Renacer: analysis of a journal from the bolivian comunity in Argentina

El presente trabajo analiza la construcción de una producción comunicacional gráfica significativa dentro de lo que velozmente se denomina “comunidad boliviana en la Argentina” como es el periódico Renacer. Este periódico, que ha cumplido trece años desde su aparición y circulación ininterrumpida en la Ciudad de Buenos Aires constituye una herramienta que trasciende el esquema del periódico clásico para inscribirse dentro de una matriz de construcción identitaria de la inmigración proveniente de Bolivia en la Argentina. Esa matriz, lejos de expresar lo que la lógica hegemónica en Argentina ha instituido alrededor de la inmigración regional en general, y de la boliviana en particular (homogeneidad, pasividad, docilidad, extranjeridad, etc.), pone en evidencia la complejidad de la inmigración así como la de sus identificaciones Renacer, a su vez, invita a ciertos desafíos teóricos para las Ciencias de la Comunicación y la Antropología, en tanto evidencia la intervención política de una polifonía que ha sido negada, ocultada o reprimida a lo largo de la historia de la Argentina. Esa polifonía expresa complejidades y heterogeneidades “comunitarias” que desarman la homogeneidad y esencialidad atribuida a la identidad y obliga a abordarla desde su inherente diversidad, conflictividad y politicidad. Circunscribiendo el análisis a la primera década del siglo XXI, se intenta establecer cómo en una etapa de significativas transformaciones en Bolivia y en Argentina, Renacer sirve de herramienta para (y es expresión de) la disputa de sentidos dentro del grupo migrante y la legitimación de su(s) posicionamiento(s) político(s) en la esfera pública.The present work analyzes the construction of Renacer, a significant graphic communication production of the socalled “Bolivian community in Argentina”. This newspaper, which has reached its twelfth year of existence and uninterrupted circulationin the City of Buenos Aires, goes beyond the traditional newspaper format to inscribe itself within a matrix of construction of the identity of Bolivian migrants in Argentina. This matrix, far from expressing the Argentine hegemonic logic around regional immigration in general and Bolivian migrants in particular (homogeneity, passivity, docility, foreignness, etc.), exposes the complexity of immigration and its identifications. Renacer also entails certain theoretical challenges for the Communication Sciences and Anthropology as it reveals the political intervention of a poliphony that has been denied, hidden or repressed throughout the history of Argentina. This polyphony expresses the community complexities and heterogeneities that dispel the homogeneity and essentiality attributed to the identity while forcing the approach from its inherent diversity, conflictivity and politics. By circumscribing the analysis to the first decade of the 21st century – a stage of significant transformations in Bolivia and Argentina – we attempt to establish how Renacer serves as tool for (and is the expression of) the dispute over meanings within the migrant group and for the legitimization of their political positioning in the public sphere.Fil: Halpern, Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires; ArgentinaFil: Beccaria, Luciano Martín. Universidad de Buenos Aires. Facultad de Ciencias Sociales. Carrera de Ciencias de la Comunicación; Argentin

Seven mutations of the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

Permanent neonatal diabetes mellitus (PNDM) is a rare disorder usually presenting within 6 months of birth. Although several genes have been linked to this disorder, in almost half the cases documented in Italy, the genetic cause remains unknown. Because the Akita mouse bearing a mutation in the Ins2 gene exhibits PNDM associated with pancreatic beta cell apoptosis, we sequenced the human insulin gene in PNDM subjects with unidentified mutations. We discovered 7 heterozygous mutations in 10 unrelated probands. In 8 of these patients, insulin secretion was detectable at diabetes onset, but rapidly declined over time. When these mutant proinsulins were expressed in HEK293 cells, we observed defects in insulin protein folding and secretion. In these experiments, expression of the mutant proinsulins was also associated with increased Grp78 protein expression and XBP1 mRNA splicing, 2 markers of endoplasmic reticulum stress, and with increased apoptosis. Similarly transfected INS-1E insulinoma cells had diminished viability compared with those expressing WT proinsulin. In conclusion, we find that mutations in the insulin gene that promote proinsulin misfolding may cause PNDM

Efficacy and safety of growth hormone treatment in children with short stature: the Italian cohort of the GeNeSIS clinical study

Purpose: We examined auxological changes in growth hormone (GH)-treated children in Italy using data from the Italian cohort of the multinational observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) of pediatric patients requiring GH treatment. Methods: We studied 711 children (median baseline age 9.6 years). Diagnosis associated with short stature was as determined by the investigator. Height standard deviation score (SDS) was evaluated yearly until final or near-final height (n = 78). Adverse events were assessed in all GH-treated patients. Results: The diagnosis resulting in GH treatment was GH deficiency (GHD) in 85.5 % of patients, followed by Turner syndrome (TS 6.6 %). Median starting GH dose was higher in patients with TS (0.30 mg/kg/week) than patients with GHD (0.23 mg/kg/week). Median (interquartile range) GH treatment duration was 2.6 (0.6\u20133.7) years. Mean (95 % confidence interval) final height SDS gain was 2.00 (1.27\u20132.73) for patients with organic GHD (n = 18) and 1.19 (0.97\u20131.40) for patients with idiopathic GHD (n = 41), but lower for patients with TS, 0.37 ( 120.03 to 0.77, n = 13). Final height SDS was > 122 for 94 % of organic GHD, 88 % of idiopathic GHD and 62 % of TS patients. Mean age at GH start was lower for organic GHD patients, and treatment duration was longer than for other groups, resulting in greater mean final height gain. GH-related adverse events occurred mainly in patients diagnosed with idiopathic GHD. Conclusions: Data from the Italian cohort of GeNeSIS showed auxological changes and safety of GH therapy consistent with results from international surveillance databases

Migración y ciudadanía comunicacional medios, protesta y construcción política de grupos migrantes latinoamericanos en Argentina.

