Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case-control study

Objective To determine the independent associations of antihypertensive drugs with the risk of incident gout among people with hypertension

Idoneidad y validez de herramientas que fomentan el aprendizaje asociativo a partir de exámenes tipo test

Depto. de Salud Pública y Materno - InfantilFac. de MedicinaFALSEsubmitte

Identificación de problemas relacionados con el medicamento y estrategias de mejora en personas mayores

Depto. de Farmacología, Farmacognosia y BotánicaDepto. de Salud Pública y Materno - InfantilFac. de FarmaciaFac. de MedicinaUniversidad Complutense de Madrid. Proyectos ApSsubmitte

The Risk of SARS-CoV-2 Infection in Pregnant Women: An Observational Cohort Study Using the BIFAP Database

Background: It has been suggested that women experiencing during pregnancy several physiological and immunological changes that might increase the risk of any infection including the SARS-CoV-2. Objective: We aimed to quantify the risk of SARS-CoV-2 infection during pregnancy compared with women with no pregnancies. Methods: We used data from the BIFAP database and a published algorithm to identify all pregnancies during 2020. Pregnancies were matched (1:4) by age region, and length of pregnancy with a cohort of women of childbearing age. All women with SARS-CoV-2 infection before entering the study were discarded. We estimated incidence rates of SARS-CoV-2 with 95% confidence intervals (CIs) expressed by 1000 person-months as well as Kaplan–Meier figures overall and also stratified according to pregnancy period: during pregnancy, at puerperium (from end of pregnancy up to 42 days) and after pregnancy. (from 43 days after pregnancy up to end pf study period (i.e., June 2021). We conducted a Cox regression to assess risk factors for SARS-COV infection. The incidence rate of SARS-CoV-2 infection expressed by 1000 person-months were. Results: There was a total of 103,185 pregnancies and 412,740 matched women at childbearing, with a mean age of 32.3 years. The corresponding incidence rates of SARS-CoV-2 infection according to cohorts were: 2.44 cases per 1000 person-months (confidence interval (CI) 95%: 2.40–2.50) and 4.29 (95% CI: 4.15–4.43) for comparison cohort. The incidence rate ratio (IRR) of SARS-CoV-2 was 1.76 (95% CI: 1.69–1.83). When analyzing according to pregnancy period, the IRRs were 1.30 (95% CI: 11.20–1.41) during the puerperium and 1.19 (95% CI: 41.15–1.23) after pregnancy. In addition to pregnancy itself, other important risk factors were obesity (1.33 (95% CI: 1.23–1.44)) and diabetes (1.23 (95% CI: 11.00–1.50). Conclusion: Pregnant women are at increased risk of SARS-CoV-2 infection compared with women of childbearing age not pregnant. Nevertheless, there is a trend towards reverting during puerperium and after pregnancy

Incidence, treatment and recurrence of endometriosis in a UK-based population analysis using data from The Health Improvement Network and the Hospital Episode Statistics database

<p><b>Purpose:</b> This retrospective study used medical records from The Health Improvement Network (THIN) and Hospital Episode Statistics (HES) database to evaluate endometriosis (incidence, treatment and need for recurrent invasive procedures) in the general UK population.</p> <p><b>Materials and methods:</b> Women aged 12–54 years between January 2000 and December 2010, with a Read code for endometriosis, were identified in THIN. Cases were validated by manual review of free-text comments in medical records and responses to physician questionnaires. False-negative cases were identified among women with Read codes for hysterectomy or dysmenorrhea. Prescriptions of medical therapies for endometriosis were identified in THIN. Cases of single and recurrent invasive procedures were identified in women with medical records in both THIN and HES.</p> <p><b>Results:</b> Overall, 5087 women had a Read code for endometriosis, corresponding to an incidence of 1.02 (95% confidence interval [CI]: 0.99–1.05) per 1000 person-years. After case validation, the estimate was 1.46 (95% CI: 1.43–1.50) per 1000 person-years. Medical therapy was prescribed to 55.5% of women with endometriosis in the first year after diagnosis. In total, 48.3% of women received invasive treatment during the study period; approximately one-fifth of these women required further invasive treatment, mainly in the 3 years after the index procedure.</p> <p><b>Conclusions:</b> Using Read codes as the only method to identify women with endometriosis underestimates incidence. Over half of women with recorded endometriosis are prescribed medical therapy in the first year after diagnosis. Women with diagnosed endometriosis are at risk of requiring recurrent invasive procedures.</p

El Aprendizaje y Servicio como herramienta para laaplicación de los objetivos de Salud Pública en el colectivode personas mayores

Introduction: Elderly are making more use of health services and exhibit a high consumption of medicines. This is associated with a difficulty in treatment compliance and with a greater risk of adverse reactions. The aim of this project is to evaluate the knowledge and handling of medicines in a group of elderly community centers. &nbsp; Material and methods: This study is part of a Learning and Service Project (LSP) between the Complutense University of Madrid (UCM) and Coslada Town Council. The students designed and elaborated a survey of 32 items and interviewed the elderly volunteers (N=366) during the period of Nov-Dec (2019). After collecting the information, a descriptive analysis stratified by sex was carried out. &nbsp; Results: The average age of participants was 70.7 years, with a majority of women (70.2%). More than two thirds perceived their quality of life to be between very good and good, with this perception being slightly higher in women. Participants take an average of 3.4 medicines and 10% forgot medication intake. Even though most of them are independent and autonomous when it comes to taking their medication, 38% use a reminder method. &nbsp; Conclusion: The group of elderly people in Coslada stands out for its highly perceived quality of life and knowledge of their therapeutic management. The LSP is a unique opportunity to directly extrapolate the knowledge of Public Health to a reality and social need.Introducción: Las personas mayores recurren con más frecuencia a los servicios sanitarios.&nbsp; El elevado consumo de medicamentos dificulta el cumplimiento terapéutico en este colectivo asociándose a un mayor riesgo de reacciones adversas. El objetivo de este proyecto es evaluar el conocimiento y manejo de los medicamentos en un grupo de personas que acuden a los centros de mayores. Material y métodos: Este estudio se enmarca en un proyecto de Aprendizaje y Servicio (ApS) entre la Universidad Complutense de Madrid (UCM) y el Ayuntamiento de Coslada. Los estudiantes diseñaron y elaboraron una encuesta de 32 ítems y entrevistaron a las personas mayores voluntarias (N=366) durante el periodo de Nov-Dic (2019). Tras la recogida de la información, se llevó a cabo un análisis descriptivo estratificado por sexo. Resultados: La edad media de los encuestados fue de 70,7 años, siendo mayoritariamente mujeres (70,2%). Más de dos tercios, percibe su calidad de vida entre muy buena y buena, siendo esta percepción ligeramente superior en mujeres. Los encuestados toman una media de 3,4 medicamentos y un 10% afirmo olvidar alguna toma. Pese a que la mayoría una independencia y autonomía a la hora de consumir la medicación, un 38% recurre a un método recordatorio. Conclusión: El colectivo de personas mayores de Coslada destaca por su alta calidad de vida percibida y conocimiento del manejo terapéutico. El ApS es una oportunidad única de extrapolación directa de conocimientos de Salud Pública a una realidad y necesidad socia