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Assessment of sexual difficulties associated with multi-modal treatment for cervical or endometrial cancer: A systematic review of measurement instruments
Background: Practitioners and researchers require an outcome measure that accurately identifies the range of common treatment-induced changes in sexual function and well-being experienced by women after cervical or endometrial cancer. This systematic review critically appraised the measurement properties and clinical utility of instruments validated for the measurement of female sexual dysfunction (FSD) in this clinical population.
Methods: A bibliographic database search for questionnaire development or validation papers was completed and methodological quality and measurement properties of selected studies rated using the Consensus-based Standards for the selection of health Measurement Instrument (COSMIN) checklist.
Results: 738 articles were screened, 13 articles retrieved for full text assessment and 7 studies excluded, resulting in evaluation of 6 papers; 2 QoL and 4 female sexual morbidity measures.
Five of the six instruments omitted one or more dimension of female sexual function and only one instrument explicitly measured distress associated with sexual changes as per DSM V (APA 2013) diagnostic criteria.
None of the papers reported measurement error, responsiveness data was available for only two instruments, three papers failed to report on criterion validity, and test-retest reliability reporting was inconsistent. Heterosexual penile-vaginal intercourse remains the dominant sexual activity focus for sexual morbidity PROMS terminology and instruments lack explicit reference to solo or non-coital sexual expression or validation in a non-heterosexual sample. Four out of six instruments included mediating treatment or illness items such as vaginal changes, menopause or altered body image.
Conclusions: Findings suggest that the Female Sexual Function Index (FSFI) remains the most robust sexual morbidity outcome measure, for research or clinical use, in sexually active women treated for cervical or endometrial cancer
High-fidelity readout of trapped-ion qubits
We demonstrate single-shot qubit readout with fidelity sufficient for
fault-tolerant quantum computation, for two types of qubit stored in single
trapped calcium ions. For an optical qubit stored in the (4S_1/2, 3D_5/2)
levels of 40Ca+ we achieve 99.991(1)% average readout fidelity in one million
trials, using time-resolved photon counting. An adaptive measurement technique
allows 99.99% fidelity to be reached in 145us average detection time. For a
hyperfine qubit stored in the long-lived 4S_1/2 (F=3, F=4) sub-levels of 43Ca+
we propose and implement a simple and robust optical pumping scheme to transfer
the hyperfine qubit to the optical qubit, capable of a theoretical fidelity
99.95% in 10us. Experimentally we achieve 99.77(3)% net readout fidelity,
inferring at least 99.87(4)% fidelity for the transfer operation.Comment: 4 pages, 3 figures; improved readout fidelity (numerical results
changed
Emergence of long-range order in BaTiO3 from local symmetry-breaking distortions
By using a symmetry motivated basis to evaluate local distortions against
pair distribution function data (PDF), we show without prior bias, that the
off-centre Ti displacements in the archetypal ferroelectric BaTiO3 are zone
centred and rhombohedral-like in nature across its known ferroelectric and
paraelectric phases. With our newly-gained insight we construct a simple Monte
Carlo (MC) model which captures our main experimental findings and demonstrate
how the rich crystallographic phase diagram of BaTiO3 emerges from correlations
of local symmetry-breaking distortions alone. Our results strongly support the
order-disorder picture for these phase transitions, but can also be reconciled
with the soft-mode theory of BaTiO3 that is supported by some spectroscopic
techniques.Comment: 5 pages, 3 figure
Scalable simultaneous multi-qubit readout with 99.99% single-shot fidelity
We describe single-shot readout of a trapped-ion multi-qubit register using
space and time-resolved camera detection. For a single qubit we measure
0.9(3)x10^{-4} readout error in 400us exposure time, limited by the qubit's
decay lifetime. For a four-qubit register (a "qunybble") we measure an
additional error of only 0.1(1)x10^{-4} per qubit, despite the presence of 4%
optical cross-talk between neighbouring qubits. A study of the cross-talk
indicates that the method would scale with negligible loss of fidelity to
~10000 qubits at a density <~1 qubit/um^2, with a readout time ~1us/qubit.Comment: 4 pages, 3 figures; simulations added to fig.3, with some further
text and figure revisions. Main results unchanged
Mentoring to reduce antisocial behaviour in childhood
The effects of social interventions need to be examined in real life situations as well as studie
Experimental recovery of a qubit from partial collapse
We describe and implement a method to restore the state of a single qubit, in
principle perfectly, after it has partially collapsed. The method resembles the
classical Hahn spin-echo, but works on a wider class of relaxation processes,
in which the quantum state partially leaves the computational Hilbert space. It
is not guaranteed to work every time, but successful outcomes are heralded. We
demonstrate using a single trapped ion better performance from this recovery
method than can be obtained employing projection and post-selection alone. The
demonstration features a novel qubit implementation that permits both partial
collapse and coherent manipulations with high fidelity.Comment: 5 pages, 3 figure
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