Diatomáceas Epifíticas (diatomeae) No Reservatório Urbano Piraquara Ii, Estado Do Paraná

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)We conducted a taxonomical study of epiphytic diatoms on the macrophytes Polygonum hydropiperoides, Ludwigia peruviana and Alternanthera philoxeroides collected in the mesotrophic reservoir Piraquara II flooded in 2009, located in the state of Paraná. A total of 135 infrageneric taxa were identified, among them five at generic level and other five are first records to the state. We provided illustration, valve metrics, meristics limits and taxonomic reference for each taxon. Also, life forms and species frequency are given. The most frequent diatoms totalized 15.3% of total identified taxa and sporadic species represented 54.7%. Achnanthidium minutissimum (Kützing) Czarnecki and Brachysira neoexilis Lange-Bertalot occurred in more than 90% of analyzed samples. Among the very frequent diatoms we found other species included in Achnantidium, Fragilaria and Eunotia. The solitary Discotella stelligera (Cleve & Grunow) Houk & Klee and the short chain Aulacoseira tenella (Nygaard) Simonsen are free living species that entangle among diatoms from the biofilm. © 2016, Universidade Estadual de Campinas UNICAMP. All rights reserved.164CNPq, Conselho Nacional de Desenvolvimento Científico e TecnológicoConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq

The oldest (~ 1.9 Ga) metadolerites of the southern Siberian craton: age, petrogenesis, and tectonic setting

Geological, geochronological, and isotope-geochemical studies of the metadolerites of the Angaul complex, widespread in the Urik-Iya graben of the southern Siberian craton, were carried out. The metadolerites forming separate conformal bodies (sills) among the metasandstones of the Ingash Formation were studied in detail. U-Pb zircon (SHRIMP) dating of metadolerites yielded an age of 1913 ± 24 Ma, and U-Pb baddeleyite (ID-TIMS) dating of these rocks yielded an age of 1914.0 ± 1.7 Ma. Thus, the date of 1914 ± 2 Ma can be taken as the most precise age estimate for the studied rocks. The metadolerites of the Angaul complex correspond in chemical composition to the normal-alkaline tholeiitic basalts. Metadolerites are differentiated rocks with mg# of 36 to 58. They show fractionated REE patterns: (La/Yb)n = 1.2-3.5. All metadolerites, independently of their mg# value, have low contents of Nb (1.6-10.2 ppm) and show well-pronounced negative Nb-Ta anomalies in multielement patterns (Nb/Nb* = 0.19-0.54). The metadolerites are characterized by positive eNd(T) values ranging from 0.4 to 5.2, which correlate well with their SiO2 content and mg# value. The isotope-geochemical parameters of the metadolerites of the Angaul complex indicate that fractional crystallization, along with the assimilation of the host rocks (AFC), might have been the main process during the formation of the most differentiated metadolerites. The geochemical characteristics of metadolerites with the maximum mg# values of 57-58 and eNd(T) = 5.2 suggest that the parental mantle source of the metadolerites resulted from mixing of predominant depleted mantle material with the subcontinental-lithosphere material. Intrusion of the dolerites of the Angaul complex, as well as the deposition of the sedimentary strata of the Ingash Group, took place at the Paleoproterozoic stage of intracontinental extension caused by the collapse of the orogen resulted from the collision of the Biryusa block with the Tunguska superterrane in the southern Siberian craton

Radiotherapy Combined with the Immunocytokine L19-IL2 Provides Long-lasting Antitumor Effects

Purpose: Radiotherapy modifies the tumor microenvironment and causes the release of tumor antigens, which can enhance the effect of immunotherapy. L19 targets the extra domain B (ED-B) of fibronectin, a marker for tumor neoangiogenesis, and can be used as immunocytokine when coupled to IL2. We hypothesize that radiotherapy in combination with L19-IL2 provides an enhanced antitumor effect, which is dependent on ED-B expression. Experimental Design: Mice were injected with syngeneic C51 colon carcinoma, Lewis lung carcinoma (LLC), or 4T1 mammary carcinoma cells. Tumor growth delay, underlying immunologic parameters, and treatment toxicity were evaluated after single-dose local tumor irradiation and systemic administration of L19IL2 or equimolar controls. Results: ED-B expression was high, intermediate, and low for C51, LLC, and 4T1, respectively. The combination therapy showed (i) a long-lasting synergistic effect for the C51 model with 75% of tumors being cured, (ii) an additive effect for the LLC model, and (iii) no effect for the 4T1 model. The combination treatment resulted in a significantly increased cytotoxic (CD8(+)) T-cell population for both C51 and LLC. Depletion of CD8(+) T cells abolished the benefit of the combination therapy. Conclusions: These data provide the first evidence for an increased therapeutic potential by combining radiotherapy with L19-IL2 in ED-B-positive tumors. This new opportunity in cancer treatment will be investigated in a phase I clinical study for patients with an oligometastatic solid tumor (NCT02086721). An animation summarizing our results is available at https://www.youtube.com/watch?v=xHbwQuCTkRc