Tesis de MaestríaEn la presente tesis se propone realizar un recorrido por las luchas de los grupos migrantes de países latinoamericanos en Argentina, a través de sus medios de comunicación y de las movilizaciones en el espacio público, durante las primeras dos décadas del siglo XXI. Este trayecto pretende explicar las demandas de estos colectivos en términos de ampliación de ciudadanía, particularmente en lo referido a la construcción de ciudadanía comunicacional. La crisis política, económica y social que estalló en diciembre de 2001 en Argentina y se replicó en los años subsiguientes en varios países de América latina fue el punto inicial para la constitución de un colectivo migrante latinoamericano en tanto movimiento social transnacional, heterogéneo y solidario. Asimismo, la concurrencia de estos grupos trascendió las nacionalidades e incorporó marcas identitarias étnicas y de clase de manera complementaria. Entre las demandas del colectivo comenzó a tener relevancia la información y la comunicación como necesidades para la consecución de otros derechos."Fil: Beccaria, Luciano Martín. Universidad Nacional de San Martín. Escuela de Humanidades; Buenos Aires, Argentina

Víctimas y victimarios: niñez y adolescencia en las noticias televisivas

Fil: Ariza, Lucía. Dirección de Análisis, Investigación y Monitoreo, Defensoría del Público de Servicios de Comunicación Audiovisual, Argentina.Fil: Beccaria, Luciano Martín. Dirección de Análisis, Investigación y Monitoreo, Defensoría del Público de Servicios de Comunicación Audiovisual, Argentina.Este artículo indaga en las formas de tematización de las noticias sobre niños, niñas, adolescentes y jóvenes (NNA/J) emitidas en la Ciudad de Buenos Aires. El diseño de la investigación fue de corte cuali-cuantitativo y tomó como eje analítico central el concepto de tópico . Los datos estadísticos muestran la preexistencia de una “matriz policializante” que estructura la tematización de las noticias sobre NNA/J: antes que una selección casual, los hechos noticiables son priorizados en función de su potencial articulación con el policial. Por su parte, el análisis cualitativo permite diferenciar distintas estrategias en la construcción discursiva de víctimas y victimarios en las noticias. Estas estrategias se observan a lo largo de tres tipos de delitos: contra la integridad física, contra la propiedad privada, y de género. Palabras clave: Noticieros de TV; niñez, adolescencia y juventud; criminalización; victimización. Abstract: This article examines the ways in which TV news about children, teenagers and young people (CTY) are reported in the City of Buenos Aires. The research had on a quali-quantitative design, and took as its main analytical tool the concept of topic ( tópico ). The statistical data shows the pre-existence of a ‘policializing matrix’ that structures how CTY news are reported: rather than a casual selection, the noticeable facts are prioritized due to their potential to become police news. On its part, the qualitative analysis allows to differentiate strategies in the discursive construction of victims and perpetrators. These strategies are observed along three types of crimes: against personal integrity, against private property, and gender-related crimes. Key words: TV news programs; childhood, adolescence, youth; criminalization; victimization

Patients with biallelic mutations in the chloride channel gene CLCNKB: long-term management and outcome

BACKGROUND: Little information on the management and long-term follow-up of patients with biallelic mutations in the chloride channel gene CLCNKB is available. METHODS: Long-term follow-up was evaluated from 5.0 to 24 years (median, 14 years) after diagnosis in 13 patients with homozygous (n = 10) or compound heterozygous (n = 3) mutations. RESULTS: Medical treatment at last follow-up control included supplementation with potassium in 12 patients and sodium in 2 patients and medical treatment with indomethacin in 9 patients. At the end of follow-up, body height was 2.0 standard deviation score or less in 6 patients; 2 of these patients had growth hormone deficiency. Body weight (<or=2.0 standard deviation score in 6 patients) significantly increased (P < 0.05) at the end of follow-up in comparison to values at diagnosis. Nonpostural persistent proteinuria was present in 6 patients, and 4 patients had a glomerular filtration rate less than 75 mL/min/1.73 m(2) (<1.25 mL/s). CONCLUSION: These data show that some patients with biallelic mutations in the chloride channel gene CLCNKB tend to present with pathological proteinuria and impaired kidney function after a median follow-up of 14 years, and growth retardation is common and sometimes related to growth hormone deficiency in these patients

Rewarding Policemen Increases Crime. Another Surprising Result from the Inspection Game

