Tips for research recruitment: The views of sexual minority youth

Researchers often experience difficulties recruiting hard-to-reach populations. This is especially so for studies involving those who have been historically stigmatized, such as individuals who challenge heteronormative expectations or people who experience mental ill health. The authors aimed to obtain the views of sexual minority adolescents (n=25) about what encouraged their participation in a research project. The authors used a general inductive approach to analyze interview data. Feedback consisted of 2 main overarching themes: tips and suggestions for future research and appreciate participants’ motivation to get involved in research. Strategies for how recruitment can be optimized for studies involving sexual minority young people are discussed

Spin motive forces and current fluctuations due to Brownian motion of domain walls

We compute the power spectrum of the noise in the current due to spin motive forces by a fluctuating domain wall. We find that the power spectrum of the noise in the current is colored, and depends on the Gilbert damping, the spin transfer torque parameter $\beta$, and the domain-wall pinning potential and magnetic anisotropy. We also determine the average current induced by the thermally-assisted motion of a domain wall that is driven by an external magnetic field. Our results suggest that measuring the power spectrum of the noise in the current in the presence of a domain wall may provide a new method for characterizing the current-to-domain-wall coupling in the system.Comment: Submitted to "Special issue: Caloritronics" in Solid State Communication

Spin-transfer mechanism for magnon-drag thermopower

We point out a relation between the dissipative spin-transfer-torque parameter $\beta$ and the contribution of magnon drag to the thermoelectric power in conducting ferromagnets. Using this result we estimate $\beta$ in iron at low temperatures, where magnon drag is believed to be the dominant contribution to the thermopower. Our results may be used to determine $\beta$ from magnon-drag-thermopower experiments, or, conversely, to infer the strength of magnon drag via experiments on spin transfer

Beyond the trial: A systematic review of real-world uptake and engagement with digital self-help interventions for depression, low mood, or anxiety

Background: Digital self-help interventions (including online or computerized programs and apps) for common mental health issues have been shown to be appealing, engaging, and efficacious in randomized controlled trials. They show potential for improving access to therapy and improving population mental health. However, their use in the real world, that is, as implemented (disseminated) outside of research settings, may differ from that reported in trials, and implementation data are seldom reported. Objective: We aimed to review peer-reviewed articles reporting user uptake and/or ongoing use, retention, or completion data (hereafter ‘usage data’ or, for brevity, ‘engagement’) from implemented pure self-help (unguided) digital interventions for depression, anxiety, or the enhancement of mood. Methods: We conducted a systematic search of the Scopus, Embase, MEDLINE, and PsychINFO databases for studies reporting user uptake and/or usage data from implemented digital self-help interventions for the treatment or prevention of depression or anxiety, or the enhancement of mood, from 2002 to 2017. Additionally, we screened the reference lists of included articles, citations of these articles, and the titles of articles published in Internet Interventions, Journal of Medical Internet Research (JMIR), and JMIR Mental Health since their inception. We extracted data indicating the number of registrations or downloads and usage of interventions. Results: After the removal of duplicates, 970 papers were identified, of which ten met the inclusion criteria. Hand-searching identified one additional article. The included articles reported on seven publically available interventions. There was little consistency in the measures reported. The number of registrants or downloads ranged widely, from eight to over 40,000 per month. From 21% to 88% of users engaged in at least minimal use (e.g. used the intervention at least once or completed one module or assessment), while 7–42% engaged in moderate use (completing between 40% and 60% of modular fixed-length programs or continuing to use apps after four weeks). Indications of completion or sustained use (completion of all modules or the last assessment or continuing to use apps after six weeks or more) varied from 0.5% to 28.6%. Conclusions: Available data suggest that uptake and engagement vary widely among the handful of implemented digital self-help apps and programs which have reported this, and that usage may vary from that reported in trials. Implementation data should be routinely gathered and reported to facilitate improved uptake and engagement, arguably among the major challenges in digital health

