation of the PHCs showed that the twisted bands have degenerate points that can support all-angle self-collimation effects. The behaviors of light beams change dramatically in such bands, which provides an effective method in controlling light propagation and can be applied as switching. The effect of the filling factor and the permittivity of the dielectric medium of the HMM on the twisted bands were studied. Furthermore, by considering the nonlinear effect of the dielectric layers, an all-optical switch working on the PHC twisted bands is proposed, which has low switching power and high extinction ratio (19.75 dB), superior to conventional HMM switches that require type transformation of metamaterial

Men’s Suicide by Self-abdominal Cut and Disembowelment: A Literature Review and Analysis of Three Cases

Introduction: Suicide by abdominal cut wounds and consequent disembowelment is a modality rarely described in the literature, with rates between 1.6% and 3%. The incidence is higher in men. This type of suicide might be so unusual as the abdominal injuries are not supposed to be related to immediate death (compared to the wrists or throat, which involves rapid bleeding, for example). Considering the infrequency of suicides by abdominal self-cutting, in such cases, the main hypothesis is a homicide, especially in those with multiple injuries or occurred in a complex setting. These cases require a detailed autopsy report with the analysis of the injuries and circumstances of death (e.g., farewell note, history of depression, previous suicide attempts, defense injuries, and signs of hesitation) to allow a differential diagnosis between suicide and homicide. This study aims to highlight the characteristics of suicides through self-cut wounding, focusing on those that determine a large abdominal opening and evisceration. Methods: The authors conducted the literature search using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, on PubMed and Scopus databases, using the following keywords: “(suicide) AND (abdominal stab wounds)”, “(suicide) AND (abdominal sharp injuries)”, “(suicide) AND (abdominal self-stabbing)”, “(suicide) AND (abdominal cut wounds)”. Results: 7 articles were included in the systematic review, for a total of 11 cases of suicide by abdominal self-cutting. Of these cases, 3 were women and 8 were men. Conclusions: The analysis of the external examination findings versus the crime scene results is essential to clarify if injuries are self-inflicted with suicidal intention. Suicide through a violent act can also be practiced by people who have no history of psychiatric conditions or other risk factors. Therefore, in cases of abdominal cut and evisceration with victims’ survival time, the forensic pathologist has to consider that the deceased himself could cause modifications to the crime scene, turning it into a complicated suicide

DDDR-32. A NEW IMMUNOMODULATORY FUNCTION OF PYRIDO-PYRIMIDINE DERIVATIVES TO IMPAIR METASTATIC GROUP 3 MEDULLOBLASTOMA IN VIVO

Medulloblastoma (MB) is an embryonal tumor of the cerebellum consti- tuting ~ 20% of pediatric brain tumors. To date, four MB molecular groups (further stratified in twelve subtypes) have been described. Among them, Groups 3 and Group 4 MB have the poorest prognosis due to their high metastatic potential. Recently, we have reported a metastatic axis driven by Prune1 overexpression in MB Group3 characterized by canonical TGF-β signaling enhancement and epithelial-mesenchymal transition. Here, we have developed a new not toxic pyrido-pyrimidine derivative with the ability to impair Prune-1-driven-axis, thus ameliorating the survival rate of a murine model of metastatic MB Group3 characterized by overexpression of human Prune1 gene in the cerebellum (under the control of MATH1 promoter). Of importance, this small molecule also is showing immunomodulatory functions thus inhibiting the conversion of tumor-infiltrating T lymphocytes (TILs) to immunosuppressive regulatory T cells (Tregs) in vivo via impairing the secretion of inflammatory cytokines from MB cells. Furthermore, this molecule can also act synergistically with the currently used modified- intensity chemotherapy (e.g. in PNET5 use of Vincristine) or potential in the combination with epigenetics drugs (e.g., LSD1/KDM1A inhibitors). Altogether these results are of importance for future targeted therapies of high-risk metastatic MB