Teacher knowledge and initial teacher education in the English learning and skills sector

Recent reforms of initial teacher education (ITE) in the learning and skills sector(LSS) in England are standards based and emphasise subject specialism. The reforms are underpinned by objectivist epistemological assumptions which are incompatible with socio-cultural theories of professional knowledge, and ignore the diverse teaching roles and contexts in the sector and wider systemic issues. A qualitative scoping study found that LSS in-service trainee teachers drew on three types of knowledge resources, or clusters of ‘rules’ for practice, in their teaching: these were related to their subject/vocational area, generic teaching and learning processes and specific learners and groups. Trainees generated knowledge resources through participation in their workplace, ITE course and other social contexts, and from embedded and encoded workplace knowledge. Trainees’ beliefs, values and prior experiences were both a knowledge resource and influenced their engagement with knowledge generation activities. It is argued that using a knowledge resources perspective, which recognises how trainees generate knowledge and seeks to bridge gaps in their access to knowledge resources, would be more effective in supporting trainees’ development than the current reforms

Beam-Based Alignment of the NuMI Target Station Components at FNAL

The Neutrinos at the Main Injector (NuMI) facility is a conventional horn-focused neutrino beam which produces muon neutrinos from a beam of mesons directed into a long evacuated decay volume. The relative alignment of the primary proton beam, target, and focusing horns affects the neutrino energy spectrum delivered to experiments. This paper describes a check of the alignment of these components using the proton beam.Comment: higher resolution figures available on Fermilab Preprint Server (see SPIRES entry), accepted for publication in Nucl. Instr. and Meth.

The distribution of transit durations for Kepler planet candidates and implications for their orbital eccentricities

‘In these times, during the rise in the popularity of institutional repositories, the Society does not forbid authors from depositing their work in such repositories. However, the AAS regards the deposit of scholarly work in such repositories to be a decision of the individual scholar, as long as the individual's actions respect the diligence of the journals and their reviewers.’ Original article can be found at : http://iopscience.iop.org/ Copyright American Astronomical SocietyDoppler planet searches have discovered that giant planets follow orbits with a wide range of orbital eccentricities, revolutionizing theories of planet formation. The discovery of hundreds of exoplanet candidates by NASA's Kepler mission enables astronomers to characterize the eccentricity distribution of small exoplanets. Measuring the eccentricity of individual planets is only practical in favorable cases that are amenable to complementary techniques (e.g., radial velocities, transit timing variations, occultation photometry). Yet even in the absence of individual eccentricities, it is possible to study the distribution of eccentricities based on the distribution of transit durations (relative to the maximum transit duration for a circular orbit). We analyze the transit duration distribution of Kepler planet candidates. We find that for host stars with T > 5100 K we cannot invert this to infer the eccentricity distribution at this time due to uncertainties and possible systematics in the host star densities. With this limitation in mind, we compare the observed transit duration distribution with models to rule out extreme distributions. If we assume a Rayleigh eccentricity distribution for Kepler planet candidates, then we find best fits with a mean eccentricity of 0.1-0.25 for host stars with T ≤ 5100 K. We compare the transit duration distribution for different subsets of Kepler planet candidates and discuss tentative trends with planetary radius and multiplicity. High-precision spectroscopic follow-up observations for a large sample of host stars will be required to confirm which trends are real and which are the results of systematic errors in stellar radii. Finally, we identify planet candidates that must be eccentric or have a significantly underestimated stellar radius.Peer reviewedFinal Accepted Versio

Abacavir-Reactive memory T Cells are present in drug naïve individuals

Background Fifty-five percent of individuals with HLA-B*57:01 exposed to the antiretroviral drug abacavir develop a hypersensitivity reaction (HSR) that has been attributed to naïve T-cell responses to neo-antigen generated by the drug. Immunologically confirmed abacavir HSR can manifest clinically in less than 48 hours following first exposure suggesting that, at least in some cases, abacavir HSR is due to re-stimulation of a pre-existing memory T-cell population rather than priming of a high frequency naïve T-cell population. Methods To determine whether a pre-existing abacavir reactive memory T-cell population contributes to early abacavir HSR symptoms, we studied the abacavir specific naïve or memory T-cell response using HLA-B*57:01 positive HSR patients or healthy controls using ELISpot assay, intra-cellular cytokine staining and tetramer labelling. Results Abacavir reactive CD8+ T-cell responses were detected in vitro in one hundred percent of abacavir unexposed HLA-B*57:01 positive healthy donors. Abacavir-specific CD8+ T cells from such donors can be expanded from sorted memory, and sorted naïve, CD8+ T cells without need for autologous CD4+ T cells. Conclusions We propose that these pre-existing abacavir-reactive memory CD8+ T-cell responses must have been primed by earlier exposure to another foreign antigen and that these T cells cross-react with an abacavir-HLA-B*57:01-endogenous peptide ligand complex, in keeping with the model of heterologous immunity proposed in transplant rejection

Rationale and protocol for the 7- And 8-year longitudinal assessments of eye health in a cohort of young adults in the Raine Study