Inspection games are 2x2 games in which one playermust decide whether to inspect the other player, who in turnmust decide whether to infringe a norm or a regulation.Inspection games have a single, mixed strategy Nashequilibrium, which has counter-intuitive comparative staticsproperties. This result has been used by Tsebelis (1989) andHoller (1992) to show that the economic approach to lawenforcement is not likely to generate clear-cut predictions.In this paper I discuss a variant of the inspection game inwhich the inspector can act as a Stackelberg leader. I willalso show that this version of the inspection game hascounter-intuitive comparative statics properties. Inparticular, increasing inspector’s incentives to enforce thelaw increases the frequency of law infractions. Copyright Kluwer Academic Publishers 2004

Diagnostic features of thyroid nodules in pediatrics

OBJECTIVE: To investigate a cohort of pediatric patients with thyroid nodules, defining histotype frequency and differences between subjects with hyperthyroidism and euthyroidism and benign and malignant nodules. DESIGN: Retrospective cohort. SETTING: Consecutive cases from 9 Italian pediatric endocrinology centers for the last 10 years. Patients One hundred twenty pediatric patients with thyroid nodules. Intervention Doppler ultrasonography was performed in 71 subjects; scintiscan, in 56; fine-needle aspiration biopsy in 104; and 63 underwent surgery. MAIN OUTCOME MEASURES: The differences in clinical, laboratory, and ultrasonographic data between patients with hyperthyroidism and euthyroidism and malignant and benign nodules were evaluated. RESULTS: One hundred fourteen patients had euthyroidism and 6, hyperthyroidism. The latter had more compressive signs (P=.003), greater nodule diameter (P=.02), intranodular vascularization pattern (P=.01), and increased scintiscan uptake (P<.001). Fine-needle aspiration biopsy disclosed benign lesions in 77 cases, malignant lesions in 19, and "suspicious" lesions in 8. Histologic examination disclosed 1 Hurthle cell and 5 follicular adenomas in patients with hyperthyroidism, whereas in patients with euthyroidism, 33 hyperplasic nodules, 19 carcinomas (14 papillary, 3 follicular, and 2 medullary), 3 follicular and 1 Hurthle cell adenoma, and 1 teratoma were detected. Nine patients had enhanced scintiscan uptake. Among the patients with euthyroidism, malignancies more frequently had palpable lymph nodes (P<.001), compressive signs (P=.004), microcalcifications (P<.001), intranodular vascularization (P=.01), and lymph node alterations (P<.001). CONCLUSIONS: The diagnosis of pediatric thyroid nodules should be based on a stepwise evaluation that includes clinical, laboratory, and radiographic modalities. While laboratory assessments establish thyroid function, ultrasonographic imaging identifies clinically unapparent nodules and provides detailed nodule characterization for suspected malignant lesions. Scintiscan in patients with hyperthyroidism and fine-needle aspiration biopsy in patients with euthyroidism represent the next logical ste

Diagnostic Features of Thyroid Nodules in Pediatrics

Objective: To investigate a cohort of pediatric patients with thyroid nodules, defining histotype frequency and differences between subjects with hyperthyroidism and euthyroidism and benign and malignant nodules. Design: Retrospective cohort. Setting: Consecutive cases from 9 Italian pediatric endocrinology centers for the last 10 years. Patients: One hundred twenty pediatric patients with thyroid nodules. Intervention: Doppler ultrasonography was performed in 71 subjects; scintiscan, in 56; fine-needle aspiration biopsy in 104; and 63 underwent surgery. Main Outcome Measures: The differences in clinical, laboratory, and ultrasonographic data between patients with hyperthyroidism and euthyroidism and malignant and benign nodules were evaluated. Results: One hundred fourteen patients had euthyroidism and 6, hyperthyroidism. The latter had more compressive signs (P=.003), greater nodule diameter (P=.02), intranodular vascularization pattern (P=.01), and increased scintiscan uptake (P<.001). Fine-needle aspiration biopsy disclosed benign lesions in 77 cases, malignant lesions in 19, and "suspicious" lesions in 8. Histologic examination disclosed 1 Hurthle cell and 5 follicular adenomas in patients with hyperthyroidism, whereas in patients with euthyroidism, 33 hyperplasic nodules, 19 carcinomas (14 papillary, 3 follicular, and 2 medullary), 3 follicular and 1 Hurthle cell adenoma, and 1 teratoma were detected. Nine patients had enhanced scintiscan uptake. Among the patients with euthyroidism, malignancies more frequently had palpable lymph nodes (P<.001), compressive signs (P=.004), micro-calcifications (P<.001), intranodular vascularization (P=.01), and lymph node alterations (P<.001). Conclusions: The diagnosis of pediatric thyroid nodules should be based on a stepwise evaluation that includes clinical, laboratory, and radiographic modalities. While laboratory assessments establish thyroid function, ultrasonographic imaging identifies clinically unapparent nodules and provides detailed nodule characterization for suspected malignant lesions. Scintiscan in patients with hyperthyroidism and fine-needle aspiration biopsy in patients with euthyroidism represent the next logical step