Current-driven and field-driven domain walls at nonzero temperature

We present a model for the dynamics of current- and field-driven domain-wall lines at nonzero temperature. We compute thermally-averaged drift velocities from the Fokker-Planck equation that describes the nonzero-temperature dynamics of the domain wall. As special limits of this general description, we describe rigid domain walls as well as vortex domain walls. In these limits, we determine also depinning times of the domain wall from an extrinsic pinning potential. We compare our theory with previous theoretical and experimental work

When genomic medicine reveals misattributed genetic relationships – the debate about disclosure revisited

This is the author accepted manuscript. The final version is available from Nature Publishing Group via the DOI in this record.Purpose: Accidental discovery of misattributed parentage is an age-old problem in clinical medicine, but the ability to detect it routinely has increased recently as a result of highthroughput DNA sequencing technologies coupled with family sequencing studies. Problems arise at the clinical-research boundary, where policies and consent forms guaranteeing nondisclosure may conflict with standard clinical care. Methods: To examine the challenges of managing misattributed parentage within hybrid translational research studies, we use a case study of a developmentally delayed child with a candidate variant found through a largescale trio genome sequencing study in which data from unrelated samples is routinely excluded. Results: We discuss whether genetic parentage should be explicitly confirmed during clinical validation, thus giving greater weight to the diagnosis according to ACMG variant interpretation guidelines, and what tensions this approach would create. Conclusion: We recommend that the possibility of finding and disclosing misattributed parentage should be addressed during the consent or pre-test counselling process, and that clinical relevance should determine whether or not to disclose results in the clinic. This proposition has implications for research governance, and implies that it may not always be possible to uphold nondisclosure commitments as investigations move from research to clinical care.The authors wish to thank the DDD study (HICF-1009-003) and PAGE project (HICF-R7- 396) for providing inspiration for this paper. MP and the Wellcome Centre for Ethics and Humanities are supported by a Wellcome Centre Grant (203132/Z/16/Z). AL is supported by a collaborative award from the Wellcome (208053/Z/17/Z)

Spin motive forces due to magnetic vortices and domain walls

We study spin motive forces, i.e, spin-dependent forces, and voltages induced by time-dependent magnetization textures, for moving magnetic vortices and domain walls. First, we consider the voltage generated by a one-dimensional field-driven domain wall. Next, we perform detailed calculations on field-driven vortex domain walls. We find that the results for the voltage as a function of magnetic field differ between the one-dimensional and vortex domain wall. For the experimentally relevant case of a vortex domain wall, the dependence of voltage on field around Walker breakdown depends qualitatively on the ratio of the so-called $\beta$-parameter to the Gilbert damping constant, and thus provides a way to determine this ratio experimentally. We also consider vortices on a magnetic disk in the presence of an AC magnetic field. In this case, the phase difference between field and voltage on the edge is determined by the $\beta$ parameter, providing another experimental method to determine this quantity.Comment: 8 pages, 9 figures, submitted to PR

Optimizing propagating spin wave spectroscopy

The frequency difference between two oppositely propagating spin waves can be used to probe several interesting magnetic properties, such as the Dzyaloshinkii-Moriya interaction (DMI). Propagating spin wave spectroscopy is a technique that is very sensitive to this frequency difference. Here we show several elements that are important to optimize devices for such a measurement. We demonstrate that for wide magnetic strips there is a need for de-embedding. Additionally, for these wide strips there is a large parasitic antenna-antenna coupling that obfuscates any spin wave transmission signal, which is remedied by moving to smaller strips. The conventional antenna design excites spin waves with two different wave vectors. As the magnetic layers become thinner, the resulting resonances move closer together and become very difficult to disentangle. In the last part we therefore propose and verify a new antenna design that excites spin waves with only one wave vector. We suggest to use this antenna design to measure the DMI in thin magnetic layers.Comment: 12 pages, 4 figure