Introduction Eye diseases and visual impairment more commonly affect elderly adults, thus, the majority of ophthalmic cohort studies have focused on older adults. Cohort studies on the ocular health of younger adults, on the other hand, have been few. The Raine Study is a longitudinal study that has been following a cohort since their birth in 1989-1991. As part of the 20-year follow-up of the Raine Study, participants underwent a comprehensive eye examination. As part of the 27- and 28-year follow-ups, eye assessments are being conducted and the data collected will be compared with those of the 20-year follow-up. This will provide an estimate of population incidence and updated prevalence of ocular conditions such as myopia and keratoconus, as well as longitudinal change in ocular parameters in young Australian adults. Additionally, the data will allow exploration of the environmental, health and genetic factors underlying inter-subject differential long-term ocular changes. Methods and analysis Participants are being contacted via telephone, email and/or social media and invited to participate in the eye examination. At the 27-year follow-up, participants completed a follow-up eye screening, which assessed visual acuity, autorefraction, ocular biometry and ocular sun exposure. Currently, at the 28-year follow-up, a comprehensive eye examination is being conducted which, in addition to all the eye tests performed at the 27-year follow-up visit, includes tonometry, optical coherence tomography, funduscopy and anterior segment topography, among others. Outcome measures include the incidence of refractive error and pterygium, an updated prevalence of these conditions, and the 8-year change in ocular parameters. Ethics and dissemination The Raine Study is registered in the Australian New Zealand Clinical Trials Registry. The Gen2 20-year, 27-year and 28-year follow-ups are approved by the Human Research Ethics Committee of the University of Western Australia. Findings resulting from the study will be published in health or medical journals and presented at conferences. Trial registration number ACTRN12617001599369; Active, not recruiting

Produção imobiliária residencial, Florianópolis 1980-2010

A produção habitacional formal, por suas características e especificidades, ocupa um papel destacado na organização do espaço urbano e projeta sobre ele as relações capitalistas. Se o metabolismo socioeconômico mais geral se altera, também se altera o modo de produção do espaço urbano e da moradia. Esta pesquisa tem por objetivo compreender as principais transformações dos produtos imobiliários residenciais no Distrito Sede de Florianópolis, a partir do estudo de três tipologias: loteamentos, condomínios horizontais e condomínios verticais, no período compreendido entre 1981 e 2010. A partir da produção imobiliária residencial, procurou entender como as transformações mais gerais do sistema socioeconômico modificam - mas também se adaptam - ao tocarem territórios concretos, repletos de história, de conflitos e de interesses não necessariamente alinhados entre si. A pesquisa parte da hipótese de que nas últimas décadas os produtos imobiliários residenciais sofreram transformações importantes, em parte como respostas às mudanças no metabolismo do capitalismo em sua versão neoliberal e financeirizada; em parte condicionada por aspectos específicos de Florianópolis: seu território, seus agentes, suas instituições, seus conflitos e relações de poder.Programa de Educação Tutorial - PET. FNDE/MDE

Effect of deformation schedule on the microstructure and mechanical properties of a thermomechanically processed C-Mn-Si transformation-induced plasticity steel

Thermomechanical processing simulations were performed using a hot-torsion machine, in order to develop a comprehensive understanding of the effect of severe deformation in the recrystallized and nonrecrystallized austenite regions on the microstructural evolution and mechanical properties of the 0.2 wt pct C-1.55 wt pct Mn-1.5 wt pct Si transformation-induced plasticity (TRIP) steel. The deformation schedule affected all constituents (polygonal ferrite, bainite in different morphologies, retained austenite, and martensite) of the multiphased TRIP steel microstructure. The complex relationships between the volume fraction of the retained austenite, the morphology and distribution of all phases present in the microstructure, and the mechanical properties of TRIP steel were revealed. The bainite morphology had a more pronounced effect on the mechanical behavior than the refinement of the microstructure. The improvement of the mechanical properties of TRIP steel was achieved by variation of the volume fraction of the retained austenite rather than the overall refinement of the microstructure. <br /

Star Formation and Dynamics in the Galactic Centre

The centre of our Galaxy is one of the most studied and yet enigmatic places in the Universe. At a distance of about 8 kpc from our Sun, the Galactic centre (GC) is the ideal environment to study the extreme processes that take place in the vicinity of a supermassive black hole (SMBH). Despite the hostile environment, several tens of early-type stars populate the central parsec of our Galaxy. A fraction of them lie in a thin ring with mild eccentricity and inner radius ~0.04 pc, while the S-stars, i.e. the ~30 stars closest to the SMBH (<0.04 pc), have randomly oriented and highly eccentric orbits. The formation of such early-type stars has been a puzzle for a long time: molecular clouds should be tidally disrupted by the SMBH before they can fragment into stars. We review the main scenarios proposed to explain the formation and the dynamical evolution of the early-type stars in the GC. In particular, we discuss the most popular in situ scenarios (accretion disc fragmentation and molecular cloud disruption) and migration scenarios (star cluster inspiral and Hills mechanism). We focus on the most pressing challenges that must be faced to shed light on the process of star formation in the vicinity of a SMBH.Comment: 68 pages, 35 figures; invited review chapter, to be published in expanded form in Haardt, F., Gorini, V., Moschella, U. and Treves, A., 'Astrophysical Black Holes'. Lecture Notes in Physics. Springer 201