Henri Temianka Correspondence; (luckman)

https://digitalcommons.chapman.edu/temianka_correspondence/2333/thumbnail.jp

10/21/1947 Western Union Telegram

A Western Union telegram from Charles Luckman, Chair of the President\u27s Citizens Food Committee to Louis-Philippe Gagné concerning the European food crisis.https://digitalcommons.usm.maine.edu/fac-lpg-1947-10-12/1015/thumbnail.jp

11/03/1947 Letter from the Citizens Food Committee

Letter from Charles Luckman of the Citizens Food Committee to Louis-Philippe Gagné concerning the European food crisis.https://digitalcommons.usm.maine.edu/fac-lpg-1947-10-12/1025/thumbnail.jp

General Atomic Laboratories. San Diego - California

El edificio está emplazado en un espacioso solar de Torrey Pines Mesa, situado en la parte norte de la ciudad de San Diego (California). Los servicios fundamentales comprenden un bloque administrativo; una gran construcción experimental; dos edificios de forma semicilíndrica, en los que se encuentran los laboratorios particulares y las oficinas correspondientes; y otro edificio, de planta circular, en el que está la biblioteca y que, además, sirve para centro de reuniones, conferencias e información técnica. También existe un edificio en el que se encuentra el acelerador lineal de partículas, otros dos que sirven para la investigación de la fisión nuclear y el salón de reuniones. El complejo de los laboratorios, incluyendo los edificios auxiliares y de servicio, ocupa aproximadamente 24.000 m2 y es uno de los mayores y mejor acondicionados para la investigación nuclear privada del mundo

11/29/1947 Western Union Telegram

A Western Union telegram from Charles Luckman, Chairman of the Citizens Food Committee, to Louis-Philippe Gagné regarding a rescheduled meeting and continued food conservation.https://digitalcommons.usm.maine.edu/fac-lpg-1947-10-12/1038/thumbnail.jp

Nueva York. Centro deportivo y recreativo

Charles Luckman Asociados, oficina de proyectos de Los Angeles y Nueva York, ha recibido el encargo de proyectar un centro deportivo y recreativo, con presupuesto de 38 millones de dólares, por parte del Almirante John J. Bergen y de Irving Mitchell Felt, presidente y director, respectivamente, de la Graham-Paige Corporation, propietaria del Madison Square Garden

11/08/1947 Western Union Telegram

A Western Union telegram from Charles Luckman, Chairman of the Citizens Food Committee, to Louis-Philippe Gagné concerning local food committee activities.https://digitalcommons.usm.maine.edu/fac-lpg-1947-10-12/1028/thumbnail.jp

Sede central Ralph M. Parsons Company Pasadena (EE. UU.)

The new main complex for the Parsons Company is built on a 65,000 m2 lot, in a central área of the City of Pasadena affected by an urban renewai program. The built surface of 42,700 m2 consists of a 12-story central tower, with 1,400 m2 per floor and three satellite buildings, around the tower, with three stories each and a surface of 2,300 m2 per floor; at ground level additional space of 4,200 m2 per floor has been foreseen. The complex has 1,400 outdoor parking spaces in addition to 70 indoor parking spaces, located in two of the satellite bodies. The architects main objective was to give the building a solid and sturdy image, representative of the Company's activity —one of the world's leading engineering firms—by enclosing the exterior volumes with prefabricated concrete panel s. The lay-out of each floor was studied in order to permit adaptation to varied and flexible schemes.El nuevo complejo de oficinas centrales para la Parsons Company está construido en una parcela de 65.000 m2 de superficie, en una zona céntrica de Pasadena afectada por un programa de remodelación urbana. Los 41.700 m2 edificados comprenden una torre central de 12 plantas, con 1.400 m2 por planta, y tres construcciones satélites, alrededor de la primera, con tres alturas cada una y una superficie en planta de 2.300 m2; a nivel del terreno se ha provisto un espacio adicional de 4.200 m2. El conjunto cuenta con 1.400 plazas de aparcamiento, distribuidas en la superficie exterior, a las que se añaden 70 plazas cubiertas emplazadas en dos de los cuerpos satélites. Fue propósito de los arquitectos proporcionar al edificio una imagen sólida y robusta, representativa de la actividad de la Compañía —una de las empresas de ingeniería más importantes del mundo—, mediante un cerramiento de los volúmenes exteriores a base de paneles prefabricados de hormigón. Interiormente, las plantas fueron estudiadas de modo que permitan la adopción de esquemas variados y reflexibles de distribución

Fluorescent Risedronate Analogues Reveal Bisphosphonate Uptake by Bone Marrow Monocytes and Localization Around Osteocytes In Vivo

Bisphosphonates are effective antiresorptive agents owing to their bone-targeting property and ability to inhibit osteoclasts. It remains unclear, however, whether any non-osteoclast cells are directly affected by these drugs in vivo. Two fluorescent risedronate analogues, carboxyfluorescein-labeled risedronate (FAM-RIS) and Alexa Fluor 647–labeled risedronate (AF647-RIS), were used to address this question. Twenty-four hours after injection into 3-month-old mice, fluorescent risedronate analogues were bound to bone surfaces. More detailed analysis revealed labeling of vascular channel walls within cortical bone. Furthermore, fluorescent risedronate analogues were present in osteocytic lacunae in close proximity to vascular channels and localized to the lacunae of newly embedded osteocytes close to the bone surface. Following injection into newborn rabbits, intracellular uptake of fluorescently labeled risedronate was detected in osteoclasts, and the active analogue FAM-RIS caused accumulation of unprenylated Rap1A in these cells. In addition, CD14high bone marrow monocytes showed relatively high levels of uptake of fluorescently labeled risedronate, which correlated with selective accumulation of unprenylated Rap1A in CD14+ cells, as well as osteoclasts, following treatment with risedronate in vivo. Similar results were obtained when either rabbit or human bone marrow cells were treated with fluorescent risedronate analogues in vitro. These findings suggest that the capacity of different cell types to endocytose bisphosphonate is a major determinant for the degree of cellular drug uptake in vitro as well as in vivo. In conclusion, this study shows that in addition to bone-resorbing osteoclasts, bisphosphonates may exert direct effects on bone marrow monocytes in vivo. © 2010 American Society for Bone and Mineral Researc