Favorable outcome of total hip arthroplasty with insufficient bone coverage of the roof reinforcement ring: a case report

A 59-year-old male patient underwent a total hip arthroplasty for the treatment of end-stage dysplastic osteoarthritis. A roof reinforcement ring, a cemented polyethylene cup, and a cementless stem were used. Extensive superolateral portion of the ring was uncovered by host bone. Morsellized autogenous femoral-head graft was impacted to fill the space between superolateral border of the ring and superior part of the dysplastic acetabulum. At the follow-up after 4-years, the patient had no complaints and was very satisfied with the operation result. The hip radiograph revealed no signs of instability of the acetabular component, and no bone graft resorption. Despite the suboptimal implantation of the ring compromising, apparently, mechanical stability of the prosthesis, the outcome was favorable. This result can be supported by the fixation of the metal ring with screws, the adequate orientation of the prosthesis, the position of hip´s center of rotation, and bone graft incorporation

As representações sociais dos pecuaristas familiares do Alto Camaquã para a construção de uma estratégia de desenvolvimento sustentável.

Editores Alexandre Hoffmann, Luciano Gebler

Diagnóstico do uso de nascentes como fonte de abastecimento de água pela pecuária familiar no território do Alto Camaquã, RS.

Editores Alexandre Hoffmann, Luciano Gebler

Dismetrias dos membros inferiores após artroplastias totais primárias da anca: medidas preventivas

Apesar de ser reconhecida como uma das intervenções de maior sucesso em cirurgia reconstrutiva ortopédica, a artroplastia total primária da anca não está isenta de complicações. Desigualdades no comprimento dos membros inferiores até 1 cm são comuns e, de uma forma geral, bem toleradas. Todavia, dismetrias maiores podem estar associadas a dor e a lesões nervosas e serem, por isso, motivo de insatisfação do doente e de litigância. Embora não se possa eliminar, de todo, as dismetrias após uma artroplastia total da anca, estas podem ser minimizadas através de uma série de procedimentos antes e durante a intervenção cirúrgica. Neste sentido, são de realçar o valor da anamnese e do exame físico com determinação do comprimento real e aparente dos membros inferiores, a avaliação e planificação radiográficas, uma diversidade de provas e medições efetuadas durante a operação e a cirurgia assistida por computador. A planificação radiográfica pré-operatória integra uma das etapas mais importantes no processo da implantação de uma prótese total da anca, de sorte a restabelecer a biomecânica da anca e preservar ou restituir a isometria dos membros inferiores, sem comprometer a estabilidade da prótese

Severidade da queima das folhas e quantificação de fenóis solúveis totais e lagnina solúveil em cultivares de cenoura.

O objetivo deste trabalho foi avaliar a severidade da doença em cultivares tradicionais de cenoura (Brasília, BRS Planalto, Juliana, BRS Esplanada, Branca Lunar, Amarela Solar e Londrina) em campo, bem com quantificar as concentrações de fenóis solúveis totais e lignina solúvel nas folhas.Resumo 1265

Aqua­(4,4′-bipyridine-κN)bis­(1,4-dioxo-1,4-dihydronaphthalen-2-olato-κ2 O 1,O 2)zinc 4,4′-bipyridine mono­solvate dihydrate

The reaction of 2-hy­droxy-1,4-naphtho­quinone and 4,4′-bipyridine with zinc acetate produced the title compound, [Zn(C10H5O3)2(C10H8N2)(H2O)]·C10H8N2·2H2O. The bond lengths and angles around the metal atom indicate a deviation from octa­hedral geometry. The two naphtho­quinone ligands coordinate in a cis fashion, with the 4,4′-bipyridine ligand and the water mol­ecules completing the coordination sphere of the metal atom. The asymmetric unit contains also one free 4,4′-bipyridine mol­ecule and two uncoordinated water mol­ecules. These mol­ecules make contacts with the complex through O—H⋯N and O—H⋯O hydrogen bonds, creating a layer two-dimensional network parallel to (121)

Schistosoma mansoni rSm29 Antigen Induces a Regulatory Phenotype on Dendritic Cells and Lymphocytes From Patients With Cutaneous Leishmaniasis

The immune response induced by Schistosma mansoni antigens is able to prevent immune-mediated diseases. Conversely, the inflammatory response in cutaneous leishmaniasis (CL), although responsible for controlling the infection, is also associated with the pathogenesis of disease. The aim of this study was to evaluate the potential of the S. mansoni Sm29 antigen to change certain aspects of the profiles of monocyte derived dendritic cells (MoDCs) and lymphocytes from subjects with CL in vitro. Expression of surface molecules and intracellular cytokines in the MoDCs and lymphocytes as well as the proliferation of Leishmania braziliensis were evaluated by flow cytometry. Levels of cytokines were evaluated in culture supernatants by ELISA. It was observed that stimulation by rSm29 increased the frequency of expression of CD83, CD80, CD86, and IL-10R in MoDCs compared to non-stimulated cultures. Additionally rSm29 decreased the frequency CD4+ and CD8+ T cells expressing CD28 and increased the frequency of CD4+CD25hi and CD4+CTLA-4+ T lymphocytes. Addition of rSm29 to cultures increased IL-10 levels and decreased levels of IL-12p40 and IFN-γ, while not altering TNF levels compared to non-stimulated cultures. This study showed that rSm29 induced a regulatory profile in MoDCs and lymphocytes and thereby regulated the exaggerated inflammation observed in CL. Considering that there are few therapeutic options for leishmaniasis, the use of rSm29 may be an alternative to current treatment and may be an important strategy to reduce the healing time of lesions in patients with CL

Cross-Study Projections of Genomic Biomarkers: An Evaluation in Cancer Genomics

Human disease studies using DNA microarrays in both clinical/observational and experimental/controlled studies are having increasing impact on our understanding of the complexity of human diseases. A fundamental concept is the use of gene expression as a “common currency” that links the results of in vitro controlled experiments to in vivo observational human studies. Many studies – in cancer and other diseases – have shown promise in using in vitro cell manipulations to improve understanding of in vivo biology, but experiments often simply fail to reflect the enormous phenotypic variation seen in human diseases. We address this with a framework and methods to dissect, enhance and extend the in vivo utility of in vitro derived gene expression signatures. From an experimentally defined gene expression signature we use statistical factor analysis to generate multiple quantitative factors in human cancer gene expression data. These factors retain their relationship to the original, one-dimensional in vitro signature but better describe the diversity of in vivo biology. In a breast cancer analysis, we show that factors can reflect fundamentally different biological processes linked to molecular and clinical features of human cancers, and that in combination they can improve prediction of clinical outcomes

Diferenças entre os sexos no ciúme romântico: um estudo brasileiro

The literature about romantic jealousy shows two principal theories in relation to the differences between sexes: specific innate module and socio-cognitive theory. This study intended to compare men and women answers using a questionnaire in the format of forced choice and the same questionnaire in the format of continuous measurement. 378 students participated, divided into two groups that answered the questionnaire in different formats. The differences between sexes was only evidenced on group 1 and few differences were found comparing men and women beliefs about infidelity and romantic relationship, on both groups. We pointed out the need for more studies in this field.La teoría sobre celos románticos apunta a dos propuestas teóricas principales en relación con las diferencias entre los sexos: módulo innato específico y teoría sociocognitiva, cada una con su metodología de evaluación. Este estudio se propuso comparar respuestas de hombres y mujeres usando un cuestionario de selección forzada y el mismo cuestionario pero con medición continua. Participaron 378 estudiantes, divididos en dos grupos que respondieron el cuestionario en los diferentes formatos. Las diferencias entre los sexos solo se evidenciaron en el grupo 1 y se encontraron pocas diferencias al comparar creencias de hombres y mujeres respecto a la infidelidad y la relación romántica. Se identificó la necesidad de más estudios sobre el tema.A literatura sobre ciúme romântico aponta duas propostas teóricas principais em relação as diferenças entre os sexos: módulo inato específico e teoria sócio-cognitiva, cada uma com metodologia de avaliação. Este estudo pretendeu comparar respostas de homens e mulheres usando um questionário em formato de escolha forçada e, o mesmo questionário, na forma de mensuração contínua. Participaram 378 estudantes, divididos em dois grupos que responderam ao questionário nos diferentes formatos. As diferenças entre os sexos só foram evidentes no grupo 1 e pouca diferença foi encontrada comparando-se crenças de homens e mulheres quanto à infidelidade e à relação romântica, nos dois grupos. Evidencia-se a necessidade de mais estudos sobre o tema